2011
DOI: 10.1021/nn200173u
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Nano Self-Assembly of Recombinant Human Gelatin Conjugated with α-Tocopheryl Succinate for Hsp90 Inhibitor, 17-AAG, Delivery

Abstract: A wide variety of drug delivery systems have been developed for the delivery of anticancer agents. One of the most frequently used natural biomaterials in drug delivery systems is polysaccharides; however, they are difficult to digest and to eliminate from the body after systemic administration due to their high molecular weight natures and the absence of degrading enzymes. Therefore, the development of degradable and eliminable natural biomaterials is critical for successful in vivo applications. In the prese… Show more

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Cited by 74 publications
(38 citation statements)
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“…The tumour volume in mice treated with free 17-AAG was increased 20 times relative to the initial volume, whereas that of 17-AAG/ rHG-TOS nanoparticles was elevated 15 times (Won et al 2011). After intraperitoneal injection of DOXloaded GA-cross-linked GNPs into rats, the efficiency of DOX was enhanced compared to free drugs; however, high cardiotoxicity was also observed upon repeated administration.…”
Section: Gelatin As Drug Delivery Vehiclesmentioning
confidence: 91%
See 1 more Smart Citation
“…The tumour volume in mice treated with free 17-AAG was increased 20 times relative to the initial volume, whereas that of 17-AAG/ rHG-TOS nanoparticles was elevated 15 times (Won et al 2011). After intraperitoneal injection of DOXloaded GA-cross-linked GNPs into rats, the efficiency of DOX was enhanced compared to free drugs; however, high cardiotoxicity was also observed upon repeated administration.…”
Section: Gelatin As Drug Delivery Vehiclesmentioning
confidence: 91%
“…Meanwhile, like other animal-origin proteins, gelatin is also questioned for its risk of carrying harmful agents such as transmissible spongiform encephalopathies (TSEs). However, in the case of gelatin, the rigorous manufacturing processes such as acid, alkaline and heat treatments should be sufficient effective to inactivate TSE (Won et al 2011). Additionally, recombinant human gelatin (rHG), which is commercially available, non-toxic and low immunogenic, can be an ideal substitute for the natural one (Won et al 2011).…”
Section: Drawbacks and Challengesmentioning
confidence: 99%
“…Alpha-tocopheryl succinate (a-TOS) is known as a kind of vitamin E derivative that can induce apoptosis of various types of cancer cells, inhibit cells cycle, and disrupt the necessary autocrine signaling pathways of tumor growth [41,42]. a-TOS, composed of three domains (the functional domain, the signaling domain, and the hydrophobic domain) [43e45] can kill cancer cells, while not affecting the proliferation of most normal cells [46,47].…”
Section: Introductionmentioning
confidence: 99%
“…3b). These results suggest that the renal route and glomerular filtration can gradually eliminate the MC gel (34).…”
Section: Bio-distribution Of Gel/micelle Combination Systemmentioning
confidence: 70%