Nano-Sponge Novel Drug Delivery System as Carrier of Anti-Hypertensive Drug

El-Assal, Mona I.A.

doi:10.22159/ijpps.2019v11i10.34812

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…For example, G1 showed a LX release of 50.78% and generated 66.63% edema inhibition at 3 h. G0 released 32.82% of LX and generated only 42.11% edema inhibition at the same time. Furthermore, G1 produced the maximum edema inhibition at 5 h (92.91%) in correlation with 69.25% of LX released achieving a controlled anti-inflammatory response [38]. The findings support that nanosponges improved skin permeation and consequently enhanced the anti-inflammatory response [39].…”

Section: Discussionsupporting

confidence: 65%

Lornoxicam-Loaded Nanosponges for Controlled Anti-Inflammatory Effect: In Vitro/in Vivo Assessment

Shawky¹,

Khalifa²,

Eassa³

2020

Int J App Pharm

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Objective: To design a controlled topical delivery system of lornoxicam (LX) in order to enhance skin permeation and treatment efficacy. Nanosponges were selected as a novel carrier for this purpose. Methods: Nanosponges were formulated via the emulsion solvent evaporation method using ethyl cellulose (polymer) and polyvinyl alcohol (surfactant). Nanosponge dispersions were characterized for colloidal properties, entrapment efficiency and in vitro release study. The nanosponge formulation (LS1) was then incorporated into carboxymethyl cellulose sodium hydrogels and evaluated for pH, viscosity and in vitro drug release. Skin irritation was evaluated, and anti-inflammatory activity was assessed via rat hind paw edema method. Results: Nanosponges were in the nano-sized range and attained a uniform round shape with a spongy structure. LS1exhibited the highest LX release after 6 h, so it was incorporated as hydrogel. Formulated hydrogels showed acceptable physicochemical parameters (pH, drug content and rheological properties). Skin irritation testing proved LX-loaded nanosponge hydrogel formulation (G1) to be non-irritant. In vivo study revealed an enhanced anti-inflammatory activity of G1 for 6 h (p<0.001). Conclusion: The developed nanosponge hydrogel is an efficient nanocarrier for improved and controlled topical delivery of LX.

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Section: Discussionsupporting

confidence: 65%

Lornoxicam-Loaded Nanosponges for Controlled Anti-Inflammatory Effect: In Vitro/in Vivo Assessment

Shawky¹,

Khalifa²,

Eassa³

2020

Int J App Pharm

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“…The valid nanosponges mean particle size ranged from 62.89±7.69 to 533.2±18.12 nm. The mean particle size was found to increase with an increase in polymer amount [31]. This may be due to the availability of a large quantity of polymer.…”

Section: Effect Of Formulation Variables On the Physicochemical Chara...mentioning

confidence: 91%

Loxoprofen Nanosponges: Formulation, Characterization and Ex-Vivo Study

et al. 2022

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Objective: The objective of this study is to optimize a nanosponge formulation for Loxoprofen and then incorporating it into a gel formulation offering a controlled drug release, enhanced skin permeation and thus better bioavailability. Methods: Loxoprofen nanosponges were prepared using the emulsion solvent diffusion method and formulated using Polyvinyl alcohol, Ethylcellulose and Dichloromethane. The effect of the different formulation variables like ethyl cellulose: polyvinyl alcohol ratio, drug: ethyl cellulose ratio, stirring time, stirring speed, internal phase volume and external phase volume on the particle size, entrapment efficiency, production yield, polydispersity index and Zeta potential was investigated. The optimized nanosponge formulation was incorporated into a gel. The loaded gel was evaluated by in vitro release and permeation studies and the results were compared to that of a marketed formulation (Loxonin® gel). Results: The optimized formulation showed 67.29±1.19 % entrapment efficiency, 239.8±16.95 nm particle size and-8.32±0.87 mV Zeta potential. The drug was released slowly from the nanosponge-loaded gel where the cumulative percentage of drug released was only 77.71±0.42 % in 8 h where it was incorporated in the entrapped form while it was 99.31±0.64% from Loxonin® gel where it was in the unentrapped form. The cumulative percent of drug permeated through the skin from the nanosponge-loaded gel was 98.66±0.14% for 24 h while it was only 60.38±0.18% from Loxonin® gel. Conclusion: The nanosponge-loaded gel showed more sustained drug release and a better drug permeation when compared to a marketed gel (Loxonin® gel).

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“…The spherical nanoparticles with uniform dispersion are readily visible in the FESEM and HRTEM micrographs. NiO nanoparticles' multifunctional applications, such as anticorrosive, photocatalytic, and antibacterial properties, are also investigated [63,64]. Green synthesis had a greater impact on the antibacterial properties of NiO nanoparticles against Staphylococcus aureus and Escherichia coli.…”

Section: Nickel Oxide (Nio) Nanoparticlesmentioning

confidence: 99%

A Review on Nanoparticles of Moringa Oleifera Extract: Preparation, Characterization, and Activity

MUHAIMIN,

CHAERUNISAA,

ROSTINAWATI

et al. 2023

Int J App Pharm

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Nanoparticles have revolutionized biomedicine, especially in the field of drug delivery due to their intriguing properties such as systemic stability, level of solubility, and target site specificity. It can, however, be both beneficial and damaging depending on the properties in different environments, thus highlighting the importance of nanotoxicology studies before use in humans. Green nanotechnology has drawn major attention because of its ecofriendly and economical biosynthetic protocols. Synthesis of metallic nanoparticles (NPs) using plant secondary metabolites is considered as a safer and cheaper option. Metallic nanoparticles (NPs) have a great role in many scientific fields such as medicine, physics, mechanics, pharmaceutics, and other. Plants contain phytochemicals that has been used traditionally for the treatment of various diseases, and proved to be nontoxic to healthy tissues. These phytochemicals play an important role in bio-reduction processes as reducing and stabilizing agents and renders NPs selective toxicity towards diseased tissues. This review focuses on the synthesis of certain metal and metal oxide nanoparticles (M/MO NPs) using an extract of Moringa oleifera plant. Moringa oleifera is an example of a tree with significant nutritional and therapeutic benefits. It is abundant in macronutrients, micronutrients, and other bioactive components that are essential for optimal bodily function and disease prevention. These components produce smaller particles and give a compelling impact on the activities of M/MO nanoparticles. This review paper is an attempt to compile up various research as well as reports related to nanoparticles such as FeO, CuO, ZnO, NiO, MgO, Ag, and Au.

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Nano-Sponge Novel Drug Delivery System as Carrier of Anti-Hypertensive Drug

Cited by 6 publications

References 26 publications

Lornoxicam-Loaded Nanosponges for Controlled Anti-Inflammatory Effect: In Vitro/in Vivo Assessment

Lornoxicam-Loaded Nanosponges for Controlled Anti-Inflammatory Effect: In Vitro/in Vivo Assessment

Loxoprofen Nanosponges: Formulation, Characterization and Ex-Vivo Study

A Review on Nanoparticles of Moringa Oleifera Extract: Preparation, Characterization, and Activity

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