Nanocomposites with Spatially Separated Functionalities for Combined Imaging and Magnetolytic Therapy

Abstract

Compact nanostructures with highly integrated functionalities are of considerable current interest to drug delivery, multimodality imaging, and electronic devices. A key challenge, however, is how to combine individual components together without interfering or sacrificing their original electronic and optical properties. Here, we demonstrate a new class of nanocomposites with spatially separated functionalities. We further demonstrate magnetic field modulated imaging and an innovative application of this technology in cancer cell treatment, magnetolytic therapy, based on magnetically controlled mechanical damage to cell membranes.

Fabrication of Janus particles composed of poly (lactic-co-glycolic) acid and hard fat using a solvent evaporation method

“…Janus particles have been reported to show unique properties that conventional homogeneous particles do not possess, and have been proposed for use in various applications including as amphiphilic surfactants (16), elementary particles of the display in an electric field (17), and particles for magnetolytic therapy (18). Recently, the pulmonary delivery of hydrophilic and hydrophobic anticancer drugs has been reported (19).…”

Recent Advances in the Emulsion Solvent Evaporation Technique for the Preparation of Nanoparticles and Nanocapsules

“…the metal nanoparticles segregate in one type of lamellae in onion-like nanoparticles [78][79][80], form isotropic surface structures [81,82] (Fig. 6), or can be anisotropic with regard to the particle geometry.…”

Biomaterials in the nano-era

“…It is clear that applications of many different NPs are involved in such systems, especially quantum dot fluorescence emitters and their nano-technologies. There is much work going on to develop useful "feed-back" systems combining imaging and delivery systems with NPs such as Quantum Dots [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46]. 6 DNA will be critical to future nano-and picoscale applications DNA is likely to be the key molecule in the future nanoscale applications.…”