Nanocomposite scaffolds of bioactive glass ceramic nanoparticles disseminated chitosan matrix for tissue engineering applications

Peter, Mathew; Sathy, Binulal N.; Sheela, S.; Nair, Shanti V.; Furuike, Tetsuya; Tamura, Hiroshi; Jayakumar, R.

doi:10.1016/j.carbpol.2009.08.001

Cited by 182 publications

(109 citation statements)

References 31 publications

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“…These peaks were also verified in the spectrum of the sample AcP after contact with SBF, indicating that the silicate coating is still present on the ABS substrate. New peaks appeared at 3360 and 1653 cm -1 , related to water vibrations, and at 610 and 550 cm -1 , ascribed to the P-O vibration [72], thereby corroborating the observations from the X-ray analysis and evidencing formation of the calcium phosphate silicate. The FTIR-ATR spectrum recorded for the sample AsP after contact with SBF displayed peaks characteristic of crystalline phosphate at 600 and 560 cm -1 , and carbonate hydroxyapatite, at 1451, 1408, and 874 cm -1 [72].…”

Section: Preparation Of Biomaterials By the Hydrolytic Sol-gel Processsupporting

confidence: 85%

Biomaterials and Sol–Gel Process: A Methodology for the Preparation of Functional Materials

Nassar¹,

Ciuffi²,

Calefi³

et al. 2011

Biomaterials Science and Engineering

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Section: Preparation Of Biomaterials By the Hydrolytic Sol-gel Processsupporting

confidence: 85%

Biomaterials and Sol–Gel Process: A Methodology for the Preparation of Functional Materials

Nassar¹,

Ciuffi²,

Calefi³

et al. 2011

Biomaterials Science and Engineering

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“…Table 2 describes the main vibration modes observed for the samples and their attribution. 30 The latter peaks corroborated the X-ray analysis data and indicated formation of calcium phosphate silicate. The FTIR-ATR spectrum of the sample AsP after contact with SBF displayed peaks characteristic of hydroxyapatite at 1451, 1408, and 874 cm -1 .…”

Section: X-ray Diffractionsupporting

confidence: 68%

Calcium Phosphate Coatings by Sol-Gel on Acrylonitrile-butadiene-styrene Substrate

Bandeira¹,

Campos²,

Ciuffi³

et al. 2016

J. Braz. Chem. Soc.

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Additive manufacture is an effective technology to produce complex macrostructures from polymers. Sol-gel is a chemical process that affords multifunctional materials by functionalization of different substrates. This work reports on the use of acrylonitrile-butadiene-styrene polymer (ABS) as starting material to obtain a substrate by additive manufacture. Coating of ABS by the sol-gel methodology generated a multifunctional material. Sols with and without phosphate ions were prepared from silicon and calcium alkoxide. Based on X-ray diffraction patterns, a calcium phosphate crystalline structure emerged on ABS after contact of the substrate with simulated body fluid. Infrared analysis revealed that the peaks of the functionalized substrate shifted, indicating that ABS interacted with the sol-gel coating. According to thermal analysis, the maximum decomposition temperature of the coated samples was 20 °C higher as compared to non-coated ABS. Sol-gel and additive manufacture are important technologies to produce materials with applications in biological medium. Keywords: dip-coating, sol-gel, biomaterials IntroductionAdditive manufacture (AM, also known as rapid prototyping) assembles materials in the powder, filament, liquid, or slide form. The materials consist of successively stacked thin layers, resulting in a three-dimensional structure.AM uses computer-aided design (CAD) software to build a mould for the scaffold. The mould displays a branching network of shafts that will define the microchannels in the scaffold.1-5 The fusion deposition model (FDM) technique helps to structure the acrylonitrilebutadiene-styrene polymer (ABS), a mobile extruder head deposits layers of molten material. The layer-by-layer building approach produces highly complex structures that would be impossible to achieve with technologies based on material subtraction, the most frequently employed procedure nowadays. AM has important applications in several areas, including the aircraft and automobile industries, telecommunications, and medicine. [6][7][8] The sol-gel route is a chemical process that involves formation of a sol, namely a colloidal suspension of particles or molecules with liquid character and measuring between 1 and 1000 nm. The sol later goes through a gel phase, which consists of a colloidal system with solid character. In the gel phase, the molecules form a dispersed, continuous, branched, and interpenetrated structure in a system that is usually liquid. After solvent evaporation, the gel phase becomes a solid material that can be either a xerogel, if the solvent is removed by simple evaporation, or an aerogel, if the solvent is removed above its critical temperature and pressure. 9-12The sol-gel process is widely employed to prepare glasses and oxides and to modify surfaces. Sol-gel encompasses hydrolysis and condensation of metal alkoxides or semi-metallic precursors under mild conditions, to generate a polymer network. [13][14][15][16][17][18][19] Alkoxides can form homogeneous sols in various solvents and in the p...

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“…Extract in the form of leachables from the developed scaffolds were obtained according to the methods of Peter et al (2010). Scaffolds sterilized through autoclaving and UV irradiation for 20 minutes were incubated in 20 mL of DMEM culture media in separate flasks at 37°C for 24 hours in order to obtain the scaffold extracts.…”

Section: Scaffold Extract Preparationmentioning

confidence: 99%

“…MTT assay was performed according to methods of Peter et al (2010) with slight modifications on scaffold extracts from nanobiocomposite scaffold (NS) and alginate scaffold (AS) groups. Osteoblast were seeded in a 96 well plate with a seeding density of 5 × 10 4 cells/well.…”

Section: Scaffold Extract Preparationmentioning

confidence: 99%

Cytotoxicity and Oxidative Stress Evaluation of Alginate/Cockle Shell Powder Nanobiocomposite Bone Scaffold on Osteoblast

Ahmad

Bharatham

Hamid

et al. 2017

JSKM

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Nanocomposite scaffolds of bioactive glass ceramic nanoparticles disseminated chitosan matrix for tissue engineering applications

Cited by 182 publications

References 31 publications

Biomaterials and Sol–Gel Process: A Methodology for the Preparation of Functional Materials

Biomaterials and Sol–Gel Process: A Methodology for the Preparation of Functional Materials

Calcium Phosphate Coatings by Sol-Gel on Acrylonitrile-butadiene-styrene Substrate

Cytotoxicity and Oxidative Stress Evaluation of Alginate/Cockle Shell Powder Nanobiocomposite Bone Scaffold on Osteoblast

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