Nanocomposites Based on Multicomponent Polymer Matrices and Nanofiller Densil for Biomedical Application

Karabanova, L. V.; Gomza, Yu. P.; Nesin, S.D.; Bondaruk, O. M.; Voronin, E. P.; Носач, Л. В.

doi:10.1007/978-3-319-30737-4_38

Cited by 7 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to improve stability and mechanical properties of PHEMA and to maintain its hydrophilicity, the IPN synthesis of this polymer with polyurethane (PU) was proposed [ 12 ]. The introduction into mixed matrix PU/PHEMA of special fillers, in particular nanosized silica with biologically active compounds (BAC) which immobilized on its surface, allows to create composites with specific pharmacological properties [ 13 ]. Adsorption modification of fumed nanosilica allows to convert BAC in highly dispersive state and to obtain their mono- and multimolecular layers on the nanoparticles surface [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Examination of Nanocomposites Based on Poly(2-hydroxyethyl methacrylate) for Medicinal Use

Kukolevska¹,

Геращенко²,

Borysenko³

et al. 2017

Nanoscale Res Lett

View full text Add to dashboard Cite

Preparation of poly(2-hydroxyethyl methacrylate) (PHEMA) based nanocomposites using different approaches such as synthesis with water as the porogen, filling of polymer matrix by silica and formation of interpenetrating polymer networks with polyurethane was demonstrated. Incorporation of various biologically active compounds (BAC) such as metronidazole, decamethoxin, zinc sulphate, silver nitrate or amino acids glycine and tryptophan into nanocomposites was achieved. BAC were introduced into the polymer matrix either (1) directly, or (2) with a solution of colloidal silica, or (3) through immobilization on silica (sol-densil). Morphology of prepared materials was investigated by laser scanning microscopy and low-vacuum scanning electron microscopy. In vacuum freeze-drying, prior imaging was proposed for improving visualization of the porous structure of composites. The interaction between PHEMA matrix and silica filler was investigated by IR spectroscopy. Adsorption of 2-hydroxyethyl methacrylate and BAC from aqueous solution on the silica surface was also examined. Phase composition and thermal stability of composites were studied by the differential thermogravimetry/differential thermal analysis. Release of BAC into water medium from prepared composites were shown to depend on the synthetic method and differed significantly. Obtained PHEMA-base materials which are characterized by controlled release of BAC have a strong potential for application in manufacturing of different surgical devices like implants, catheters and drainages.

show abstract

Section: Introductionmentioning

confidence: 99%