Nano-sized α and β-TCP powders prepared by high temperature flame spray pyrolysis

Cho, Jung Sang; Jung, Dae Soo; Han, Jin Man

doi:10.1016/j.msec.2008.10.020

Cited by 20 publications

(7 citation statements)

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“…From 600 to 1250°C, it was interpreted as crystallization reaction and phase change. In our work, observation of phase change at about 800°C for higher Ca/P ratios in DTA results suggests the formation of beta-TCP, which is a more stable form of alpha-TCP (Cho et al 2009). The onset of phase transition started at about 500°C according to our TGA results.…”

Section: Discussionsupporting

confidence: 55%

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Synthesis and characterization of nanosized calcium phosphates by flame spray pyrolysis, and their effect on osteogenic differentiation of stem cells

et al. 2015

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The present study evaluates the synthesis of biocompatible osteoconductive and osteoinductive nano calcium phosphate (CaP) particles by industrially applied, aerosol-derived flame spray pyrolysis method for biomedical field. Calcium phosphate nanoparticles were produced in a range of calciumto-phosphorus ratio, (1.20-2.19) in order to analyze the morphology and crystallinity changes, and to test the bioactivity of particles. The characterization results confirmed that nanometer-sized, spherical calcium phosphate particles were produced. The average primary particle size was determined as 23 nm by counting more than 500 particles in TEM pictures. XRD patterns, HRTEM, SAED, and SEM analyses revealed the amorphous nature of the asprepared nano calcium phosphate particles at low Ca/P ratios. Increases in the specific surface area and crystallinity were observed with the increasing Ca/P ratio. TGA-DTA analysis showed that the thermally stable crystal phases formed after 700°C. Cell culture studies were conducted with urine-derived stem cells that possess the characteristics of mesenchymal stem cells. Synthesized amorphous nanoparticles did not have cytotoxic effect at 5-50 lg/ml concentration range. Cells treated with the as-prepared nanoparticles had higher alkaline phosphatase (ALP) enzyme activity than control cells, indicating osteogenic differentiation of cells. A slight decrease in ALP activity of cells treated with two highest Ca:P ratios at 50 lg/ml concentration was observed at day 7. The findings suggest that calcium phosphate nanoparticles Guest Editors: Mustafa Culha, Rawil F. Fakhrullin, Ratnesh Lal This article is part of the topical collection on Nanobiotechnology Electronic supplementary material The online version of this article

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Section: Discussionsupporting

confidence: 55%

“…However, the low temperature affects the reaction efficiency and leads to impurity of different phases of calcium phosphates. Meanwhile, the reaction results with low crystalline particles (Cho et al 2009). Dry-based solid-state synthesis method involves mixing of precursor's powder.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of nanosized calcium phosphates by flame spray pyrolysis, and their effect on osteogenic differentiation of stem cells

et al. 2015

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“…To synthesize nano-sized TCP, other techniques, such as milling [529,530], a high temperature flame spray pyrolysis [531] and pulsed laser ablation [532], might be employed as well. Afterwards, the nanodimensional β-TCP powders can be compacted into 3D specimens, followed by sintering to achieve the appropriate mechanical strength [173].…”

Section: Nanodimensional and Nanocrystalline Tcpmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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“…To synthesize TCP, both milling [427,428] and a high temperature flame spray pyrolysis [429] techniques might be employed as well. Afterwards, the nanodimensional β-TCP powders can be compacted into 3D specimens, followed by sintering to achieve the appropriate mechanical strength [161].…”

Section: Synthesis Of the Nanodimensional And Nanocrystalline Calcmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine

Dorozhkin¹

2009

Materials

246

150

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Recent developments in biomineralization have already demonstrated that nanosized particles play an important role in the formation of hard tissues of animals. Namely, the basic inorganic building blocks of bones and teeth of mammals are nanodimensional and nanocrystalline calcium orthophosphates (in the form of apatites) of a biological origin. In mammals, tens to hundreds nanocrystals of a biological apatite were found to be combined into self-assembled structures under the control of various bioorganic matrixes. In addition, the structures of both dental enamel and bones could be mimicked by an oriented aggregation of nanosized calcium orthophosphates, determined by the biomolecules. The application and prospective use of nanodimensional and nanocrystalline calcium orthophosphates for a clinical repair of damaged bones and teeth are also known. For example, a greater viability and a better proliferation of various types of cells were detected on smaller crystals of calcium orthophosphates. Thus, the nanodimensional and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the field of hard tissue engineering starting from bone repair and augmentation to the controlled drug delivery devices. This paper reviews current state of knowledge and recent developments of this subject starting from the synthesis and characterization to biomedical and clinical applications. More to the point, this review provides possible directions of future research and development.

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Nano-sized α and β-TCP powders prepared by high temperature flame spray pyrolysis

Cited by 20 publications

References 11 publications

Synthesis and characterization of nanosized calcium phosphates by flame spray pyrolysis, and their effect on osteogenic differentiation of stem cells

Synthesis and characterization of nanosized calcium phosphates by flame spray pyrolysis, and their effect on osteogenic differentiation of stem cells

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine

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