Nanoarchitectonics to prepare practically useful artificial enzymes

Komiyama, Makoto; Ariga, Katsuhiko

doi:10.1016/j.mcat.2019.110492

Cited by 46 publications

(27 citation statements)

References 264 publications

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“…[ 1,2 ] For instance, energized by the enzyme structures and by understanding their functions in catalyzing the biological reactions, several artificial enzymes or enzyme mimetics have been synthesized. [ 3–6 ] The main objective of developing these synthesis methods is to overcome the limitations of extracting, purifying, and storing the natural enzymes due to the high costs, along with the susceptibility of these protein structures to inhibition under different conditions. [ 7,8 ] Over the last two decades, numerous artificial enzymes in the form of composite structures have been developed to mimic the functionality of, for instance, peroxidases, [ 9,10 ] cytochrome P450, [ 11,12 ] superoxide dismutase, [ 13 ] and catalase.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Design and Sensing Applications of Hemin/Coordination Polymer‐Based Nanocomposites

2020

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The fabrication of biomimetic catalysts as substituents for enzymes is of critical interest in the field due to the problems associated with the extraction, purification, and storage of enzymes in sensing applications. Of these mimetics, hemin/coordination polymer‐based nanocomposites, mainly hemin/metal–organic frameworks (MOF), have been developed for various biosensing applications because of the unique properties of each component, while trying to mimic the normal biological functions of heme within the protein milieu of enzymes. This critical review first discusses the different catalytic functions of heme in the body in the form of enzyme/protein structures. The properties of hemin dimerization are then elucidated with the supposed models of hemin oxidation. After that, the progress in the fabrication of hemin/MOF nanocomposites for the sensing of diverse biological molecules is discussed. Finally, the challenges in developing this type of composites are examined as well as possible proposals for future directions to enhance the sensing performance in this field further.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in the Design and Sensing Applications of Hemin/Coordination Polymer‐Based Nanocomposites

2020

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“…Nanoarchitectonics represents today a promising and powerful strategy in which the LB method yields a perfectly molecular organization within a 2D plane [295,296]. Therefore, because of the wide generality of the nanoarchitectonics concept, LB films can also be applied to a wide range of research fields with practical importance, such as materials production [297][298][299], sensing [300,301], catalysis [302,303], device [304,305], energy [306][307][308][309][310], or biological/biomedical applications [311][312][313][314], or even in the fabrication of smart textile-based sensors (TEX sensors) [311]. These studies underscore the almost limitless possibilities of the LB technique to fabricate well-ordered 2D films of a wide range of materials.…”

Section: The Langmuir-blodgett Techniquementioning

confidence: 99%

Nanofabrication Techniques in Large-Area Molecular Electronic Devices

2020

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The societal impact of the electronics industry is enormous—not to mention how this industry impinges on the global economy. The foreseen limits of the current technology—technical, economic, and sustainability issues—open the door to the search for successor technologies. In this context, molecular electronics has emerged as a promising candidate that, at least in the short-term, will not likely replace our silicon-based electronics, but improve its performance through a nascent hybrid technology. Such technology will take advantage of both the small dimensions of the molecules and new functionalities resulting from the quantum effects that govern the properties at the molecular scale. An optimization of interface engineering and integration of molecules to form densely integrated individually addressable arrays of molecules are two crucial aspects in the molecular electronics field. These challenges should be met to establish the bridge between organic functional materials and hard electronics required for the incorporation of such hybrid technology in the market. In this review, the most advanced methods for fabricating large-area molecular electronic devices are presented, highlighting their advantages and limitations. Special emphasis is focused on bottom-up methodologies for the fabrication of well-ordered and tightly-packed monolayers onto the bottom electrode, followed by a description of the top-contact deposition methods so far used.

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“…These not only give rise to the complicated catalytic mechanisms, but also result in multiple catalytic pathways and enzyme-like activities. [42][43][44][45][46][47][48] Thus it is extremely difficult to promote the enzyme-like specicity, distinguish the actual active sites and as well as investigate the origin of enzyme-like activity for nanozymes. It is urgent for nanozyme technologies to get out of the current predicament.…”

Section: Introductionmentioning

confidence: 99%