Nano-porous anodic alumina: fundamentals and applications in tissue engineering

Davoodi, Elham; Zhianmanesh, Masoud; Montazerian, Hossein; Milani, Abbas S.

doi:10.1007/s10856-020-06398-2

Cited by 40 publications

(20 citation statements)

References 180 publications

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“…PNMs are nanomaterials with a porous structure and high surface ratio, which are widely used in the fields of biomedical engineering [14][15][16][17][18] such as bone regeneration [18][19][20][21], drug delivery [22][23][24], cell trace, and regulation of cell differentiation. Since 2014, it has been reported that mesoporous bioactive glass nanomaterials can promote osteogenic differentiation through activation of autophagy [25].…”

Section: Introductionmentioning

confidence: 99%

Porous Nanomaterials Targeting Autophagy in Bone Regeneration

Zhang

Xiao

2021

Pharmaceutics

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Porous nanomaterials (PNMs) are nanosized materials with specially designed porous structures that have been widely used in the bone tissue engineering field due to the fact of their excellent physical and chemical properties such as high porosity, high specific surface area, and ideal biodegradability. Currently, PNMs are mainly used in the following four aspects: (1) as an excellent cargo to deliver bone regenerative growth factors/drugs; (2) as a fluorescent material to trace cell differentiation and bone formation; (3) as a raw material to synthesize or modify tissue engineering scaffolds; (4) as a bio-active substance to regulate cell behavior. Recent advances in the interaction between nanomaterials and cells have revealed that autophagy, a cellular survival mechanism that regulates intracellular activity by degrading/recycling intracellular metabolites, providing energy/nutrients, clearing protein aggregates, destroying organelles, and destroying intracellular pathogens, is associated with the phagocytosis and clearance of nanomaterials as well as material-induced cell differentiation and stress. Autophagy regulates bone remodeling balance via directly participating in the differentiation of osteoclasts and osteoblasts. Moreover, autophagy can regulate bone regeneration by modulating immune cell response, thereby modulating the osteogenic microenvironment. Therefore, autophagy may serve as an effective target for nanomaterials to facilitate the bone regeneration process. Increasingly, studies have shown that PNMs can modulate autophagy to regulate bone regeneration in recent years. This paper summarizes the current advances on the main application of PNMs in bone regeneration, the critical role of autophagy in bone regeneration, and the mechanism of PNMs regulating bone regeneration by targeting autophagy.

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Section: Introductionmentioning

confidence: 99%

Porous Nanomaterials Targeting Autophagy in Bone Regeneration

Zhang

Xiao

2021

Pharmaceutics

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“…Mesoporous nanostructures are attractive building blocks primarily for their biomolecule adsorption/desorption capabilities. 76 Mesoporous silica has been incorporated into hybrid nanosystems as MSNs or coatings. MSNs introduced in 1968 were noticed for their high surface area and tunable pore size.…”

Section: Inorganic Building Blocksmentioning

confidence: 99%

Hybrid Nanosystems for Biomedical Applications

et al. 2021

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Inorganic/organic hybrid nanosystems have been increasingly developed for their versatility and efficacy at overcoming obstacles not readily surmounted by nonhybridized counterparts. Currently, hybrid nanosystems are implemented for gene therapy, drug delivery, and phototherapy in addition to tissue regeneration, vaccines, antibacterials, biomolecule detection, imaging probes, and theranostics. Though diverse, these nanosystems can be classified according to foundational inorganic/organic components, accessory moieties, and architecture of hybridization. Within this Review, we begin by providing a historical context for the development of biomedical hybrid nanosystems before describing the properties, synthesis, and characterization of their component building blocks. Afterward, we introduce the architectures of hybridization and highlight recent biomedical nanosystem developments by area of application, emphasizing hybrids of distinctive utility and innovation. Finally, we draw attention to ongoing clinical trials before recapping our discussion of hybrid nanosystems and providing a perspective on the future of the field.

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“…Anodizing belongs to electrochemical technology, which has been widely used in sewage treatment, battery energy, and bionanotechnology ( Mandal et al, 2017 ; Davoodi et al, 2020 ; Janaina and Santos, 2021 ). In recent years, anodizing has been extensively used in implant surface for modifications owing to its simplicity, economy, and universality ( Tang et al, 2016 ).…”

Section: Surface Modification Technologymentioning

confidence: 99%

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

Sheng

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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With the development of three-dimensional (3D) printed technology, 3D printed alloy implants, especially titanium alloy, play a critical role in biomedical fields such as orthopedics and dentistry. However, untreated titanium alloy implants always possess a bioinert surface that prevents the interface osseointegration, which is necessary to perform surface modification to enhance its biological functions. In this article, we discuss the principles and processes of chemical, physical, and biological surface modification technologies on 3D printed titanium alloy implants in detail. Furthermore, the challenges on antibacterial, osteogenesis, and mechanical properties of 3D-printed titanium alloy implants by surface modification are summarized. Future research studies, including the combination of multiple modification technologies or the coordination of the structure and composition of the composite coating are also present. This review provides leading-edge functionalization strategies of the 3D printed titanium alloy implants.

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Nano-porous anodic alumina: fundamentals and applications in tissue engineering

Cited by 40 publications

References 180 publications

Porous Nanomaterials Targeting Autophagy in Bone Regeneration

Porous Nanomaterials Targeting Autophagy in Bone Regeneration

Hybrid Nanosystems for Biomedical Applications

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

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