Nano-engineered delivery systems for cancer imaging and therapy: Recent advances, future direction and patent evaluation

Nabil, Ghazal; Bhise, Ketki; Sau, Samaresh; Atef, Mohamed; El-Banna, H. A.; Iyer, Arun K.

doi:10.1016/j.drudis.2018.08.009

Cited by 82 publications

(58 citation statements)

References 181 publications

(206 reference statements)

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“…Indeed, intratumoral distribution of nanoparticles is highly variable and it is affected by intrinsic factors, such as interstitial fluid pressure (IFP), blood flow, diffusion, and stroma thickness [3,32]. In addition, tumor microenvironment presents different physico-chemical characteristics compared to normal healthy cells, such as acidic pH, hypoxia, active efflux pumps, hyperthermia, altered redox potential, and overexpressed molecular biomarkers (e.g., oncogenic proteins) [2].…”

Section: Theranostic Nanosystems: From Single To Multimodalitymentioning

confidence: 99%

“…Hybrid nanotheranostic systems are multicomponent individual particles, made of organic and inorganic materials, capable of both diagnostic and therapeutic actions, such as for drug/gene delivery, laser-assisted therapy (e.g., photodynamic therapy (PDT) and photothermal therapy (PTT)), and/or imaging modalities (e.g., magnetic resonance imaging (MRI) and positron emission tomography (PET) [2]. The association of these individual agents to a nanocarrier system expanded and enhanced the available nanotheranostics tools, offering the possibility of integrating both tumor accumulation, drug release, and multiple imaging modalities for optimal treatment outcomes [3].…”

Section: Introductionmentioning

confidence: 99%

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Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems

et al. 2019

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Theranostics has emerged in recent years to provide an efficient and safer alternative in cancer management. This review presents an updated description of nanotheranostic formulations under development for skin cancer (including melanoma), head and neck, thyroid, breast, gynecologic, prostate, and colon cancers, brain-related cancer, and hepatocellular carcinoma. With this focus, we appraised the clinical advantages and drawbacks of metallic, polymeric, and lipid-based nanosystems, such as low invasiveness, low toxicity to the surrounding healthy tissues, high precision, deeper tissue penetration, and dosage adjustment in a real-time setting. Particularly recognizing the increased complexity and multimodality in this area, multifunctional hybrid nanoparticles, comprising different nanomaterials and functionalized with targeting moieties and/or anticancer drugs, present the best characteristics for theranostics. Several examples, focusing on their design, composition, imaging and treatment modalities, and in vitro and in vivo characterization, are detailed herein. Briefly, all studies followed a common trend in the design of these theranostics modalities, such as the use of materials and/or drugs that share both inherent imaging (e.g., contrast agents) and therapeutic properties (e.g., heating or production reactive oxygen species). This rationale allows one to apparently overcome the heterogeneity, complexity, and harsh conditions of tumor microenvironments, leading to the development of successful targeted therapies.

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Section: Theranostic Nanosystems: From Single To Multimodalitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems

et al. 2019

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“…Active targeting agents can selectively transport NPs into the tumor mass and they bind to molecules expressed on the cancer cell surface with high affinity leading to endocytosis mediated cell uptake 23. The surface‐functionalized nanocarrier using specific ligands complements the passive targeting approach to improve the efficiency of nanocarrier delivery and tumor localization 24.…”

Section: Active Targetingmentioning

confidence: 99%

Interactions Between Tumor Biology and Targeted Nanoplatforms for Imaging Applications

Azizi

Dianat‐Moghadam

Salehi

et al. 2020

Adv Funct Materials

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Although considerable efforts have been conducted to diagnose, improve, and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. Perhaps the best hope for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase the current understanding of tumor biology, and will allow nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models. Owing to their intrinsic physicochemical characteristics, nanostructures (NSs) are valuable tools that have received much attention in nanoimaging. Consequently, rationally designed NSs have been successfully employed in cancer imaging for targeting cancer-specific or cancer-associated molecules and pathways. This review categorizes imaging and targeting approaches according to cancer type, and also highlights some new safe approaches involving membranecoated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells in the hope of developing more precise targeting and multifunctional nanotechnology-based imaging probes in the future.

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“…Gold nanoparticles (AuNPs) have amazing chemical–physical features that make them appealing for biotechnology and medical applications [ 1 , 2 , 3 , 4 , 5 ]. The advanced state of their synthetic chemistry allows strict control on shape, dimension and surface functionalization using, among others, thiols or organic molecules as capping agents that could be chemically modified to link targeting biomolecules or/and drugs [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Direct Conjugation of Resveratrol on Hydrophilic Gold Nanoparticles: Structural and Cytotoxic Studies for Biomedical Applications

et al. 2020

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Strongly hydrophilic gold nanoparticles (AuNPs), functionalized with citrate and L-cysteine, were synthetized and used as Resveratrol (RSV) vehicle to improve its bioavailability. Two different conjugation procedures were investigated: the first by adding RSV during AuNPs synthesis (1) and the second by adding RSV after AuNPs synthesis (2). The two different conjugated systems, namely AuNPs@RSV1 and AuNPs@RSV2 respectively, showed good loading efficiency (η%): η1 = 80 ± 5% for AuNPs@RSV1 and η2 = 20 ± 3% for AuNPs@RSV2. Both conjugated systems were investigated by means of Dynamic Light Scattering (DLS), confirming hydrophilic behavior and nanodimension (<2RH> 1 = 45 ± 12 nm and <2RH> 2 = 170 ± 30 nm). Fourier Transform Infrared Spectroscopy (FT-IR), Synchrotron Radiation induced X-Ray Photoelectron Spectroscopy (SR-XPS) and Near Edge X-ray Absorption Fine Structure (NEXAFS) techniques were applied to deeply understand the hooking mode of RSV on AuNPs surface in the two differently conjugated systems. Moreover, the biocompatibility of AuNPs and AuNPs@RSV1 was evaluated in the concentration range 1.0–45.5 µg/mL by assessing their effect on breast cancer cell vitality. The obtained data confirmed that, at the concentration used, AuNPs do not induce cell death, whereas AuNPs@RSV1 maintains the same anticancer effects as the unconjugated RSV.

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Nano-engineered delivery systems for cancer imaging and therapy: Recent advances, future direction and patent evaluation

Cited by 82 publications

References 181 publications

Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems

Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems

Interactions Between Tumor Biology and Targeted Nanoplatforms for Imaging Applications

Direct Conjugation of Resveratrol on Hydrophilic Gold Nanoparticles: Structural and Cytotoxic Studies for Biomedical Applications

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