Nano-Size Characterization and Antifungal Evaluation of Essential Oil Molecules-Loaded Nanoliposomes

Aguilar-Pérez, Katya M.; Medina, Dora I.; Parra‐Saldívar, Roberto; Iqbal, Hafiz M.N.

doi:10.3390/molecules27175728

Cited by 8 publications

(7 citation statements)

References 51 publications

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“…The CEO-loaded nanoliposomes displayed a maximum entrapment efficacy of 91.57 2.5% in comparison to TTO-loaded nanoliposomes. The CEO-loaded nanoliposome fraction demonstrated the highest MGI when tested against T. rubrum strains …”

Section: Vesicular Drug Delivery Systemsmentioning

confidence: 99%

“…The CEO-loaded nanoliposome fraction demonstrated the highest MGI when tested against T. rubrum strains. 178 Niosomes. Niosomes are nonionic surfactants, a new vesicular delivery mechanism that is thermodynamically stable and can be used to deliver drugs on a continuous, controlled, and targeted basis.…”

Section: Disorders Using Topical Drug Deliverymentioning

confidence: 99%

“…The CEO-loaded nanoliposome fraction demonstrated the highest MGI when tested against T. rubrum strains. 178 …”

Section: Vesicular Drug Delivery Systemsmentioning

confidence: 99%

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New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

et al. 2023

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Skin, the largest organ in humans, is an efficient route for the delivery of drugs as it circumvents several disadvantages of the oral and parenteral routes. These advantages of skin have fascinated researchers in recent decades. Drug delivery via a topical route includes moving the drug from a topical product to a locally targeted region with dermal circulation throughout the body and deeper tissues. Still, due to the skin's barrier function, delivery through the skin can be difficult. Drug delivery to the skin using conventional formulations with micronized active components, for instance, lotions, gels, ointments, and creams, results in poor penetration. The use of nanoparticulate carriers is one of the promising strategies, as it provides efficient delivery of drugs through the skin and overcomes the disadvantage of traditional formulations. Nanoformulations with smaller particle sizes contribute to improved permeability of therapeutic agents, targeting, stability, and retention, making nanoformulations ideal for drug delivery through a topical route. Achieving sustained release and preserving a localized effect utilizing nanocarriers can result in the effective treatment of numerous infections or skin disorders. This article aims to evaluate and discuss the most recent developments of nanocarriers as therapeutic agent vehicles for skin conditions with patent technology and a market overview that will give future directions for research. As topical drug delivery systems have shown great preclinical results for skin problems, for future research directions, we anticipate including in-depth studies of nanocarrier behavior in various customized treatments to take into account the phenotypic variability of the disease.

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Section: Vesicular Drug Delivery Systemsmentioning

confidence: 99%

Section: Disorders Using Topical Drug Deliverymentioning

confidence: 99%

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New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

et al. 2023

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“…The size of liposomes ranges from 20 nm (nanoliposomes) to the micrometer scale with the phospholipid bilayer being 4–5 nm thick. Liposomes can encapsulate hydrophobic and hydrophilic drugs in their structure, being effective in drug delivery [ 91 , 92 , 93 ]. Aguilar-Pérez et al [ 93 ] formulated and characterized nanoliposomes comprising various TTO concentrations (1.2–6.2 mM) and tested the antifungal activity against Trichophyton rubrum through the mycelial growth inhibition test.…”

Section: Biological Properties Of Ttomentioning

confidence: 99%

Tea Tree Oil: Properties and the Therapeutic Approach to Acne—A Review

et al. 2023

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Acne vulgaris is an inflammatory dermatological pathology that affects mostly young people. However, it can also appear in adulthood, mainly in women. It has a high psychosocial impact, not only at the time of active lesions but also due to the consequences of lesions such as scarring and hyperpigmentation. Several factors are involved in the physiopathology of acne and the constant search for active ingredients is a reality, namely phytotherapeutic ingredients. Tea tree oil is an essential oil extracted from Melaleuca alternifolia (Maiden & Betch) Cheel with known antibacterial, anti-inflammatory, and antioxidant properties, making it a candidate for the treatment of acne. This review aims to describe the various properties of tea tree oil that make it a possible ingredient to use in the treatment of acne and to present several human studies that have evaluated the efficacy and safety of using tea tree oil in the treatment of acne. It can be concluded that tea tree oil has good antibacterial, anti-inflammatory, and antioxidant properties that result in a decrease in the number of inflammatory lesions, mainly papules, and pustules. However, given the diversity of study designs, it is not possible to draw concrete conclusions on the efficacy and safety of this oil in the treatment of acne.

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“…Nanoliposomes are a form of drug delivery that are gaining popularity due to their safety, patient compliance, high interlocking efficiency, and rapid action. Several of the biological effects of natural essential oils, including fungal inhibition, are of great interest [ 159 ].…”

Section: Future Perspectives and Challenges Related To The Use Of Ant...mentioning

confidence: 99%

Specific Focus on Antifungal Peptides against Azole Resistant Aspergillus fumigatus: Current Status, Challenges, and Future Perspectives

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Velasco

et al. 2022

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The prevalence of fungal infections is increasing worldwide, especially that of aspergillosis, which previously only affected people with immunosuppression. Aspergillus fumigatus can cause allergic bronchopulmonary aspergillosis and endangers public health due to resistance to azole-type antimycotics such as fluconazole. Antifungal peptides are viable alternatives that combat infection by forming pores in membranes through electrostatic interactions with the phospholipids as well as cell death to peptides that inhibit protein synthesis and inhibit cell replication. Engineering antifungal peptides with nanotechnology can enhance the efficacy of these therapeutics at lower doses and reduce immune responses. This manuscript explains how antifungal peptides combat antifungal-resistant aspergillosis and also how rational peptide design with nanotechnology and artificial intelligence can engineer peptides to be a feasible antifungal alternative.

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Nano-Size Characterization and Antifungal Evaluation of Essential Oil Molecules-Loaded Nanoliposomes

Cited by 8 publications

References 51 publications

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

Tea Tree Oil: Properties and the Therapeutic Approach to Acne—A Review

Specific Focus on Antifungal Peptides against Azole Resistant Aspergillus fumigatus: Current Status, Challenges, and Future Perspectives

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