Nanocellulose/bioactive glass cryogels as scaffolds for bone regeneration

Abstract

Cellulose nanofibrils and bioactive glass are assembled into a porous network and used as scaffold for bone regeneration. The obtained organic–inorganic composite material optimally combine the necessary features for in vivo bone repair.

Surface functionalization of bioactive glasses and hydroxyapatite with polyphenols from organic red grape pomace

“…The high resolution spectrum of the oxygen region for B+P (Figure 7o) was similar to the one of the freeze-dried extract (Figure 7b): three signals can be observed at 531.26 eV, 532.57 eV and 533.39 eV and associated to C-O, O=C-OH and aromatic OH (36), (37). Finally, the high resolution of the calcium region (Figure 7p) has two signals at 347.12 eV and 350.72 eV, which are connected to the Ca-O bonds (45).…”

In Vivo Behavior of Bioactive Glass-Based Hybrids in Animal Models For Bone Regeneration

“…Eucalyptus grandis cellulose nanofibrils and particulate Bioglass® 45S5, can be obtained through a freezecasting route. Using a Wistar rat calvarial defect model, Bioglass®-reinforced cryogels significantly improved bone formation, at 8 weeks post-implantation, compared to cryogels of pure cellulose nanofibrils [39].…”

Processing-structure-property relationships of electrospun PLA-PEO membranes reinforced with enzymatic cellulose nanofibers

“…In recent years, the development of bionanocomposites has attracted both industrial and academic attention because of increasing interest on developing new sustainable and ecofriendly materials, in the perspective of preventing the accumulation of plastics waste [1][2][3]. One of the most promising and widespread biopolymers is polylactic acid (PLA), which presents many advantages such as renewability, compostability, biocompatibility, high transparency, availability in the market, excellent tensile strength and stiffness equivalent to some commercial oil-based polymers [4][5][6][7][8][9][10]. PLA is a linear aliphatic thermoplastic polyester derived from 100% renewable resources such as sugar, corn, potatoes, cane, beet, etc.…”

“…that presents a fragile behavior with relatively high elastic modulus and low elongation at break [6,7]. Nevertheless, there are some disadvantages, such as its high brittleness, slow crystallization behavior, poor biodegradability and low gas barrier properties that may limit its current use in some application fields [9][10][11][12][13][14]. Among the strategies to improve PLA toughness, adding a second polymer as a plasticizer, such as polyethylene glycol (PEG) or polyethylene oxide (PEO), is suitable.…”