Nanoarchitectured Structure and Surface Biofunctionality of Mesoporous Silica Nanoparticles

Abstract

Mesoporous silica nanoparticles (MSNs), one of the important porous materials, have garnered interest owing to their highly attractive physicochemical features and advantageous morphological attributes. They are of particular importance for use in diverse fields including, but not limited to, adsorption, catalysis, and medicine. Despite their intrinsic stable siliceous frameworks, excellent mechanical strength, and optimal morphological attributes, pristine MSNs suffer from poor drug loading efficiency, as well as compatibility and degradability issues for therapeutic, diagnostic, and tissue engineering purposes. Collectively, the desirable and beneficial properties of MSNs have been harnessed by modifying the surface of the siliceous frameworks through incorporating supramolecular assemblies and various metal species, and through incorporating supramolecular assemblies and various metal species and their conjugates. Substantial advancements of these innovative colloidal inorganic nanocontainers drive researchers in promoting them toward innovative applications like stimuli (light/ultrasound/magnetic)‐responsive delivery‐associated therapies with exceptional performance in vivo. Here, a brief overview of the fabrication of siliceous frameworks, along with discussions on the significant advances in engineering of MSNs, is provided. The scope of the advancement in terms of structural and physicochemical attributes and their effects on biomedical applications with a particular focus on recent studies is emphasized. Finally, interesting perspectives are recapitulated, along with the scope toward clinical translation.

An Overview on SARS-CoV-2 (COVID-19) and Other Human Coronaviruses and Their Detection Capability via Amplification Assay, Chemical Sensing, Biosensing, Immunosensing, and Clinical Assays

“…Because of this, it is possible to alter the biological function of these nanomaterials toward the site detecting of target molecules through multiple interactions and actively targeted imaging for sensing and diagnosis of viral infections [ 88 ]. The most common metal nanoparticles that have been used to treat viral infection or their detection are silver NPs [ 89 ], gold NPs [ 90 , 91 ], silica and mesoporous [ 88 , 92 – 94 ], carbon nanotubes [ 95 , 96 ], iron oxide NPs [ 97 ], etc.…”

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

“…Considering the aforementioned, MSNs are very attractive as nanocarriers/nanotherapeutics because their interesting properties such as chemical and physical stabilities, size, morphology, surface and pores structures can be easily modulated to achieve good biological behavior and also effective drug loading and delivery at the desired site, comprising efficient nanoplatforms in most of pre-clinical assays. Internal, external or multi stimuli-responsive MSNs controlled drug delivery systems have been designed as smart nanoarchitectures that control pharmacokinetics parameters and emphasize the amazing properties of MSNs, stimulating researches towards their application in clinical trials (12,160,161).…”

Fractionation of block copolymers for pore size control and reduced dispersity in mesoporous inorganic thin films

“…10,11 Besides the mean pore size, the resulting pore dispersity is another important material property, as evidenced in examples related to electrochemistry, 2 sensing, 12,13 and controlled release. 14,15 This is best showcased in mass transport-limited scenarios governed by the Knudsen diffusion. 16,17 To this end, block copolymer (BCP) based co-assembly represents a promising bottom-up approach to create ordered mesoporous structures with tunable size and morphology.…”