Nanocomposite antimicrobials prevent bacterial growth through the enzyme-like activity of Bi-doped cerium dioxide (Ce1−xBixO2−δ)

Frerichs, Hajo; Pütz, Eva; Pfitzner, Felix; Reich, Tobias; Gazanis, Athanasios; Panthöfer, Martin; Hartmann, Jens; Jegel, Olga; Heermann, Ralf; Tremel, Wolfgang

doi:10.1039/d0nr06165d

Cited by 26 publications

(20 citation statements)

References 93 publications

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“…The hydrothermal oxidation of Ce 3+ in basic aqueous solution by NaBiO 3 at 240 • C provides a redox synthetic method, where the product phase contains Ce 4+ and Bi 3+ , to form nanocrystalline powders (Figure 11) that show high reducibility, although the extrusion of the Bi metal will limit the practical application of the materials [94]. Bisubstituted CeO 2 has frequently been investigated for use in photocatalysis, although it has also been looked at for uses such as antibacterial activity: Frerichs et al produced single, cubic-phase samples up to 20 mol% Bi by reacting Bi and Ce nitrates in NaOH and heating to 80 • C for 25 h [95]. Samples made using a higher level of Bi were a two-phase mix of the cubic CeO 2 structure and the monoclinic Bi 2 O 3 material.…”

Section: Main Group Substituentsmentioning

confidence: 99%

Solvothermal Synthesis Routes to Substituted Cerium Dioxide Materials

et al. 2021

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We review the solution-based synthesis routes to cerium oxide materials where one or more elements are included in place of a proportion of the cerium, i.e., substitution of cerium is performed. The focus is on the solvothermal method, where reagents are heated above the boiling point of the solvent to induce crystallisation directly from the solution. This yields unusual compositions with crystal morphology often on the nanoscale. Chemical elements from all parts of the periodic table are considered, from transition metals to main group elements and the rare earths, including isovalent and aliovalent cations, and surveyed using the literature published in the past ten years. We illustrate the versatility of this synthesis method to allow the formation of functional materials with applications in contemporary applications such as heterogeneous catalysis, electrodes for solid oxide fuel cells, photocatalysis, luminescence and biomedicine. We pick out emerging trends towards control of crystal habit by use of non-aqueous solvents and solution additives and identify challenges still remaining, including in detailed structural characterisation, the understanding of crystallisation mechanisms and the scale-up of synthesis.

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Section: Main Group Substituentsmentioning

confidence: 99%

Solvothermal Synthesis Routes to Substituted Cerium Dioxide Materials

et al. 2021

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“…Vanadium haloperoxidases are generally secreted by the algae Corallina officinalis and Delisea pulchra [15]. Haloperoxidase is a special peroxidase, which can mediate H 2 O 2 to oxidize halide X − to OX − [16]. Since the chromogenic substrate is phenol red and the brominated product is bromophenol blue, both of which have obvious color changes, the haloperoxidase mimics are particularly suitable for ratiometric colorimetric sensing.…”

Section: Introductionmentioning

confidence: 99%

Ce-MOF with Intrinsic Haloperoxidase-Like Activity for Ratiometric Colorimetric Detection of Hydrogen Peroxide

Cheng

Liang

et al. 2021

Biosensors

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Metal–organic framework (MOF) nanozymes, as emerging members of the nanozymes, have received more and more attention due to their composition and structural characteristics. In this work, we report that mixed-valence state Ce-MOF (MVCM) has intrinsic haloperoxidase-mimicking activity. MVCM was synthesized by partial oxidation method using Ce-MOF as a precursor. In the presence of H2O2 and Br−, MVCM can catalyze oxidative bromination of chromogenic substrate phenol red (PR) to produce the blue product bromophenol blue (Br4PR), showing good haloperoxidase-like activity. Because of the special chromogenic substrate, we constructed a ratiometric colorimetric-sensing platform by detecting the absorbance of the MVCM-(PR, Br−) system at wavelengths of 590 and 430, for quantifying H2O2, where the detection limit of the H2O2 is 3.25 μM. In addition, the haloperoxidase-mimicking mechanism of the MVCM is proposed. Moreover, through enzyme kinetics monitoring, the Km (H2O2 and NH4Br) of the MVCM is lower than that of cerium oxide nanomaterials, indicating that the MVCM has a stronger binding affinity for H2O2 and NH4Br than other materials. This work provides more application prospects for the development of nanozymes in the field of biosensors in the future.

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“…In particular, a bioinspired strategy was used, since marine organisms rely on biohalogenation as a defense strategy against bacterial colonization, since it interferes with bacterial communication. Bismuth substitution enhanced the enzyme-like activity of ceria NPs three-fold, and the incorporation of the nanosystem into polyethersulfone beads, which are typical constituents of water filter membrane supports, led to decreased adhesion of the Gram-negative soil bacterium Pseudomonas aeruginosa and of Phaeobacter gallaeciensis , a primary bacterial colonizer in marine biofilms [ 187 ].…”

Section: (Bio)applicationsmentioning

confidence: 99%

Nanostructured Ceria: Biomolecular Templates and (Bio)applications

et al. 2021

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Ceria (CeO2) nanostructures are well-known in catalysis for energy and environmental preservation and remediation. Recently, they have also been gaining momentum for biological applications in virtue of their unique redox properties that make them antioxidant or pro-oxidant, depending on the experimental conditions and ceria nanomorphology. In particular, interest has grown in the use of biotemplates to exert control over ceria morphology and reactivity. However, only a handful of reports exist on the use of specific biomolecules to template ceria nucleation and growth into defined nanostructures. This review focusses on the latest advancements in the area of biomolecular templates for ceria nanostructures and existing opportunities for their (bio)applications.

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Nanocomposite antimicrobials prevent bacterial growth through the enzyme-like activity of Bi-doped cerium dioxide (Ce_1−xBi_xO_2−δ)

Abstract: Preventing bacterial adhesion on materials surfaces is an important problem in marine, industrial, medical and environmental fields and a topic of major medical and societal importance. A defense strategy of...

Cited by 26 publications

References 93 publications

Solvothermal Synthesis Routes to Substituted Cerium Dioxide Materials

Solvothermal Synthesis Routes to Substituted Cerium Dioxide Materials

Ce-MOF with Intrinsic Haloperoxidase-Like Activity for Ratiometric Colorimetric Detection of Hydrogen Peroxide

Nanostructured Ceria: Biomolecular Templates and (Bio)applications

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