Nano-silver in situ hybridized collagen scaffolds for regeneration of infected full-thickness burn skin

Song, Junfei; Zhang, Pengfei; Liu, Cheng; Liao, Yue; Xu, Bing; Bao, Rui; Wang, Wei; Liu, Wenguang

doi:10.1039/c5tb00205b

Cited by 66 publications

(38 citation statements)

References 45 publications

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“…The hybrid scaffold treated group showed rapid wound contraction from 12 th day onwards, which is also reflected in the digital images. The in-vivo study reveals that the prepared hybrid material possesses better wound closure efficiency on the 21 st day of healing when compared to the 3D-protein bilayer based dressing and collagen-nano silver scaffold for burn wound healing 43,44 . In our hybrid scaffold, the collagen acts as a substrate for the attachment, proliferation and differentiation of the cells and TiO 2 nanoparticles provides bacteria-free micro-environment during the wound healing.…”

Section: Resultsmentioning

confidence: 98%

A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation

Kalirajan

Hameed

Subbiah

et al. 2019

Sci Rep

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Creating hybrid materials with multifunctionality and robust mechanical stability from natural resources is a challenging proposition in materials science. Here, we report the scalable synthesis of hybrid collagen scaffolds using collagen extracted from leather industry wastes and sago starch derived from agro-industry. The hybrid scaffolds were incorporated with TiO2 nanoparticles and cross-linked with oxidized sago starch. The biocompatibility, thermal stability and antimicrobial property of hybrid scaffold enabled its application in burn wound healing demonstrated through albino rat models. The highly porous hybrid scaffolds are shown to be super-compressible, which is typically forbidden in materials of biological origin. We demonstrate that the hybrid scaffolds concurrently display both adsorption and absorption behavior in the removal of oil and dye molecules, respectively from contaminated water. This study paves the way for the development of novel multifunctional and shape recoverable hybrid materials specifically from renewable resources.

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Section: Resultsmentioning

confidence: 98%

A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation

Kalirajan

Hameed

Subbiah

et al. 2019

Sci Rep

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“…By combining both polymers of biological origin (‘biopolymers’) and bio‐active NPs, it is possible to obtain so‐called ‘bionanocomposites’, which have been reviewed in detail elsewhere . For example, both collagen and gelatin (denatured collagen) have been combined to Ag NPs, with the objective of exploiting gelatin intrinsic biological properties while also imparting antimicrobial activity (Fig. (A)).…”

Section: Biological Responsementioning

confidence: 99%

Soft nanocomposites: nanoparticles to tune gel properties

Silva

Dreiss

2015

Polymer International

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The demand for new, soft materials with bespoke physical and biological characteristics and functionality has fuelled the research into nanocomposite hydrogels. 'Soft' nanocomposites -nanoparticles within a hydrated, polymeric gel matrix -offer a simple, yet versatile, platform for the design of materials with specific -and tunable -properties. Indeed, the 'soft' properties of the matrix can be combined with the inherent functionality of the nanoparticles (drug loading, antimicrobial, light refraction etc.) or give rise to altogether new characteristics (toughness, optical properties, self-healing etc.) evolved from the synergistic interaction of the polymer chains with the particles. In this review, we report the evolution and achievements of nanocomposite gels, with a focus on mechanisms and structure. The review is therefore structured around the properties resulting from the gel/nanoparticle association, rather than a classification based on applications or specific types of polymer or nanoparticles. How can nanoparticles tune mechanical, optical, biological properties or impart stimuli-responsiveness to a polymer gel matrix − and how is this behaviour linked to the underlying structure?

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“…A variety of positive factors such as antimicrobial materials [ 10 – 12 ], growth factors [ 13 ], and physical stimulation (electrical stimulation) [ 14 ] were used to functionalize the implants to achieve better therapeutic effect. Among these beneficial factors, growth factor has positive biological activity on the proliferation, migration and differentiation of cells, and plays an important role in skin regeneration.…”

Section: Introductionmentioning

confidence: 99%

Polydopamine-assisted PDGF-BB immobilization on PLGA fibrous substrate enhances wound healing via regulating anti-inflammatory and cytokine secretion

et al. 2020

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Platelet-derived growth factor-bb (PDGF-BB) is a potent chemokine and mitogen for fibroblasts, keratinocytes, and vascular endothelium in the injured area, believed to be effective in wound healing. However, the short half-life of PDGF-BB and its rapid release from the wound surface limited its efficacy in vivo and vitro. To evaluate the wound healing effects of dorsal skin in SD rats with polydopamine-assisted immobilized PDGF-BB on PLGA nanofibrous substrate. First, the effects of pDA-coating and PDGF-BB immobilization on the morphology, compositions, and hydrophilicity of substrates were evaluated in details. Second, the wound healing effect of pDA/PLGA/PDGF-BB substrate was assessed in the dorsal skin of SD rats. Last, the cytokine analysis by ELISA method was employed to evaluate the advantages of pDA/PLGA/PDGF-BB substrate on anti-inflammatory, angiogenesis, and cellular proliferation. This method significantly improved the immobilization amount and stability of PDGF-BB on the substrate (p<0.01), further improved the hydrophilicity of substrates (p<0.05). Furthermore, the wound closure process was much more accelerated in the pDA/ PLGA/PDGF-BB group (p<0.05). H&E and CD31 staining informed that the wound treated by pDA/PLGA/PDGF-BB substrate showed a high degree of regeneration and angiogenesis. The cytokine analysis showed that pDA significantly reduced the high level of inflammatory cytokines such as TNF-α (p<0.05). And the immobilized PDGF-BB significantly elevated the level of TGF-β and VEGF (p<0.05). The pDA/PLGA/PDGF-BB substrate showed great therapeutic effect on wound healing compared with other control groups via regulating anti-inflammatory, angiogenesis, and cellular proliferation. Absolutely, this report offered an available novel method for skin regeneration.

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Nano-silver in situ hybridized collagen scaffolds for regeneration of infected full-thickness burn skin

Abstract: Histidine incorporated into a collagen matrix was used as a template to chelate silver ions which were reduced to silver nanoparticles in situ.

Cited by 66 publications

References 45 publications

A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation

A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation

Soft nanocomposites: nanoparticles to tune gel properties

Polydopamine-assisted PDGF-BB immobilization on PLGA fibrous substrate enhances wound healing via regulating anti-inflammatory and cytokine secretion

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