Nano-sized beads and porous fiber constructs of Poly(ε-caprolactone) produced by electrospinning

Hsu, Chen-Ming; Shivkumar, S.

doi:10.1023/b:jmsc.0000025826.36080.cf

Cited by 89 publications

(46 citation statements)

References 14 publications

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“…35À37 Because of the fact that the electrospinning solution at a high concentration level was highly viscoelastic, the primary jet and subsequently branched mini-jets underwent a long elongation flow and then splayed into thousands of mini-jets during the electrospinning process. 38 This prolonged the splitting and splaying region and induced the unstable and repeated splaying of the jets. The multiple splaying could form various mini jets during its transit to the collector and contributed to the formation of bimodal diameter distribution for the deposition fibers.…”

Section: Resultsmentioning

confidence: 99%

Electrospun Polyethylene Oxide/Cellulose Nanocrystal Composite Nanofibrous Mats with Homogeneous and Heterogeneous Microstructures

et al. 2011

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An electrospinning process was successfully used to fabricate polyethylene oxide/cellulose nanocrystal (PEO/CNC) composite nanofibrous mats. Transition of homogeneous to heterogeneous microstructures was achieved by tailoring the concentration of PEO/CNC mixture in the solution from 5 to 7 wt %. Morphology investigation of the obtained nanofibers demonstrated that rod-shaped CNCs were well-dispersed in the as-spun nanofibers and highly aligned along the nanofiber long-axis. PEO/CNC nanofibers became more uniform and smaller in diameter with increased CNC-loading level. The heterogeneous composite mats were composed of rigid-flexible bimodal nanofibers. Results of structure characterization indicated that the incorporated CNCs interacted strongly with the PEO matrix through hydrogen bonding. Mechanical properties of both types of mats were effectively improved by using CNCs, with heterogeneous mats being stronger than their homogeneous counterparts for all compositions (0-20 wt % CNC contents). When a smaller diameter needle was used to form homogeneous mats, enhanced thermal and mechanical properties were obtained.

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Section: Resultsmentioning

confidence: 99%

Electrospun Polyethylene Oxide/Cellulose Nanocrystal Composite Nanofibrous Mats with Homogeneous and Heterogeneous Microstructures

et al. 2011

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“…The stability of polymer jets could be improved with the increase in molecular entanglements, brought about by the increase in solution viscosity, leading to the reduction of beads and the change of the bead structure (spherical beads to spindle-like beads). But this condition also greatly increased the average fiber diameter [16][17][18][19].…”

Section: Morphology Of Electrospun Ps Nanofibrous Layermentioning

confidence: 98%

Electrospun polystyrene nanofibrous membranes for direct contact membrane distillation

Feldman

Guzman

et al. 2016

Journal of Membrane Science

125

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“…The preparation and formation of nanofibers are dependent on the viscosity of the polymer solution. When the viscosity is lower than the critical value of entanglement, applying a voltage to it may cause sprays or bead-shaped nanofibers [23,24]. When the concentration of the polymer solution is higher than the critical value of entanglement, the amount and size of the bead-shaped fibers decrease, eventually leading to the presence of bead-free fibers [25].…”

Section: Purity and In Vitro Cell Viability Of Skmentioning

confidence: 99%

Polyvinyl Alcohol/Lithospermum Erythrorhizon Nanofibrous Membrane: Characterizations, In Vitro Drug Release, and Cell Viability

Lou

Lee

et al. 2017

Applied Sciences

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Abstract:This study proposes an optimization process of the Lithospermum erythrorhizon (LE) extraction with a higher purity of shikonin (SK). The influence of extraction temperature on the concentration of SK is examined, and an in vitro cell viability assay is used to examine the optimal concentration of SK. Afterwards, polyvinyl alcohol (PVA)/LE solutions at ratios of 90/10, 80/20, and 70/30 w/w are electrospun into LE electrospun nanofibrous membranes (LENMs). The optimal manufacture parameters of LENMs are evaluated based on the test results of in vitro drug release test and cell viability assay. The optimal concentration occurs when the extraction temperature is −10 • C. The purity of the LE extract reaches 53.8% and the concentration of SK is 1.07 mg/mL. Moreover, the cell viability of nanofibrous membranes significantly increases to 136.8% when 0.7 µM SK is used. The diameter of nanofibers of LENM is decreased by 43.9% when the ratio of PVA solution to LE extract is 70/30 (w/w). 80/20 (w/w) LENM has the maximum amount of drug release of 79% for a continuous period of 48 h. In particular, 90/10 (w/w) LENM can create the maximum cell proliferation of 157.5% in a 24-h in vitro cell viability assay. This suggests that LENM has great potential to be used in facilitating tissue regeneration and wound healing.

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Nano-sized beads and porous fiber constructs of Poly(ε-caprolactone) produced by electrospinning

Cited by 89 publications

References 14 publications

Electrospun Polyethylene Oxide/Cellulose Nanocrystal Composite Nanofibrous Mats with Homogeneous and Heterogeneous Microstructures

Electrospun Polyethylene Oxide/Cellulose Nanocrystal Composite Nanofibrous Mats with Homogeneous and Heterogeneous Microstructures

Electrospun polystyrene nanofibrous membranes for direct contact membrane distillation

Polyvinyl Alcohol/Lithospermum Erythrorhizon Nanofibrous Membrane: Characterizations, In Vitro Drug Release, and Cell Viability

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