Nanoparticles for the Treatment of Inner Ear Infections

Gheorghe, Dan Cristian; Niculescu, Adelina-Gabriela; Bîrcă, Alexandra Cătălina; Grumezescu, Alexandru Mihai

doi:10.3390/nano11051311

Cited by 20 publications

(14 citation statements)

References 139 publications

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“…Polymer nanoparticles are also useful for delivering drugs to hard-to-reach tissues and organs. For instance, they can facilitate drug permeation to challenging anatomic structures, such as the inner ear [241][242][243][244], retina [245][246][247][248][249], brain [250][251][252][253][254], and avascular connective tissues [255][256][257].…”

Section: Drug Deliverymentioning

confidence: 99%

Polymer-Based Nanosystems—A Versatile Delivery Approach

Niculescu

Grumezescu

2021

Materials

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Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting the payload from degradation and maintaining sustained and controlled release of the drug, polymeric nanoparticles can reduce drug clearance, increase their cargo’s stability and solubility, prolong its half-life, and ensure optimal concentration at the target site. The inherent immunomodulatory properties of specific polymer nanoparticles, coupled with their drug encapsulation ability, have raised particular interest in vaccine delivery. This paper aims to review current and emerging drug delivery applications of both branched and linear, natural, and synthetic polymer nanostructures, focusing on their role in vaccine development.

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Section: Drug Deliverymentioning

confidence: 99%

Polymer-Based Nanosystems—A Versatile Delivery Approach

Niculescu

Grumezescu

2021

Materials

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“…Delivery systems, including systemic drug delivery, intratympanic injection, hydrogel drug delivery, and nanocarrier drug delivery systems, have been used for inner ear disease therapy (Li et al, 2017 ; Kayyali et al, 2018 ; Hao and Li, 2019 ; Mittal et al, 2019 ; Rathnam et al, 2019 ; Gheorghe et al, 2021 ; Jaudoin et al, 2021 ). Among all current inner ear therapies, the intratympanic injection of liquid drugs is most widely used.…”

Section: Current Drug Delivery Systems For Inner Ear Disease Therapymentioning

confidence: 99%

Nanocarriers for Inner Ear Disease Therapy

Zheng

et al. 2021

Front. Cell. Neurosci.

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Hearing loss is a common disease due to sensory loss caused by the diseases in the inner ear. The development of delivery systems for inner ear disease therapy is important to achieve high efficiency and reduce side effects. Currently, traditional drug delivery systems exhibit the potential to be used for inner ear disease therapy, but there are still some drawbacks. As nanotechnology is developing these years, one of the solutions is to develop nanoparticle-based delivery systems for inner ear disease therapy. Various nanoparticles, such as soft material and inorganic-based nanoparticles, have been designed, tested, and showed controlled delivery of drugs, improved targeting property to specific cells, and reduced systemic side effects. In this review, we summarized recent progress in nanocarriers for inner ear disease therapy. This review provides useful information on developing promising nanocarriers for the efficient treatment of inner ear diseases and for further clinical applications for inner ear disease therapy.

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“…In the past few decades, several NPs with particle size of 100 nm to 1μm have been employed as carriers for treating and or preventing various disorders with better results. 25,32,[41][42][43][44][45][46][47][48][33][34][35][36][37][38][39][40] Nanoparticles (NPs) have been proved to avoid poor solubility, distribution stability, permeability and off target cell activity of pharmacotherapies, rapid drug clearance from inner ear cavity, these are precondition for achieving therapeutic amount of drug in the target site of the inner ear and effective pharmaceutical treatments for otic diseases in preclinical level. Because of these advantages, biocompatible NPs have been involved in otology imaging.…”

Section: Introductionmentioning

confidence: 99%

An Overview of Nanoparticle Drug Delivery for Ototoxin and Noise Mediated Hearing Loss Treatment

Sreeharsha¹,

Nataraj²,

Jang³

et al. 2022

Ind. J. Pharm. Edu. Res

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Efficient delivery of therapeutic material to target site of the inner ear is considered as the most challenging process due to their poor blood flow and inaccessibility sensitivity towards chemical stimuli, inability of drug to be delivered as well. Novel nanoparticlebased drug transport approaches have emerged for overcoming the restriction associated with inner ear therapeutic material delivery. The main focus of this article is to highlight the potential benefits, pre-clinical level otoprotective effect of different types of NPs based payload delivery strategies in mitigating sensorineural hearing impairment resulting from medication (cisplatin and antibiotic treatment) and noise exposure. This review converses about advantage of nanocarrier assisted targeted cell specific inner ear drug delivery approach and demonstrates that targeted NPs delivery systems have the capability to be utilized as vehicle to transport therapeutic materials into the OHCs within the cochlea in controlled and sustained way and maximize following therapeutic effects. Efficacy of systemic and minimally invasive intratympanic and RWM approach for delivering steroids/ genetic material to the inner ear has also been compared in this article. Understanding the importance (design, formulation, cochlear biocompatibility and cell specific binding efficiency of NPs, mechanistic pathways, route of delivery, positive therapeutic outcomes) and hitches (adverse effects after treatment, negative therapeutic outcome) of currently available NPs based drug delivery systems offer new opportunity to develop best treatment methods for sensorineural hearing dysfunction.

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Nanoparticles for the Treatment of Inner Ear Infections

Cited by 20 publications

References 139 publications

Polymer-Based Nanosystems—A Versatile Delivery Approach

Polymer-Based Nanosystems—A Versatile Delivery Approach

Nanocarriers for Inner Ear Disease Therapy

An Overview of Nanoparticle Drug Delivery for Ototoxin and Noise Mediated Hearing Loss Treatment

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