Nanocargos designed with synthetic and natural polymers for ovarian cancer management

Ps, Sreedharan; Guha, Abhijit; Balasubramanian, Deepika; Udayakumar, Seshachalam; Nag, Moupriya; Lahiri, Dibyajit; Girigoswami, Agnishwar; Girigoswami, Koyeli

doi:10.1007/s00210-023-02608-0

Cited by 11 publications

(3 citation statements)

References 46 publications

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“…Nanoparticles are profoundly used in different fields of biomedicine [21][22][23], targeted drug delivery [24,25], biosensing [26], antimicrobial agents [27,28], imaging [29,30] etc. and special mention is warranted for metal and metal oxide nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of bioinspired silver nanoparticles on zebrafish embryos including a gene expression study

Girigoswami,

Meenakshi

et al. 2024

ADMET DMPK

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Background and purpose: Many sectors use nanoparticles and dispose of them in the aquatic environment without deciding the fate of these particles. Experimental approach: To identify a benign species of nanoparticles which can cause minimum harm to the aquatic environment, a comparative study was done with chemically synthesized silver nanoparticles (AgNPs) and green tea mediated synthesis (GT/AgNP) in both in vitro using human alveolar cancer cell line (A549) and normal cell line (L132), and in in vivo with zebrafish embryos. Key results: The in vitro studies revealed that GT/AgNPs were less toxic to normal cells than cancer cells. The GT/AgNPs showed high biocompatibility for zebrafish embryos monitored microscopically for their developmental stages and by cumulative hatchability studies. The reduced hatchability found in the AgNPs-treated group was correlated by differential gene expression of zebrafish hatching enzymes (ZHE) (ZHE1 and ZHE2). Conclusion: The results indicated that nanoparticles can affect the hatching of zebrafish embryos and elicit toxicity at the gene level. .

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Section: Discussionmentioning

confidence: 99%

Beneficial effects of bioinspired silver nanoparticles on zebrafish embryos including a gene expression study

Girigoswami,

Meenakshi

et al. 2024

ADMET DMPK

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“…To overcome these limitations of conventional cancer treatment strategies, nanomedicines have recently been employed in cancer treatment. Nanotherapeutics overcome the limitations and reduce side effects by their high specificity, biocompatibility, enhanced permeability retention, and increased host immunological response [12]. There are several nanodrug delivery systems available [13,14].…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Role of Nano-Formulated Red Algae Extract in Cancer Management

Janani,

Girigoswami,

Deepika

et al. 2024

Molecules

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Cancer is one of the major causes of death, and its negative impact continues to rise globally. Chemotherapy, which is the most common therapy, has several limitations due to its tremendous side effects. Therefore, developing an alternate therapeutic agent with high biocompatibility is indeed needed. The anti-oxidative effects and bioactivities of several different crude extracts of marine algae have been evaluated both in vitro and in vivo. In the present study, we synthesized the aqueous extract (HA) from the marine algae Amphiroa anceps, and then, a liposome was formulated for that extract (NHA). The extracts were characterized using different photophysical tools like dynamic light scattering, UV–visible spectroscopy, FTIR, scanning electron microscopy, and GC-MS analysis. The SEM image revealed a size range of 112–185 nm for NHA and the GC-MS results showed the presence of octadecanoic acid and n-Hexadecanoic acid in the majority. The anticancer activity was studied using A549 cells, and the NHA inhibited the cancer cells dose-dependently, with the highest killing of 92% at 100 μg/mL. The in vivo studies in the zebrafish model showed that neither the HA nor NHA of Amphiroa anceps showed any teratogenic effect. The outcome of our study showed that NHA can be a potential drug candidate for inhibiting cancer with good biocompatibility up to a dose of 100 μg/mL.

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“…Both nanogels and PNPs have garnered significant attention as carriers for drug delivery and therapeutic applications. Their ease of fabrication and high throughput, along with their biocompatibility and biodegradability, make them promising candidates for various applications, as extensively covered in numerous reviews [ 16 , 17 , 18 ]. However, a key challenge associated with the utilization of PNPs and nanogels arises from protein corona formation when they are dispersed in serum-containing media, such as culture media or blood, for applications in therapy or diagnosis [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Nanoparticles and Nanogels: How Do They Interact with Proteins?

Sadeghi,

PourEskandar,

Askari

et al. 2023

Gels

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Polymeric nanomaterials, nanogels, and solid nanoparticles can be fabricated using single or double emulsion methods. These materials hold great promise for various biomedical applications due to their biocompatibility, biodegradability, and their ability to control interactions with body fluids and cells. Despite the increasing use of nanoparticles in biomedicine and the plethora of publications on the topic, the biological behavior and efficacy of polymeric nanoparticles (PNPs) have not been as extensively studied as those of other nanoparticles. The gap between the potential of PNPs and their applications can mainly be attributed to the incomplete understanding of their biological identity. Under physiological conditions, such as specific temperatures and adequate protein concentrations, PNPs become coated with a “protein corona” (PC), rendering them potent tools for proteomics studies. In this review, we initially investigate the synthesis routes and chemical composition of conventional PNPs to better comprehend how they interact with proteins. Subsequently, we comprehensively explore the effects of material and biological parameters on the interactions between nanoparticles and proteins, encompassing reactions such as hydrophobic bonding and electrostatic interactions. Moreover, we delve into recent advances in PNP-based models that can be applied to nanoproteomics, discussing the new opportunities they offer for the clinical translation of nanoparticles and early prediction of diseases. By addressing these essential aspects, we aim to shed light on the potential of polymeric nanoparticles for biomedical applications and foster further research in this critical area.

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Nanocargos designed with synthetic and natural polymers for ovarian cancer management

Cited by 11 publications

References 46 publications

Beneficial effects of bioinspired silver nanoparticles on zebrafish embryos including a gene expression study

Beneficial effects of bioinspired silver nanoparticles on zebrafish embryos including a gene expression study

Unveiling the Role of Nano-Formulated Red Algae Extract in Cancer Management

Polymeric Nanoparticles and Nanogels: How Do They Interact with Proteins?

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