Nanobiomaterials for Bone Tissue Engineering

Lowe, Baboucarr; Guastaldi, Fernando Pozzi Semeghini; Müller, M. G.; Gootkind, F.; Troulis, Maria J.; Ye, Qingsong

doi:10.1007/978-981-13-8855-2_4

Cited by 3 publications

(1 citation statement)

References 88 publications

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“…Increasing research interest in the exploitation of diatom biosilica comes from its varied 3D architecture currently unmatched by human engineering, mechanical and thermal inertness, relative straightforward chemical surface modifications, biocompatibility, stability, high specific surface area and regular pours structures. All these features have rendered diatoms very attractive as materials in a variety of applications, including wastewater treatment [17][18][19], bioremediation [19][20][21], tissue engineering [22,23] or catalysis [24]. The periodically nanostructured pore arrays of the diatoms, in particular, are responsible for the optical signal enhancement in fluorescence and Raman biosensing applications.…”

Section: Introductionmentioning

confidence: 99%

Diatom Biosilica in Targeted Drug Delivery and Biosensing Applications: Recent Studies

Zobi

2022

Micro

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Diatoms are single-cell algae encased in a cell wall (named frustule) composed of transparent, biogenic (or opaline) silica with intricate and strikingly regular patterns. Over the past 30 years, these microorganisms have proven to be a valuable replacement for synthetic silica that satisfies numerous pharmaceutical requirements for the realization of drug delivery vectors, biosensing supports and photonic crystals. It is not only the structural features of the diatoms, but also the possibility of chemically modifying the frustule that permits the relatively straightforward transformation of the biosilica into potential devices for biomedical applications. In this short review, we explore the applications of diatoms-derived biosilica in the drug delivery and biosensing fields. Specifically, we consider the use of diatoms for the targeted delivery of anticancer and antibiotic drugs and how the same microalgae are employed in the fabrications of biosensors whose analyte signal response is evaluated via fluorescence and surface-enhanced Raman scattering techniques. We limit our discussion to studies published in the last seven years, with the intention of minimizing possible redundancy with respect to previously published contributions.

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