Nano-interfacial decoration of Halloysite Nanotubes for the development of antimicrobial nanocomposites

Saadat, Saeida; Pandey, Gaurav; Tharmavaram, Maithri; Braganza, Vincent; Rawtani, Deepak

doi:10.1016/j.cis.2019.102063

Cited by 97 publications

(29 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The vibration band of HNT/Ag at 1400 cm À1 could indicate the interaction between Ag NPs with fHNT at Si-C deformation. However, an alteration in frequencies associated with the OH functional group of fHNT and a noticeable wave number at 3626 cm À1 (OH stretching), 910 cm À1 and 1034 cm À1 (C-OH bending) evidently indicates the interaction of OH groups with Ag NPs [40,41]. Additionally, fHNT shows peaks at 1110 cm À1 , 1020 cm À1 and after the attachment of AgNPs with fHNT these peaks merged and shows the combined peaks at 1034 cm À1 [27,40 and 41] (Figure 5).…”

Section: Ftir Analysis Of Hnt Fhnt Ag Nps and Hnt/agmentioning

confidence: 99%

Physicochemical and biological assessment of silver nanoparticles immobilized Halloysite nanotubes-based resin composite for dental applications

Barot

Rawtani

Kulkarni

2020

Heliyon

Self Cite

View full text Add to dashboard Cite

The purpose of this study was to investigate the effect of Silver nanoparticle immobilized Halloysite Nanotubes (HNT/Ag) fillers on physicochemical, mechanical, and biological properties of novel experimental dental resin composite in order to compare with the properties of corresponding composites containing conventional glass fillers. Methods: Dental resin (Bis-GMA/TEGDMA with ratio 70/30) composites were prepared by incorporation of varied mass fraction of HNT/Ag. Experimental composites were divided into six groups, one control group and five experimental groups containing mass fraction 1 to 10.0 wt. % of HNT/Ag. Mechanical properties of the dental composites were recorded. Degree of conversion and depth of cure of the dental resin composites were assessed. Antimicrobial properties were assessed using agar diffusion test and evaluation of cytotoxicity were performed on NIH-3T3 cell line. Results: The inclusion of mass fractions (1-5 wt. %) of the HNT/Ag in dental resins composites, significantly improved mechanical properties. While, addition of larger mass fractions (7.5 and 10 wt. %) of the HNT/Ag did not show further improvement in the mechanical properties of dental resins composites. Theses composites also demonstrated satisfactory depth of cure and degree of conversion. A significant antibacterial activity was observed on S. mutans. No significant cytotoxicity was found on NIH-3T3 cell lines. Conclusion: The incorporation of HNT/Ag in Bis-GMA/TEGDMA dental resins composites resulted in enhancement in mechanical as well as biological properties for dental applications. Clinical significance: HNT/Ag containing dental composite is proposed to be highly valuable in the development of restorative dental material for patients with high risk of dental caries.

show abstract

Section: Ftir Analysis Of Hnt Fhnt Ag Nps and Hnt/agmentioning

confidence: 99%

Physicochemical and biological assessment of silver nanoparticles immobilized Halloysite nanotubes-based resin composite for dental applications

Barot

Rawtani

Kulkarni

2020

Heliyon

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, HNTs were loaded with antioxidant species to preserve food by designing packaging nanomaterials [56] and, finally, clay nanotubes were used for cultural heritage treatment by loading anti-acid species [57]. Recent reviews and research articles evidenced that halloysite is a support for the development of antimicrobial nanocomposites [58][59][60][61][62]. The control of the loading mechanism is crucial to extend the HNTs applications as drug delivery systems and nanocontainers [63].…”

Section: Introductionmentioning

confidence: 99%

Halloysite nanotubes filled with salicylic acid and sodium diclofenac: effects of vacuum pumping on loading and release properties

2021

View full text Add to dashboard Cite

In this work, we investigated the effects of the vacuum pumping on both the loading efficiencies and the release kinetics of halloysite nanotubes filled with drug molecules dissolved in ethanol. As model drugs, salicylic acid and sodium diclofenac were selected. For comparison, the loading of the drug molecules was conducted on platy kaolinite to explore the key role of the hollow tubular morphology on the filling mechanism of halloysite. The effects of the pressure conditions used in the loading protocol were interpreted and discussed on the basis of the thermodynamic results provided by Knudsen thermogravimetry, which demonstrated the ethanol confinement inside the halloysite cavity. Several techniques (TEM, FTIR spectroscopy, DLS and $$\zeta$$ ζ -potential experiments) were employed to characterize the drug filled nanoclays. Besides, release kinetics of the drugs were studied and interpreted according to the loading mechanism. This work represents a further step for the development of nanotubular carriers with tunable release feature based on the loading protocol and drug localization into the carrier. Graphic abstract The filling efficiency of halloysite nanotubes is enhanced by the reduction of the pressure conditions used in the loading protocol.

show abstract

“…Therefore, numerous papers are reporting the antimicrobial nanocomposites fabrication as wound dressing material. 27,30,52–59…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial dressing of silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites

et al. 2021

View full text Add to dashboard Cite

(Bio)nanocomposites have been studied for biomedical applications, including the treatment of wounds. However, wound infection is one of the main problems of wound care management, and the use of wound dressings with antibacterial agents is essential. This work focused on developing and characterizing silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites potentially suitable as antimicrobial dressing. Silver sulfadiazine was complexed inside the halloysite nanotubes lumen, and the drug-loaded nanotubes were incorporated in thermoplastic starch dispersion, forming the (bio)nanocomposites. The silver sulfadiazine-loaded halloysite and the (bio)nanocomposite were characterized by zeta potential, scanning electron microscopy, X-ray diffraction, and infrared spectroscopy. The dressing properties of (bio)nanocomposites (water vapor permeability and mechanical stability) and their antimicrobial efficacy by Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were also evaluated. Physicochemical studies suggested the silver sulfadiazine-loaded halloysite complexation (zeta potential of −38.9 mV) and its interactions with the starch forming the nanocomposites. The silver sulfadiazine-loaded halloysite/starch-based (bio)nanocomposites possessed a homogeneous and organized structure. Also, they had mechanical properties to be used as a dressing (13.73 ± 3.09 MPa and 3.17 ± 1.28% of elongation at break), and its permeability (6.18 ± 0.43 (10−13) g.Pa−1.s−1.m−1) could be able to maintain the environmental moisture at the wound surface. Besides that, the (bio)nanocomposites acted against the studied bacteria, being a potential contact antimicrobial and biodegradable wound dressing. Finally, the developed (bio)nanocomposites are semi-occlusive and good candidates for dry wounds to be widely in vitro and in vivo tested as controlled silver sulfadiazine delivery dressing.

show abstract

Nano-interfacial decoration of Halloysite Nanotubes for the development of antimicrobial nanocomposites

Cited by 97 publications

References 74 publications

Physicochemical and biological assessment of silver nanoparticles immobilized Halloysite nanotubes-based resin composite for dental applications

Physicochemical and biological assessment of silver nanoparticles immobilized Halloysite nanotubes-based resin composite for dental applications

Halloysite nanotubes filled with salicylic acid and sodium diclofenac: effects of vacuum pumping on loading and release properties

Antimicrobial dressing of silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites

Contact Info

Product

Resources

About