2014
DOI: 10.2147/ijn.s66876
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Nanocomplexes of an insulinotropic drug: optimization, microparticle formation, and antidiabetic activity in rats

Abstract: The aim of the present work was to test the ability of two non-diabetogenic carbohydrates to intranasally deliver the insulinotropic drug repaglinide (REP) for controlling blood glucose level. REP was loaded onto chitosan/alginate nanocomplexes (NCs) suitable for mucosal delivery and uptake. Improved stability and delivery characteristics were obtained by spray drying the selected NCs, yielding microparticles. A statistical experimental design was adopted to investigate the effects of the formulations’ variabl… Show more

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