Nanocapsule formation by interfacial polymer deposition following solvent displacement

Fessi, Hatem; Puisieux, F.; Devissaguet, Jean‐Philippe; Ammoury, Nazih; Benita, S.

doi:10.1016/0378-5173(89)90281-0

Cited by 1,950 publications

(1,261 citation statements)

References 7 publications

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“…28 Nanoparticles were produced by the solvent displacement method (i.e., nanoprecipitation) 29,30 in which the polymer is dissolved in a solvent miscible with water (e.g., DMF) (oil phase), which is added to water, leading to the formation of droplets. Solvent diffusion results in a supersaturated oil phase, causing the formation of smaller droplets and a meta-stable emulsion.…”

Section: Resultsmentioning

confidence: 99%

Boron Polylactide Nanoparticles Exhibiting Fluorescence and Phosphorescence in Aqueous Medium

et al. 2008

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Difluoroboron dibenzoylmethane-polylactide, BF 2 dbmPLA, a biocompatible polymerluminophore conjugate was fabricated as nanoparticles. Spherical particles <100 nm in size were generated via nanoprecipitation. Intense blue fluorescence, two-photon absorption, and long-lived room temperature phosphorescence (RTP) are retained in aqueous suspension. The nanoparticles were internalized by cells and visualized by fluorescence microscopy. Luminescent boron biomaterials show potential for imaging and sensing.Keywords boron dye; fluorescence; phosphorescence; poly(lactic acid) (PLA); nanoparticles Difluoroboron-based dyes, such as BODIPY 1 and β-diketonate derivatives, 2 exhibit large extinction coefficients, high emission quantum yields, large two-photon absorption crosssections, and in some cases, sensitivity to the surrounding medium. 3 These exceptional optical properties make them useful as imaging agents, 4 photosensitizers, 5 and sensors. 6 Often dyes are combined with material substrates to modulate properties, enhance stability, and reduce toxicity. Dye leaching with associated toxicity and ambiguity in imaging and sensing schemes can be minimized with dye-polymer conjugates versus blends. 7 For example, active agents such as Ru(II) complexes 8,9 or metalloporphyrins 10 are embedded in polymer matrices that act as protective shells and allow their use in biological contexts with increased stability and improved delivery 11,12 by passive 13,14 or active targeting. 15 Many multifunctional imaging and sensing agents combine controlled material synthesis with nanofabrication. 16,17 Nanoparticles based on luminescent dye conjugates and quantum dots 18 are used to label intracellular structures and pathways in fundamental studies as well as for therapeutic and diagnostic purposes. 19,20 Both fluorescence (singlet) and phosphorescence (triplet) emitters are widely used. Phosphorescence, in particular, is susceptible to oxygen quenching via triplet energy transfer, serving as the basis for oxygen sensing. 21-23 Good oxygen permeability and fast response time are important factors. Photodynamic therapy, on the other hand, utilizes photosensitizers in combination with oxygen or other quenchers to generate reactive species for selective tissue treatment. 24-26Previously we reported that when boron difluoride dibenzoylmethane (BF 2 dbm) is combined with poly(lactic acid) (PLA), a biocompatible polymer, 27 the intense blue fluorescence is retained and new properties emerge, namely temperature-sensitive delayed fluorescence and * Address correspondence to fraser@virginia.edu. NIH Public Access RESULTS AND DISCUSSIONDifluoroboron dibenzoylmethane polylactide, BF 2 dbmPLA (Figure 1), was synthesized by ring opening polymerization of lactide using a hydroxyl-functionalized BF 2 dbm initiator and tin catalyst as previously described. 28 Nanoparticles were produced by the solvent displacement method (i.e., nanoprecipitation) 29,30 in which the polymer is dissolved in a solvent miscible with water (e.g., DMF) (oil phase),...

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Section: Resultsmentioning

confidence: 99%

Boron Polylactide Nanoparticles Exhibiting Fluorescence and Phosphorescence in Aqueous Medium

et al. 2008

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“…The nanoprecipitation technique is a one-step process, also known as the solvent displacement method (Fessi et al, 1989;Dinarvand et al, 2011). Nanoprecipitation is performed using systems containing three basic components, the polymer, the polymer solvent, and the nonsolvent of the polymer (Thioune et al, 1997;Dinarvand et al, 2011).…”

Section: Nanoprecipitation Methodsmentioning

confidence: 99%

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Mirakabad

Nejati-Koshki²,

Akbarzadeh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

406

154

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“…Drug-free and CP-loaded NS, NC, and LNC were prepared by the nanoprecipitation-solvent evaporation technique described by Fessi et al [21], which has been successfully applied to PCL [16,17]. This polymer was chosen because it has been approved by the Food and Drug Administration (FDA) for drug delivery specific applications and has prior been used for nanoparticle preparation [17,[22][23][24].…”

Section: Preparation Of Nanoparticlesmentioning

confidence: 99%

Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects

Mathes

Melero

Conrad

et al. 2016

Journal of Controlled Release

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The treatment of various hair disorders has become a central focus of good dermatologic patient care as it affects men and women all over the world. For many inflammatory-based scalp diseases, glucocorticoids are an essential part of treatment, even though they are known to cause systemic as well as local adverse effects when applied topically. Therefore, efficient targeting and avoidance of these side effects are of utmost importance. Optimizing the balance between drug release, interfollicular permeation, and follicular uptake may allow minimizing these adverse events and simultaneously improve drug delivery, given that one succeeds in targeting a sustained release formulation to the hair follicle. To test this hypothesis, three types of polymeric nanocarriers (nanospheres, nanocapsules, lipid-core nanocapsules) for the potent glucocorticoid Clobetasol propionate (CP) were prepared. They all exhibited a sustained release of drug, as was desired. The particles were formulated as a dispersion and hydrogel and (partially) labeled with Rhodamin B for quantification purposes. Follicular uptake was investigated using the Differential Stripping method and was found highest for nanocapsules in dispersion after application of massage. Moreover, the active ingredient (CP) as well as the nanocarrier (Rhodamin B labeled polymer) recovered in the hair follicle were measured simultaneously, revealing an equivalent uptake of both. In contrast, only negligible amounts of CP could be detected in the hair follicle when applied as free drug in solution or hydrogel, regardless of any massage. Skin permeation experiments using heat-separated human epidermis mounted in Franz Diffusion cells revealed equivalent reduced transdermal permeability for all nanocarriers in comparison to application of the free drug. Combining these results, nanocapsules formulated as an aqueous dispersion and applied by massage appeared to be a good candidate to maximize follicular targeting and minimize drug penetration into the interfollicular epidermis. We conclude that such nanotechnology-based formulations provide a viable strategy for more efficient -2-drug delivery to the hair follicle. Moreover, they present a way to minimize adverse effects of potent glucocorticoids by releasing the drug in a controlled manner and simultaneously decreasing interfollicular permeation, offering an advantage over conventional formulations for inflammatorybased skin/scalp diseases. Graphical Abstract AbbreviationsAA: Alopecia areata ANOVA: Analysis of variance CCT: capric/caprylic triglyceride CP: Clobetasol propionate

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Nanocapsule formation by interfacial polymer deposition following solvent displacement

Cited by 1,950 publications

References 7 publications

Boron Polylactide Nanoparticles Exhibiting Fluorescence and Phosphorescence in Aqueous Medium

Boron Polylactide Nanoparticles Exhibiting Fluorescence and Phosphorescence in Aqueous Medium

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects

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