Nano-hydroxyapatite radiolabeled with radium dichloride [223Ra] RaCl2 for bone cancer targeted alpha therapy: In vitro assay and radiation effect on the nanostructure

Gemini-Piperni, Sara; Ricci-Júnior, Eduardo; İlem-Özdemir, Derya; Batista, Beatriz da Silva; Alencar, Luciana Magalhães Rebêlo; Rossi, Alexandre M.; Santos-Oliveira, Ralph

doi:10.1016/j.colsurfb.2023.113174

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…Yang et al [ 109 ] spearheaded an intriguing study where they employed Pluronic F127 to formulate nanomicelles. These were entrusted with the task of delivering [223Ra] RaCl 2 —radium dichloride, an alpha-emitting radiopharmaceutical renowned for its ability to selectively adhere to bone malignancies and metastases [ 110 , 111 , 112 ]. Clinical explorations have lauded radium dichloride for its efficacy.…”

Section: Resultsmentioning

confidence: 99%

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Luo,

Sun,

Tan

et al. 2023

Pharmaceutics

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Osteosarcoma, a predominant malignant bone tumor, poses significant challenges due to its high metastatic and recurrent nature. Although various therapeutic strategies are currently in use, they often inadequately target osteosarcoma metastasis. This review focuses on the potential of nanoscale drug delivery systems to bridge this clinical gap. It begins with an overview of the molecular mechanisms underlying metastatic osteosarcoma, highlighting the limitations of existing treatments. The review then transitions to an in-depth examination of nanoscale drug delivery technologies, emphasizing their potential to enhance drug bioavailability and reduce systemic toxicity. Central to this review is a discussion of recent advancements in utilizing nanotechnology for the potential intervention of metastatic osteosarcoma, with a critical analysis of several preclinical studies. This review aims to provide insights into the potential applications of nanotechnology in metastatic osteosarcoma therapy, setting the stage for future clinical breakthroughs and innovative cancer treatments.

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Section: Resultsmentioning

confidence: 99%

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Luo,

Sun,

Tan

et al. 2023

Pharmaceutics

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“…Obviously an increase in the incidence rates associated with renal cancer and leukemia had suggested that free 224 Ra might lead to severe side effects. Therefore, several strategies about conjugating 224 Ra with hydroxyapatite nanoparticles, gold nanoparticles, calcium carbonate microspheres, and polyoxopalladates, have been exploited to address the biotoxicity issues of 224 Ra radionuclide therapy. The philosophy of these cases is trying to utilize nanoencapsulation to mitigate the migration of decay daughters of 224 Ra into normal tissues .…”

Section: Introductionmentioning

confidence: 99%

Preparation of Medical ²²⁸Th-²²⁴Ra Radionuclide Generator Based on SiO₂@TiO₂ Microspheres

Qiu,

Wu,

Luo

et al. 2024

Langmuir

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224Ra (T 1/2 = 3.63 d), an α-emitting radionuclide, holds significant promise in cancer endoradiotherapy. Current 224Ra-related therapy is still scarce because of the lack of reliable radionuclide supply. The 228Th-224Ra radionuclide generator can undoubtedly introduce continuous and sustainable availability of 224Ra for advanced nuclear medicine. However, conventional metal oxides for such radionuclide generators manifest suboptimal adsorption capacities for the parent nuclide, primarily attributable to their limited surface area. In this work, core–shell SiO2@TiO2 microspheres were proposed to develop as column materials for the construction of a 228Th-224Ra generator. SiO2@TiO2 microspheres were well prepared and systematically characterized, which has also been demonstrated to have good adsorption capacity to 228Th and very weak binding affinity toward 224Ra via simulated chemical separation. Upon introducing 228Th-containing solution onto the SiO2@TiO2 functional column, a 228Th-224Ra generator with excellent retention of the parent radionuclide and ideal elution efficiency of daughter radionuclide was obtained. The prepared 228Th-224Ra generator can produce 224Ra with high purity and medical usability in good elution efficiency (98.72%) even over five cycles. To the best of our knowledge, this is the first time that the core–shell mesoporous materials have been applied in a radionuclide generator, which can offer valuable insights for materials chemistry, radiochemical separation, and biological medicine.

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Biodistribution study of 211Pb progeny released from intravenously applied 223Ra labelled TiO2 nanoparticles in a mouse model

Sakmár,

Kozempel,

Kučka

et al. 2024

Nuclear Medicine and Biology

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Nano-hydroxyapatite radiolabeled with radium dichloride [223Ra] RaCl2 for bone cancer targeted alpha therapy: In vitro assay and radiation effect on the nanostructure

Cited by 6 publications

References 24 publications

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Preparation of Medical ²²⁸Th-²²⁴Ra Radionuclide Generator Based on SiO₂@TiO₂ Microspheres

Biodistribution study of 211Pb progeny released from intravenously applied 223Ra labelled TiO2 nanoparticles in a mouse model

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Nano-hydroxyapatite radiolabeled with radium dichloride [223Ra] RaCl2 for bone cancer targeted alpha therapy: In vitro assay and radiation effect on the nanostructure

Cited by 6 publications

References 24 publications

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Preparation of Medical 228Th-224Ra Radionuclide Generator Based on SiO2@TiO2 Microspheres

Biodistribution study of 211Pb progeny released from intravenously applied 223Ra labelled TiO2 nanoparticles in a mouse model

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Preparation of Medical ²²⁸Th-²²⁴Ra Radionuclide Generator Based on SiO₂@TiO₂ Microspheres