Nanoconstruction on Living Cell Surfaces with Cucurbit[7]uril-Based Supramolecular Polymer Chemistry: Toward Cell-Based Delivery of Bio-Orthogonal Catalytic Systems

Huang, Fang; Liu, Jiaxiong; Li, Mengru; Liu, Yiliu

doi:10.1021/jacs.3c10295

Cited by 4 publications

(4 citation statements)

References 71 publications

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“…These molecules include host molecules like cucurbiturils, calixarenes, crown ethers and porphyrins, and guest molecules like ferrocene, adamantane and azobenzene . Recent studies show host-guest interactions being used in the coating of living cells, specifically bone marrow mesenchymal stem cells (BMSCs), further demonstrating the versatility of LbL in its use of biological matter …”

Section: A Background To Layer-by-layermentioning

confidence: 99%

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Layer-by-Layer Nanoparticle Assembly for Biomedicine: Mechanisms, Technologies, and Advancement via Acoustofluidics

Rowland,

Aghakhani,

Whalley

et al. 2024

ACS Appl. Nano Mater.

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The deposition of thin films plays a crucial role in surface engineering, tailoring structural modifications, and functionalization across diverse applications. Layer-by-layer self-assembly, a prominent thin-film deposition method, has witnessed substantial growth since its mid-20th-century inception, driven by the discovery of eligible materials and innovative assembly technologies. Of these materials, micro-and nanoscopic substrates have received far less interest than their macroscopic counterparts; however, this is changing. The catalogue of eligible materials, including nanoparticles, quantum dots, polymers, proteins, cells and liposomes, along with some wellestablished layer-by-layer technologies, have combined to unlock impactful applications in biomedicine, as well as other areas like food fortification, and water remediation. To access these fields, several wellestablished technologies have been used, including tangential flow filtration, fluidized bed, atomization, electrophoretic assembly, and dielectrophoresis. Despite the invention of these technologies, the field of particle layer-by-layer still requires further technological development to achieve a high-yield, automatable, and industrially ready process, a requirement for the diverse, reactionary field of biomedicine and high-throughput pharmaceutical industry. This review provides a background on layer-by-layer, focusing on how its constituent building blocks and bonding mechanisms enable unmatched versatility. The discussion then extends to established and recent technologies employed for coating micro-and nanoscopic matter, evaluating their drawbacks and advantages, and highlighting promising areas in microfluidic approaches, where one distinctly auspicious technology emerges, acoustofluidics. The review also explores the potential and demonstrated application of acoustofluidics in layer-by-layer technology, as well as analyzing existing acoustofluidic technologies beyond LbL coating in areas such as cell trapping, cell sorting, and multidimensional particle manipulation. Finally, the review concludes with future perspectives on layer-by-layer nanoparticle coating and the potential impact of integrating acoustofluidic methods.

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Section: A Background To Layer-by-layermentioning

confidence: 99%

“… 39 Recent studies show host-guest interactions being used in the coating of living cells, specifically bone marrow mesenchymal stem cells (BMSCs), further demonstrating the versatility of LbL in its use of biological matter. 70 …”

Section: A Background To Layer-by-layermentioning

confidence: 99%

Layer-by-Layer Nanoparticle Assembly for Biomedicine: Mechanisms, Technologies, and Advancement via Acoustofluidics

Rowland,

Aghakhani,

Whalley

et al. 2024

ACS Appl. Nano Mater.

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“…The host–guest complexation based on cavity-bearing macrocycles have recently stimulated an upsurge of interest in biomedical science and materials, mainly due to the dynamic reversibility of noncovalent interactions. − This feature can allow us to design and fabricate more advanced supramolecular nanoassemblies for disease diagnostics and therapeutics. − In this regard, two representative macrocycles, cyclodextrins (CDs) and cucurbiturils (CBs), have been drawn into the limelight because of their immense advantages in molecular recognition and assembly. Concretely, the former as a family of glucose-derived cyclic oligomers can be functionalized to accommodate diverse guests mainly through hydrophobic interactions. , The CD-involved active pharmaceutical ingredients can dramatically enhance water solubility, environmental adaptability, delivery efficiency of parent drugs, thus making many success stories from fundamental research to practical application. − The latter as a family of glycoluril-derived cyclic oligomers can selectively encapsulate positively charged guests via hydrophobic and ion–dipole interactions. − Therefore, given their complementary molecular binding properties, the combined use of CDs and CBs in a single supramolecular entity represents an increasingly significant and feasible strategy in attaining biocompatible nanoassemblies with elaborate biofunctions. , …”

Section: Introductionmentioning

confidence: 99%

Cucurbituril-Based Porphyrin Cascade Assembly for Cell Imaging and Targeted Drug Delivery

Yuan,

Xu,

Song

et al. 2024

ACS Appl. Polym. Mater.

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Supramolecular assemblies based on multiple host−guest interactions have aroused widespread interest in the fabrication of innovative biomaterials. In this work, a combinational nanosupramolecule is constructed by an orthogonal two-step self-assembling process. The generation efficiency of reactive oxygen species and fluorescence emission intensity of pyridiniumappended porphyrin are greatly enhanced upon inclusion complexation with cucurbit[8]uril. Meanwhile, the introduction of β-cyclodextrin-grafted hyaluronic acid can facilitate the formation of secondary assemblies and endow them with the desired targeting ability toward cancer cells. After carrying doxorubicin hydrochloride as the loaded cargo, the resultant supramolecular nanoparticles exhibit much higher anticancer activity at the cellular level upon the near-infrared light irradiation. To be envisioned, such nanosupramolecular assemblies featuring both advantageous photodynamic and chemotherapeutic effects may be developed as more promising nanoplatforms for disease diagnosis and treatment.

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“…For possible application as biomaterials, supramolecular polymers have to possess high stability and solubility in water. 8–10 For this purpose, the host–guest inclusion of macrocyclic hosts, such as cyclodextrins, 11–13 cucurbiturils 14–18 and pillararenes, 19,20 for hydrophobic monomeric or dimeric guests has been developed to allow for the formation of various crosslinked supramolecular polymers in aqueous solution. A more straightforward strategy for synthesizing water-soluble supramolecular polymers involves the use of multiple ionic interactions as driving forces.…”

Section: Introductionmentioning

confidence: 99%

Assembly of ionic supramolecular polymers using a decacationic pillar[5]arene to noncovalently crosslink hyaluronic acid for short DNA delivery

Li,

Ma,

Liu

et al. 2024

Org. Chem. Front.

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Nanoconstruction on Living Cell Surfaces with Cucurbit[7]uril-Based Supramolecular Polymer Chemistry: Toward Cell-Based Delivery of Bio-Orthogonal Catalytic Systems

Cited by 4 publications

References 71 publications

Layer-by-Layer Nanoparticle Assembly for Biomedicine: Mechanisms, Technologies, and Advancement via Acoustofluidics

Layer-by-Layer Nanoparticle Assembly for Biomedicine: Mechanisms, Technologies, and Advancement via Acoustofluidics

Cucurbituril-Based Porphyrin Cascade Assembly for Cell Imaging and Targeted Drug Delivery

Assembly of ionic supramolecular polymers using a decacationic pillar[5]arene to noncovalently crosslink hyaluronic acid for short DNA delivery

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