Nanoarchitectonics of Fullerene‐Based Enzyme Mimics for Osteogenic Induction of Stem Cells

Yeniterzi, Dilara; Demirsoy, Zeynep; Saylam, Aytül; Özçubukçu, Salih; Gülseren, Gülcihan

doi:10.1002/mabi.202270025

Cited by 1 publication

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“…Phosphatases play an essential role in bone regeneration and their external administration advances the formation of such tissues. [ 16,17 ] While these enzymes are widely employed in osteoregeneration studies, low‐stability problems must be solved in order to enable long‐term bioactivity. [ 18 ] Synthetic enzymes have thus emerged as a viable and multifunctional alternative to natural ones.…”

Section: Introductionmentioning

confidence: 99%

“…[ 19 ] Recently, fullerene has been recognized as a powerful artificial enzyme‐mimicking tool due to its surface characteristics and biocompatible nature. [ 17,20–22 ] To this end, histidine and threonine functionalized fullerene nanoparticles (HT) have been utilized for phosphatase activity. The study from our group further demonstrated the phosphatase‐mimicking capacity of such nanocatalysts with tunable bioactivity for both phosphomonoesterase and phosphodiesterase substrates (Figures S3 and S4, Supporting Information).…”

Section: Introductionmentioning

confidence: 99%

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Bioinspired Multi‐Layer Biopolymer‐Based Dental Implant Coating for Enhanced Osseointegration

Üzülmez

Demirsoy

Can

et al. 2023

Macromolecular Bioscience

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The major drawbacks of metal‐based implants are weak osseointegration and post‐operational infections. These limitations restrict the long‐term use of implants that may cause severe tissue damage and replacement of the implant. Recent strategies to enhance the osseointegration process require an elaborate fabrication process and suffer from post‐operative complications. To address the current challenges taking inspiration from the extracellular matrix (ECM), the current study is designed to establish enhanced osseointegration with lowered risk of infection. Natural biopolymer pectin, peptide amphiphiles, and enzyme‐mimicking fullerene moieties are governed to present an ECM‐like environment around the implant surfaces. This multifunctional approach promotes osseointegration via inducing biomineralization and osteoblast differentiation. Application of the biopolymer‐based composite to the metal surfaces significantly enhances cellular attachment, supports the mineral deposition, and upregulates osteoblast‐specific gene expression. In addition to the osteoinductive properties of the constructed layers, the inherent antimicrobial properties of multilayer coating are also used to prevent infection possibility. The reported biopolymer‐artificial enzyme composite demonstrates antimicrobial activity against Escherichia coli and Bacillus subtilis as a multifunctional surface coating.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%