Nanoagent‐Promoted Mild‐Temperature Photothermal Therapy for Cancer Treatment

Gao, Ge; Sun, Xianbao; Liang, Gaolin

doi:10.1002/adfm.202100738

Cited by 217 publications

(140 citation statements)

References 168 publications

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“…As it well known, heat causes irreversible damage to cancer cell membranes and initiates protein denaturation [ 16 , 41 ]. In order to avoid unnecessary thermal effect to proximal normal tissues, the temperature of PTT was held around 45 °C [ 42 , 43 ]. The temperature changes of the tumor area were recorded by IR thermal mapping apparatus.…”

Section: Resultsmentioning

confidence: 99%

Semiconducting polymer nano-radiopharmaceutical for combined radio-photothermal therapy of pancreatic tumor

Shi

Zhang

et al. 2021

J Nanobiotechnol

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Background Pancreatic ductal adenocarcinoma (PDAC) is a devastatingly malignant tumor with a high mortality. However, current strategies to treat PDAC generally have low efficacy and high side-effects, therefore, effective treatment against PDAC remains an urgent need. Results We report a semiconducting polymer nano-radiopharmaceutical with intrinsic photothermal capability and labeling with therapeutic radioisotope 177Lu (177Lu-SPN-GIP) for combined radio- and photothermal therapy of pancreatic tumor. 177Lu-SPN-GIP endowed good stability at physiological conditions, high cell uptake, and long retention time in tumor site. By virtue of combined radiotherapy (RT) and photothermal therapy (PTT), 177Lu-SPN-GIP exhibited enhanced therapeutic capability to kill cancer cells and xenograft tumor in living mice compared with RT or PTT alone. More importantly, 177Lu-SPN-GIP could suppress the growth of the tumor stem cells and reverse epithelial mesenchymal transition (EMT), which may greatly reduce the occurrence of metastasis. Conclusion Such strategy we developed could improve therapeutic outcomes over traditional RT as it is able to ablate tumor with relatively lower doses of radiopharmaceuticals to reduce its side effects. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Semiconducting polymer nano-radiopharmaceutical for combined radio-photothermal therapy of pancreatic tumor

Shi

Zhang

et al. 2021

J Nanobiotechnol

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show abstract

“…As it well known, heat causes irreversible damage to cancer cell membranes and initiates protein denaturation [16,39]. In order to avoid unnecessary thermal effect to proximal normal tissues, the temperature of PTT was held around 45°C [40,41]. The temperature changes of the tumor area were recorded by IR thermal mapping apparatus.…”

Section: In Vivo Therapeutic Effect Of Combined Rt and Pttmentioning

confidence: 99%

Semiconducting Polymer Nano-Radiopharmaceutical For Combined Radio-Photothermal Therapy of Pancreatic Tumor

Shi¹,

Li²,

Zhang³

et al. 2021

Preprint

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Background: Pancreatic ductal adenocarcinoma (PDAC) is a devastatingly malignant tumor with a high mortality. However, current strategies to treat PDAC generally have low efficacy and high side-effects, therefore, effective treatment against PDAC remains an urgent need. Results: We report a semiconducting polymer nano-radiopharmaceutical with intrinsic photothermal capability and labeling with therapeutic radioisotope 177Lu (177Lu-SPN-GIP) for combined radio- and photothermal therapy of pancreatic tumor. 177Lu-SPN-GIP endowed good stability at physiological conditions, high cell uptake, and long retention time in tumor site. By virtue of combined radiotherapy (RT) and photothermal therapy (PTT), 177Lu-SPN-GIP exhibited enhanced therapeutic capability to kill cancer cells and xenograft tumor in living mice compared with RT or PTT alone. More importantly, 177Lu-SPN-GIP could suppress the growth of the tumor stem cells and reverse epithelial mesenchymal transition (EMT), which may greatly reduce the occurrence of metastasis. Conclusion: Such strategy we developed could improve therapeutic outcomes over traditional RT as it is able to ablate tumor with relatively lower doses of radiopharmaceuticals to reduce its side effects.

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“…Moreover, photothermal agents with high concentration in tumor or high NIR laser intensity is required to generate hyperthermia, which may increase health risks due to drug overdose or photodamage. Recently, mild temperature hyperthermia (< 48 ℃) has attracted great attention due to the excellent tolerance and safety for surrounding tissues [ 10 – 12 ]. However, the weak treatment effectiveness of mild temperature hyperthermia limited the application in tumor treatment.…”

Section: Introductionmentioning

confidence: 99%

Mn doped Prussian blue nanoparticles for T1/T2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor

Tao

et al. 2022

J Nanobiotechnol

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Background Combining the multimodal imaging and synergistic treatment in one platform can enhance the therapeutic efficacy and diagnosis accuracy. Results In this contribution, innovative Mn-doped Prussian blue nanoparticles (MnPB NPs) were prepared via microemulsion method. MnPB NPs demonstrated excellent T1 and T2 weighted magnetic resonance imaging (MRI) enhancement in vitro and in vivo. The robust absorbance in the near infrared range of MnPB NPs provides high antitumor efficacy for photothermal therapy (PTT) and photoacoustics imaging property. Moreover, with the doping of Mn, MnPB NPs exhibited excellent Fenton reaction activity for chemodynamic therapy (CDT). The favorable trimodal imaging and Fenton reaction enhanced mild temperature photothermal therapy in vitro and in vivo were further confirmed that MnPB NPs have significant positive effectiveness for integration of diagnosis and treatment tumor. Conclusions Overall, this Mn doped Prussian blue nanoplatform with multimodal imaging and chemodynamic/mild temperature photothermal co-therapy provides a reliable tool for tumor treatment. Graphical Abstract

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Nanoagent‐Promoted Mild‐Temperature Photothermal Therapy for Cancer Treatment

Cited by 217 publications

References 168 publications

Semiconducting polymer nano-radiopharmaceutical for combined radio-photothermal therapy of pancreatic tumor

Semiconducting polymer nano-radiopharmaceutical for combined radio-photothermal therapy of pancreatic tumor

Semiconducting Polymer Nano-Radiopharmaceutical For Combined Radio-Photothermal Therapy of Pancreatic Tumor

Mn doped Prussian blue nanoparticles for T1/T2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor

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