Nanocomposite-Coated Sterile Cotton Gas Based on Polylactic Acid and Nanoparticles (Zinc Oxide and Copper Oxide) and Tranexamic Acid Drug with the Aim of Wound Dressing

Rashedi, Samira Molapour; Khajavi, Ramin; Rashidi, Abosaeed; Rahimi, Mohammad; Bahador, Abbas

doi:10.1007/s40883-021-00203-4

Cited by 9 publications

(1 citation statement)

References 42 publications

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“…In other studies, wound dressings fabricated through an electrospinning process incorporated graphene oxide (GO) into a PLA solution at concentrations of up to 1% to enhance hydrophilicity or used quercetin (Q) to enable rapid and complete release under external electrical stimulation within just 1-2 min [43]. Some compositions included 1% CuO and ZnO NPs/2% tranexamic acid (TXA) to improve hydrophilicity [44] or 1% babassu oil to maintain a humid environment around the wound [45]. The reported tensile strength of human skin falls within the range of 1 to 40 Mpa.…”

Section: Fabrication Of the Dual-layer Nanofiber Biomaterialsmentioning

confidence: 99%

Conversion of Animal-Derived Protein By-Products into a New Dual-Layer Nanofiber Biomaterial by Electrospinning Process

Gaidău,

Râpă,

Stefan

et al. 2023

Fibers

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The aim of this study was to design a dual-layer wound dressing as a new fibrous biomaterial based on the valorization of animal-derived proteins. The first layer was fabricated by the deposition of poly(ethylene oxide) (PEO) loaded with keratin hydrolysate (KH) via a mono-electrospinning process onto a poly(lactic acid) (PLA) film, which was used as a support. The second layer consisted of encapsulating a bovine collagen hydrolysate (CH) into poly(vinyl pyrrolidone) (PVP) through a coaxial electrospinning process, which was added onto the previous layer. This assemblage was characterized by electronic microscopy for morphology and the controlled release of KH. In vitro biocompatibility was evaluated on the L929 (NCTC) murine fibroblasts using quantitative MTT assay and qualitative cell morphological examination after Giemsa staining. Additionally, in vivo biocompatibility methods were used to assess the impact of the biomaterial on white Swiss mice, including the evaluation of hematological, biochemical, and immunological profiles, as well as its impact on oxidative stress. The results revealed a nanofibrous structure for each layer, and the assembled product demonstrated antioxidant activity, controlled release of KH, a high degree of in vitro biocompatibility, negligible hematological and biochemical changes, and minimal impact of certain specific oxidative stress parameters compared to the use of patches with textile support.

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Section: Fabrication Of the Dual-layer Nanofiber Biomaterialsmentioning

confidence: 99%

Conversion of Animal-Derived Protein By-Products into a New Dual-Layer Nanofiber Biomaterial by Electrospinning Process

Gaidău,

Râpă,

Stefan

et al. 2023

Fibers

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Combination of polylactide with cellulose for biomedical applications: a recent overview

Kopańska,

Brzeziński,

Draczyński

2023

Cellulose

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This review summarizes the use of cellulose and polylactide for medical applications with particular emphasis on modern dressings. Although classic cotton and viscose dressings are still available and popular, the usefulness of new forms of cellulose (Cel) and its derivatives opens new wound treatment options. Therefore, trends in functionalizing traditional cellulose dressings, including products made of bacterial cellulose, and dressings from cellulose derivatives, are discussed. Polylactide (PLA), in turn, is a biodegradable and biocompatible polyester that fulfills plenty of tasks in many medical fields, from surgery to modern diagnostic methods. However, polylactide dressings can still be advantageous to the market. Thus, the next part of the article contains a recent update of available knowledge about PLA and its applications in regenerative medicine and drug-delivery systems. The last part is devoted to the possibilities of combining both materials in dressings and related problems and benefits. Methods for compatibilization with the surface of both polymers and new techniques for producing Cel/PLA composite materials are also described.

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Polymers in wound dressing

Râpă,

Darie-Niță

2024

Polymeric Materials for Biomedical Implants

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Nanocomposite-Coated Sterile Cotton Gas Based on Polylactic Acid and Nanoparticles (Zinc Oxide and Copper Oxide) and Tranexamic Acid Drug with the Aim of Wound Dressing

Cited by 9 publications

References 42 publications

Conversion of Animal-Derived Protein By-Products into a New Dual-Layer Nanofiber Biomaterial by Electrospinning Process

Conversion of Animal-Derived Protein By-Products into a New Dual-Layer Nanofiber Biomaterial by Electrospinning Process

Combination of polylactide with cellulose for biomedical applications: a recent overview

Polymers in wound dressing

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