Nanobiohybrids as delivery vehicles for camptothecin

Tyner, Katherine M.; Schiffman, Scott; Giannelis, Emmanuel P.

doi:10.1016/j.jconrel.2003.12.027

Cited by 245 publications

(178 citation statements)

References 19 publications

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“…When pH < 7, the surface hydroxide layer starts protonation (Eq. (2)) and dissolution [24]. This will increase the zeta potential of LDH particles [22], particularly for Mg 2 Al-LDH system, as observed in this research.…”

Section: Ph Effect On the Zeta Potentialsupporting

confidence: 65%

“…The irreversibility of the zeta potential in the back and forth titration is expected to be mainly due to the ionic strength effect as well as the possible dissolution at pH < 6. For Mg 2 Al-LDH system, the zeta potential reading became not stable when pH was tried to reach below 5 or above 12, which is presumably caused by the dissolution of LDH at pH below 5 [24] or the Al 3+ leaching from the layers at pH above 12.…”

Section: Ph Effect On the Zeta Potentialmentioning

confidence: 99%

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Surface charging of layered double hydroxides during dynamic interactions of anions at the interfaces

Jin

Liu

et al. 2008

Journal of Colloid and Interface Science

129

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In this research, we investigated the effect of dynamic anion adsorption/exchange on the surface charging property of Mg 2 Al-Cl-LDH and Mg 2 Al-CO 3 -LDH particles that show the average zeta potential of 41 and 34 mV in the as-prepared suspension, respectively. The addition of NaCl up to 3 × 10 −3 M in the suspension does not obviously affect the zeta potential of both LDHs, which can be attributed to the less affinity of Cl − to LDH. The introduction of Na 2 CO 3 severely reduces the zeta potential at the CO 2− 3 concentration higher than 1 × 10 −4 M, and to the negative value in both LDH systems at ca. 2 × 10 −3 M, which is presumably resulted from the exchange and the re-orientation of CO 2− 3 in a tilt/vertical style on the surface. All four organic anions (dodecyl sulfate, folate, citrate and polyacrylate) also significantly affect the zeta potential of the LDH particles. At the lower concentrations of organic anionic groups (<1 × 10 −4 M), the zeta potential was slightly affected, i.e. limited exchange/adsorption. However, the concentration increasing to some point suddenly decreases and reverses the zeta potential of the LDH particles, which is presumably caused by the hydrophobic interactions that bind the hydrophobic hydrocarbon chains (especially in dodecyl sulfate) into the micelle-like bilayer bunches on the LDH surface. In addition, the effect of pH in 5.5-11.0 on the LDH particle surface charging is mainly reflected through the conversion of CO 2− 3 to HCO − 3 /H 2 CO 3 when pH decreases from ca. 11 to 6, with limited contribution from protonation/deprotonation and exchange/adsorption.

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Section: Ph Effect On the Zeta Potentialsupporting

confidence: 65%

Section: Ph Effect On the Zeta Potentialmentioning

confidence: 99%

Surface charging of layered double hydroxides during dynamic interactions of anions at the interfaces

Jin

Liu

et al. 2008

Journal of Colloid and Interface Science

129

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“…Metal NPs and their oxides have a considerable number of present and future applications in the medical and industrial fields [11]. Among the various metal nanomaterials, zinc oxide nanoparticles (ZNP) are used in several products such as sunscreens, biosensors, food additives, pigments, rubber manufacture, and electronic materials [12].…”

Section: Introductionmentioning

confidence: 99%

The effect of zinc oxide nanoparticles on mouse spermatogenesis

Talebi

Khorsandi

Moridian³

2013

J Assist Reprod Genet

127

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Objective To evaluate the effects of zinc oxide nanoparticles on mouse spermatogenesis. Methods Thirty two adult male NMRI mice were used. Experimental Groups (ZNP-1-ZNP-3) received one of the following treatments daily for 35 days: 5, 50 and 300 mg/kg zinc oxide nanoparticles respectively. Control group received only distilled water. Epididymal sperm parameters, testicular histopathology, morphometric analysis and spermatogenesis assessments were performed for evaluation of the zinc oxide nanoparticles effects on testis. Results Epididymal sperm parameters including sperm number, motility and percentage of abnormality were significantly changed in 50 and 300 mg/kg zinc oxide nanoparticles treated mice (p<0.01). Histopathological criteria such as epithelial vacuolization, sloughing of germ and detachment were significantly increased in 50 and 300 mg/kg zinc oxide nanoparticles treated mice (p<0.001). 300 mg/kg zinc oxide nanoparticles induced formation of multinucleated giant cells in the germinal epithelium. 50 and 300 mg/kg zinc oxide nanoparticles also caused a significant decrease in seminiferous tubule diameter, seminiferous epithelium height and maturation arrest (p<0.001). Conclusion Zinc oxide nanoparticles act as testicular toxicant and further studies are needed to establish its mechanism of action upon spermatogenesis.

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“…Various approaches have been reported in literature in order to reduce these severe systemic toxicities and enhance antitumor effects of CPT. These includes conjugation to synthetic polymers [28][29][30][31], incorporation into liposomes [32,33], microspheres [34,35], nanohybrids [36], and polymeric micelles [37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Mixed PEG–PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: Improved drug solubilization and enhanced in vitro cytotoxicity

Sawant

Torchilin

2008

European Journal of Pharmaceutics and Biopharmaceutics

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Two poorly soluble, potent anticancer drugs, paclitaxel and camptothecin, were successfully solubilized by mixed micelles of polyethylene glycol-phosphatidyl ethanolamine (PEG-PE) and vitamin E. Drug containing micelles were additionally modified with anti-nucleosome monoclonal antibody 2C5 (mAb 2C5), which can specifically bring micelles to tumor cells in vitro. The optimized micelles had an average size of about 13-to-22 nm and the immuno-modification of micelles did not significantly change it. The solubilization of both drugs by the mixed micelles was more efficient than by micelles made of PEG-PE alone. Solubilization of camptothecin in micelles prevented also the hydrolysis of active lactone form of the drug to inactive carboxylate form. Drug loaded mixed micelles and mAb 2C5-immunomicelles demonstrated significantly higher in vitro cytotoxicity than free drug against various cancer cell lines.

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Nanobiohybrids as delivery vehicles for camptothecin

Cited by 245 publications

References 19 publications

Surface charging of layered double hydroxides during dynamic interactions of anions at the interfaces

Surface charging of layered double hydroxides during dynamic interactions of anions at the interfaces

The effect of zinc oxide nanoparticles on mouse spermatogenesis

Mixed PEG–PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: Improved drug solubilization and enhanced in vitro cytotoxicity

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