Nanocarriers for drug delivery to the inner ear: Physicochemical key parameters, biodistribution, safety and efficacy

Jaudoin, Céline; Agnely, Florence; Nguyen, Yann; Ferrary, Évelyne; Bochot, Amélie

doi:10.1016/j.ijpharm.2020.120038

Cited by 28 publications

(25 citation statements)

References 180 publications

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“…Inner ear infections are challenging to treat due to their isolated location. Placed in the temporal bone, the inner ear is protected by many anatomical and physiological barriers, which hinder therapeutics’ delivery ( Figure 2 ) [ 14 , 51 , 52 , 53 , 54 , 55 , 56 ].…”

Section: Administration Routesmentioning

confidence: 99%

“…This technique significantly increases drug bioavailability in the inner ear, having the highest efficiency among all administration possibilities [ 61 ]. Nonetheless, this is a highly invasive approach, requiring surgical intervention [ 51 ].…”

Section: Administration Routesmentioning

confidence: 99%

“…SPIONs cannot encapsulate any substance, but they can be loaded into polymeric nanoparticles or coated with the needed drug. For inner ear drug delivery, SPIONs have been tested in combination with PLGA, chitosan, silica, and dextran [ 13 , 51 , 56 ]. Such nanocomposites can significantly enhance antibiotics’ activity against both Gram-positive and Gram-negative bacteria, being a helpful tool in treating multi-drug resistant pathogen strains infections [ 99 , 100 , 101 ].…”

Section: Nanoparticles-mediated Treatmentmentioning

confidence: 99%

“…Abbreviations: BLB—blood-labyrinth barrier, RW—round window, OW—oval window. Created based on information from literature References [ 14 , 51 , 54 , 56 , 75 ].…”

Section: Figurementioning

confidence: 99%

“… Schematic representation of various nanoparticles: ( a ) liposome; ( b ) lipid core nanoparticle; ( c ) ceramic nanoparticle; ( d ) polymeric nanoparticle; ( e ) superparamagnetic iron oxide NP (SPION)-loaded polymeric nanoparticle; ( f ) coated SPION. Created based on information from literature References [ 11 , 12 , 13 , 51 , 83 , 84 , 85 ]. …”

Section: Figurementioning

confidence: 99%

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Nanoparticles for the Treatment of Inner Ear Infections

et al. 2021

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The inner ear is sensitive to various infections of viral, bacterial, or fungal origin, which, if left untreated, may lead to hearing loss or progress through the temporal bone and cause intracranial infectious complications. Due to its isolated location, the inner ear is difficult to treat, imposing an acute need for improving current therapeutic approaches. A solution for enhancing antimicrobial treatment performance is the use of nanoparticles. Different inorganic, lipidic, and polymeric-based such particles have been designed, tested, and proven successful in the controlled delivery of medication, improving drug internalization by the targeted cells while reducing the systemic side effects. This paper makes a general presentation of common inner ear infections and therapeutics administration routes, further focusing on newly developed nanoparticle-mediated treatments.

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Section: Administration Routesmentioning

confidence: 99%

Section: Administration Routesmentioning

confidence: 99%

Section: Nanoparticles-mediated Treatmentmentioning

confidence: 99%

“…Abbreviations: BLB—blood-labyrinth barrier, RW—round window, OW—oval window. Created based on information from literature References [ 14 , 51 , 54 , 56 , 75 ].…”

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Nanoparticles for the Treatment of Inner Ear Infections

et al. 2021

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Cutting‐Edge Achievements of Inner Ear Drug Delivery Systems

Zhang,

Xu,

Wang

et al. 2024

Advanced NanoBiomed Research

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The intricate physiological structure of the inner ear presents challenges for traditional medication treatment strategies, including systemic adverse responses, trouble penetrating the blood–labyrinth barrier, and low local cochlear concentration, resulting in poor therapeutic outcomes. An intriguing tactic that is extensively developed over decades is utilizing drug delivery systems to transport medication molecules to the inner ear. Herein, the challenges associated with inner ear delivery are discussed, cutting‐edge achievements in inner ear drug delivery systems are emphasized, including nano‐, micro‐, and macrocarriers, and finally opportunities to leverage advanced technologies to improve existing drug delivery strategies are highlighted.

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Magnetic/Acoustic Dual‐Controlled Microrobot Overcoming Oto‐Biological Barrier for On‐Demand Multidrug Delivery against Hearing Loss

Yi,

Guo,

Zeng

et al. 2024

Small

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Multidrug combination therapy in the inner ear faces diverse challenges due to the distinct physicochemical properties of drugs and the difficulties of overcoming the oto‐biologic barrier. Although nanomedicine platforms offer potential solutions to multidrug delivery, the access of drugs to the inner ear remains limited. Micro/nanomachines, capable of delivering cargo actively, are promising tools for overcoming bio‐barriers. Herein, a novel microrobot‐based strategy to penetrate the round window membrane (RWM) is presented and multidrug in on‐demand manner is delivered. The tube‐type microrobot (TTMR) is constructed using the template‐assisted layer‐by‐layer (LbL) assembly of chitosan/ferroferric oxide/silicon dioxide (CS/Fe3O4/SiO2) and loaded with anti‐ototoxic drugs (curcumin, CUR and tanshinone IIA, TSA) and perfluorohexane (PFH). Fe3O4 provides magnetic actuation, while PFH ensures acoustic propulsion. Upon ultrasound stimulation, the vaporization of PFH enables a microshotgun‐like behavior, propelling the drugs through barriers and driving them into the inner ear. Notably, the proportion of drugs entering the inner ear can be precisely controlled by varying the feeding ratios. Furthermore, in vivo studies demonstrate that the drug‐loaded microrobot exhibits superior protective effects and excellent biosafety toward cisplatin (CDDP)‐induced hearing loss. Overall, the microrobot‐based strategy provides a promising direction for on‐demand multidrug delivery for ear diseases.

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Nanocarriers for drug delivery to the inner ear: Physicochemical key parameters, biodistribution, safety and efficacy

Cited by 28 publications

References 180 publications

Nanoparticles for the Treatment of Inner Ear Infections

Nanoparticles for the Treatment of Inner Ear Infections

Cutting‐Edge Achievements of Inner Ear Drug Delivery Systems

Magnetic/Acoustic Dual‐Controlled Microrobot Overcoming Oto‐Biological Barrier for On‐Demand Multidrug Delivery against Hearing Loss

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