Nanoceria: A rare-earth nanoparticle as a promising anti-cancer therapeutic agent in colon cancer

Panda, Smita Rani; Singh, Rohit Kumar; Priyadarshini, B.; Rath, Pragyan Parimita; Parhi, Pankaj Kumar; Sahoo, Trilochan; Mandal, Dindyal; Sahoo, Tapas Ranjan

doi:10.1016/j.mssp.2019.104669

Cited by 14 publications

(7 citation statements)

References 45 publications

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“…During this decrease, insulin solubility is reduced and precipitates within the crystal pores. At these lower pHs, CaCO 3 also undergoes dissolution and pure insulin particles are formed (Figure 9(1)) [122,177]. Polyelectrolytes may also be deposited upon protein particles via LbL to control release, as with α-chymotrypsin for instance [178,179].…”

Section: Beads Formed From Porous Templatesmentioning

confidence: 99%

“…BSA and goat anti-human immunoglobulin G were co-synthesised into CaCO 3 crystals, reaching loading efficiencies of up to 70%, followed by cross-linking with glutaraldehyde and dissolution with EDTA. Due to hydrophobic effects, the final porous protein particles shrank by 31% of the original crystal size, similarly to that of other protein-based particles [122,182]. With increasing control over the original porous template size (e.g., CaCO 3 , both with [170] and without [123] additives, MnCO 3 [188], and mesoporous silica [189]), one may exert fine control over the final polymer particle size.…”

Section: Beads Formed From Porous Templatesmentioning

confidence: 99%

“…Furthermore, bismuth enabled highcontrast CT imaging [121]. Ceria NPs have also been proposed for the treatment of colon cancer, as it was noted that they can exert higher cytotoxicity in cancer cells relative to healthy cells through the generation of ROS and subsequent triggering of apoptosis [122]. In pancreatic cancer cells, ceria NPs acted as sensitizers to radiation therapy through activation of c-Jun kinase that promoted apoptosis, whilst protecting normal tissues from radiotherapy adverse effects [123].…”

Section: Ros Mitigation For the Treatment Of Cancer And Chemotherapy'...mentioning

confidence: 99%

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Design of Micro- and Nanoparticles: Self-Assembly and Application

2022

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Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Preface to "Design of Micro-and Nanoparticles: Self-Assembly and Application"Micro-/nanoparticles (M&NPs) have attracted researchers'interest due to their unique chemical and physical properties. Recent advances in the synthesis of M&NPs (metallic, metal oxide, silica, polymeric, lipid-based, supramolecular, colloidal, and carbon-based M&NPs) have offered exciting opportunities for many applications, such as catalysis, plasmonics, sensors, magnetism, drug delivery, and nanomedicine. The use of self-assembly for the synthesis or modification of M&NPs provides unlimited possibilities for designing nanomaterials with desired properties. This reprint presents the most recent developments in the synthesis, modification, properties, and applications of M&NPs. This book will be useful to scientists of diverse backgrounds, i.e., material science, organic and inorganic chemistry, biochemistry, and biology.

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Section: Beads Formed From Porous Templatesmentioning

confidence: 99%

Section: Beads Formed From Porous Templatesmentioning

confidence: 99%

Section: Ros Mitigation For the Treatment Of Cancer And Chemotherapy'...mentioning

confidence: 99%

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Design of Micro- and Nanoparticles: Self-Assembly and Application

2022

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“…Furthermore, bismuth enabled high-contrast CT imaging [ 121 ]. Ceria NPs have also been proposed for the treatment of colon cancer, as it was noted that they can exert higher cytotoxicity in cancer cells relative to healthy cells through the generation of ROS and subsequent triggering of apoptosis [ 122 ]. In pancreatic cancer cells, ceria NPs acted as sensitizers to radiation therapy through activation of c–Jun kinase that promoted apoptosis, whilst protecting normal tissues from radiotherapy adverse effects [ 123 ].…”

Section: (Bio)applicationsmentioning

confidence: 99%

Nanostructured Ceria: Biomolecular Templates and (Bio)applications

et al. 2021

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Ceria (CeO2) nanostructures are well-known in catalysis for energy and environmental preservation and remediation. Recently, they have also been gaining momentum for biological applications in virtue of their unique redox properties that make them antioxidant or pro-oxidant, depending on the experimental conditions and ceria nanomorphology. In particular, interest has grown in the use of biotemplates to exert control over ceria morphology and reactivity. However, only a handful of reports exist on the use of specific biomolecules to template ceria nucleation and growth into defined nanostructures. This review focusses on the latest advancements in the area of biomolecular templates for ceria nanostructures and existing opportunities for their (bio)applications.

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“…CeO 2 nanoparticles have highly reactive surface area due to presence of oxygen vacancies in their structures, acting as free radical scavengers [2], and they are useful for several applications, such as, biomedical [3,4], biological [5], gas sensing [6], catalysis [7], energy production [8] and optical devices [9]. Nanoceria can be synthetized following several methods [3][4][5]10,11], i.e., by precipitation [12], green synthesis [13], hydrothermal [14,15], solvothermal [16], microwave-assisted [17,18] and sonochemical [19]…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Solvothermal Synthesis of Fe3O4/CeO2 Nanocomposites and Their Catalytic Activity in the Imine Formation from Benzyl Alcohol and Aniline

et al. 2020

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Fe3O4/CeO2 nanocomposites were synthetized by coating magnetite seeds of different morphologies (hexagonal, spheroidal, quasi-spherical) with ceria, in ethylene glycol as solvothermal solvent. The synthesis was performed in the presence of microwave irradiation aiming to overcome the common disadvantages proper of the classic solvothermal/hydrothermal procedure. The obtained nanocomposites were calcined at the optimum temperature of 550 °C. The structure of the new nanomaterials was carefully investigated by IR, XRD, SEM, EDS and TEM analyses. The nanocomposites resulted to be constituted by CeO2 nanoparticles distributed onto Fe3O4 seeds, that kept their pristine morphology. The new materials were used as catalysts for imine synthesis from benzyl alcohol and aniline. The highest imine conversion rate was obtained with Fe3O4/CeO2, which was synthesized from Fe3O4 nanoparticles (hexagonal) obtained by microwave hydrothermal procedure in the absence of any organic additive (polyvinylpyrrolidone, trisodium citrate dihydrate or oleic acid). The catalyst could be easily removed from the reaction mixture with the help of an external magnet, and it was recycled for at least five runs with increasing catalytic activity.

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Nanoceria: A rare-earth nanoparticle as a promising anti-cancer therapeutic agent in colon cancer

Cited by 14 publications

References 45 publications

Design of Micro- and Nanoparticles: Self-Assembly and Application

Design of Micro- and Nanoparticles: Self-Assembly and Application

Nanostructured Ceria: Biomolecular Templates and (Bio)applications

Microwave-Assisted Solvothermal Synthesis of Fe3O4/CeO2 Nanocomposites and Their Catalytic Activity in the Imine Formation from Benzyl Alcohol and Aniline

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