Nano-encapsulation of saffron extract through double-layered multiple emulsions of pectin and whey protein concentrate

Esfanjani, Afshin Faridi; Jafari, Seid Mahdi; Assadpoor, Elham; Mohammadi, Adeleh

doi:10.1016/j.jfoodeng.2015.06.022

Cited by 227 publications

(61 citation statements)

References 24 publications

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“…Another study by Esfanjani et al 2015 reports; encapsulation of saffron extract nanoparticles (<100 nm) via spray-drying. Solid lipid nanoparticles with carrier and sunscreen properties for topical delivery were prepared for encapsulated safranal formulations (Khameneh et al 2015).…”

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confidence: 99%

RETRACTED ARTICLE: The effect of safranal loaded mucoadhesive nanoemulsion on oxidative stress markers in cerebral ischemia

Ahmad

Naqvi

Ashafaq

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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Antioxidants, with reported neuroprotective activity, encounter free radical induced neural damage leading to reduced risk of cerebral ischemia-reperfusion (IR) injury. Safranal, an antioxidant drug with potential role in the amelioration of cerebral ischemia, endures low solubility and poor absorption property thus resulting a low serum and tissue bioavailability. This research aims to prepare nanoemulsion with the concept; to increase the bioavailability in order to reduce oxidative stress-induced brain injury as well as to evaluate the brain-drug targeting following non-invasive nasal route administration in middle cerebral artery occlusion (MCAO) animal model. Titration method was used to prepare safranal mucoadhesive nanoemulsion (SMNE) followed by further characterization, i.e. entrapment efficiency, particles size, and zeta potential study. Optimized SMNE showed; mean globule size of 89.64 nm (±9.12), zeta potential -11.39 mV (±1.32), drug content 98.47% (±1.01), and viscosity of 124 cp (±14). Rats were subjected to 2 h of MCAO, successively followed by a 22 h reperfusion, after which the grip strength, locomotor activity, and biochemical studies, i.e. glutathione reductase (GR), glutathione peroxidase, lipid peroxidation, catalase, and superoxide dismutase were studied as assessment tool for effective treatment in brain. SMNE administered i.n. (intranasal) in MCAO induced cerebral ischemia rats exhibited significant improvement in neurobehavioral (locomotor and grip strength) and antioxidant activity as well as histopathological studies. The toxicity studies performed at the end revealed safe nature of developed SMNE.

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confidence: 99%

RETRACTED ARTICLE: The effect of safranal loaded mucoadhesive nanoemulsion on oxidative stress markers in cerebral ischemia

Ahmad

Naqvi

Ashafaq

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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“…A thin pellet of each sample was generated by compressing the mixture with about ~60‏ kPa for ‏10 minutes in a compression instrument. To detect the structural composition of films incorporated with WPI/NaCS/EO reinforcements, FTIR spectroscopy (Spectrum two; Perkin Elmer, Waltham, MA, USA) in the wavenumber range of ‏400–4000‏ cm –‏1 with a resolution of ‏0.5 cm –‏1 ‏ was used …”

Section: Methodsmentioning

confidence: 99%

“…To detect the structural composition of films incorporated with WPI/NaCS/EO reinforcements, FTIR spectroscopy (Spectrum two; Perkin Elmer, Waltham, MA, USA) in the wavenumber range of 4000-400 cm -1 with a resolution of 0.5 cm -1 was used. 16…”

Section: Ftir Analysismentioning

confidence: 99%

Impact of operating parameters and wall material components on the characteristics of microencapsulated Melissa officinalis essential oil

Sani

Alizadeh

Pirsa

et al. 2018

Flavour & Fragrance J

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To develop a novel usage for functional essential oils, the present study aimed to evaluate the influence of process parameters on the characteristics of Melissa officinalis essential oil microencapsulated through whey protein isolate (WPI) and sodium caseinate (NaCS). Melissa officinalis was encapsulated via whey proteins and NaCS with variable ratios (0–100), core/coating ratios (10–100%), and ultrasonication power (50–150). The impacts of these variables were examined via response surface methodology. The findings demonstrated that lower particle sizes were obtained at higher amounts of WPI with the lowest level of applied sonication power. Desirability function results indicate that the maximum quantity of WPI with an ultrasonication power of 50 W led to the lowest particle size, zeta potential, and turbidity. The application of microcapsules loaded with Melissa officinalis was found to be useful to preserve their bioactive compounds and induces flavour stability, enabling the use of microcapsules in food formulations.

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“…It is derived from the dried stigmas of flowers of Crocus sativus (Esfanjani et al 2015;Khazaei et al 2016). …”

Section: Introductionmentioning

confidence: 99%

Detection of Methyl Orange in Saffron and Other Edibles Using Direct Injection Micellar Liquid Chromatography

Ashok

Agrawal²,

Esteve‐Romero

et al. 2016

Food Anal. Methods

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A simple, sensitive, rapid and eco friendly micellar liquid chromatographic method was developed for the detection of banned color methyl orange in counterfeit saffron and prepared foodstuffs. Methyl orange (p-[[p-(dimethylamino) phenyl] azo] benzenesulfonic acid sodium salt) is a hazardous dye used in titration and is known to be used as common adulterant in counterfeit saffron and cooked foodstuffs like Jalebi (Indian sweet), mango shake, Namkeen (salted snacks), tomato ketchup and ice candy etc., due to its pleasant orange color. In the present work, methyl orange was detected in various food samples using direct injection micellar liquid chromatography without any pretreatment step. A C18 column with an optimum micellar mobile phase containing 0.05-M sodium dodecyl sulfate (SDS), 2 % pentanol buffered to pH 7 was used. Detection was carried out at 458 nm. The retention time was 3.7 min without showing any matrix effect. Linearity (r > 0.9999), intraday and interday precision RSD (%) was less than 1.00 in micellar media. Limit of detection and quantification was found to be 0.05 mg/kg and 0.10 mg/ kg, respectively. Robustness study was also included as a part of method validation. The developed method proved to be reliable and sensitive for determination of methyl orange in real food samples.

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Nano-encapsulation of saffron extract through double-layered multiple emulsions of pectin and whey protein concentrate

Cited by 227 publications

References 24 publications

RETRACTED ARTICLE: The effect of safranal loaded mucoadhesive nanoemulsion on oxidative stress markers in cerebral ischemia

RETRACTED ARTICLE: The effect of safranal loaded mucoadhesive nanoemulsion on oxidative stress markers in cerebral ischemia

Impact of operating parameters and wall material components on the characteristics of microencapsulated Melissa officinalis essential oil

Detection of Methyl Orange in Saffron and Other Edibles Using Direct Injection Micellar Liquid Chromatography

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