Nano-zirconia – Evaluation of its antioxidant and anticancer activity

Characteristics and local structure of hafnia-silicate-zirconate ceramic nanomixtures

“…The appearance of the UV absorption band centered at about 265 nm indicates the formation of tetragonal ZrO 2 phase (Balaji et al, 2017). By increasing the Y 2 O 3 content, the intensity of this band increases.…”

A Review on Plant Extract Mediated Green Synthesis of Zirconia Nanoparticles and Their Miscellaneous Applications

“…Nowadays, green synthesis of metal oxide nanomaterial has been an emerging research area in the field of nanobiotechnology. The significance of the green synthesis ( Figure 2) over chemical and physical methods is: one pot and clean synthesis, environmental friendly, cost effective, swift, facile and easily scaled up for large scale syntheses of nanoparticles, furthermore there is no need to use high amount of temperature, energy, pressure and toxic chemicals [38][39]. The utilization of plant material for the fabrication of ZrO2 NPs has received lots of attention due to its environmentally gracious, simple, rapid, non-toxic, economical protocol, providing a single step technique for the green synthesis processes [26,38].…”

“…Moreover, Mandal and co-workers demonstrated the Eucalyptus globulus leaf extract mediated ZrO2 NPs were in the range of 9-11 nm. They reported their excellent antioxidant activity up to 85.6% scavenging inhibition of free radicals liberated by DPPH molecule and anticancer activity against human lung carcinoma A-549 and human colon carcinoma HCT-116 cell lines [39]. From the antioxidant and anticancer studies, ZrO2 NPs will be useful in many potential biomedical applications.…”

“…Therefore, ZrO2 NPs have been widely used in myriad applications ( Figure 1), including bone implants [32], dental [33], photocatalysis, refractory, energy [26], fuel cell [34], gas sensor [35], solar cells [36], and seed germination [37]. Therewithal ZrO2 NPs have antibacterial, antifungal, antioxidant and anticancer properties because of their unusual physiochemical properties [37][38][39]. Generally, ZrO2 NPs have three crystal phases, that is, the monoclinic (m-ZrO2) phase is thermodynamically stable at room temperature, the tetragonal (t-ZrO2) phase exist in the temperature range between 1100-2370 ˚C and the cubic (c-ZrO2) phase is fond to stable above 2370 ˚C [40].…”

“…This enhances the urgent need to replace chemical preparation methodology and develop a simple, clean, non-toxic, and environmentally benign process through green synthesis and other biological approaches. Some studies conducted on green synthesis of ZrO2 NPs using microorganisms including bacteria [64][65] and plants [26,[37][38][39]. However, among the numerous biological routes of ZrO2 NPs synthesis, microbe mediated synthesis is not a quite simple and suitable for industrial feasibility because of necessities of highly aseptic conditions and their maintenance.…”