Nanocrystalline hydroxyapatite and calcium sulphate as biodegradable composite carrier material for local delivery of antibiotics in bone infections

Rauschmann, Michael; Wichelhaus, Thomas A.; Stirnal, Volker; Dingeldein, E.; Zichner, Ludwig; Schnettler, Reinhard; Alt, Volker

doi:10.1016/j.biomaterials.2004.06.045

Cited by 329 publications

(217 citation statements)

References 18 publications

Supporting

Mentioning

193

Contrasting

Unclassified

Order By: Relevance

“…Recently, mesoporous materials become one of hotspots in the drug delivery systems, especially as implantable local-delivery devices for bone tissue repair (ValletRegí et al, 2007;Manzano & Vallet-Regi, 2010). Various systems have been developed as drug delivery systems, such as biodegradable hydroxyapatite, calcium phosphate, bioglasses, and mesoporous silica (Lai et al, 2003;Cavallaro et al, 2004;Rauschmann et al, 2005;Slowing et al, 2007;Shi et al, 2009;López-Noriega et al, 2010;Zhu et al, 2010;Yang et al, 2012;Wu et al, 2012). They have gained enhanced interest as drug storage and release carrier due to their large surface area and pore volume, uniform and adjustable pore, and easily modified surface features, conducive to site specific delivery.…”

Section: Introductionmentioning

confidence: 99%

In vivodrug release and antibacterial properties of vancomycin loaded hydroxyapatite/chitosan composite

Zhang

Wang

et al. 2012

Drug Delivery

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

In vivodrug release and antibacterial properties of vancomycin loaded hydroxyapatite/chitosan composite

Zhang

Wang

et al. 2012

Drug Delivery

View full text Add to dashboard Cite

“…Various kinds of materials also had been used, such as calcium phosphate [25], calcium sulfate (plaster of Paris) [20,23,24], chitosan [1,2], polyethylmethacrylate/n-butyl methacrylate [22] and hydroxyapatite ceramic [28]. In addition, various antibiotics had been employed to prepare antib i o t i c b e a d s , s u c h a s g e n t a m i c i n , t o b r a m y c i n , cephalosporin, polymyxin and vancomycin [2,9,19,25,27,28].…”

mentioning

confidence: 99%

Elution Profiles of Cefazolin from PMMA and Calcium Sulfate Beads Prepared from Commercial Cefazolin Formulations

Udomkusonsri

Kaewmokul

Arthitvong

et al. 2012

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. Antibiotic beads have become popular for the treatment of local bacterial infections. The preparation of antibiotic beads from commercial pharmaceutical antibiotics is a convenient method in clinic. The elution characteristics of cefazolin from polymethylmethacrylate (PMMA) (SmartSet HV, Depuy I and Cemfix 3) beads and calcium sulfate beads were studied. Commercial cefazolin formulation was incorporated in PMMA or calcium sulfate at 1 g cefazolin /10 g of matrix substances to form beads. The concentrations of eluted cefazolin during 15 days were greater than MIC for Staphylococcus aureus (ATCC 25923). The eluted cefazolin concentrations were in the range of 3.6  1.2 to 4.6  0.4 mg for PMMA beads and 15.4  1.7 mg for calcium sulfate beads. The accumulated eluted cefazolin from PMMA beads and calcium sulfate beads for 15 days were 34.41  3.93 to 38.67  3.04% and 95.94  3.93%, respectively. The various storage conditions; at room temperature or 4C, with or without light-protection, for 6 months had little effects on the amounts of eluted cefazolin. The results showed both in-housed cefazolin-PMMA beads and cefazolin-calcium sulfate beads could be the effective tools for the treatment of local bacterial infections.

show abstract

“…NanoHA has already been studied as a potential material for drug-delivery systems, namely with vancomycin. 3,11 Among the numerous forms of HA available for clinical applications, porous granules are more advantageous in cases of bone defects or hollows of irregular shapes, 9 as it happens in patients with osteomyelitis. 1 Type I collagen is a natural polymer present in bone 12 that has been increasingly used in tissue engineering and repair.…”

Section: Methodsmentioning

confidence: 99%

Heparinized nanohydroxyapatite/collagen granules for controlled release of vancomycin

Coelho

Sousa

Monteiro

2015

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

The purpose of this study was to develop a bone substitute material capable of preventing or treating osteomyelitis through a sustainable release of vancomycin and simultaneously inducing bone regeneration. Porous heparinized nanohydroxyapatite (nanoHA)/collagen granules were characterized using scanning electron microscopy, microcomputed tomography and attenuated total reflectance Fourier transform infrared spectroscopy. After vancomycin adsorption onto the granules, its releasing profile was studied by UV molecular absorption spectroscopy. The heparinized granules presented a more sustainable release over time, in comparison with nonheparinized nanoHA and nanoHA/collagen granules. Vancomycin was released for 360 h and proved to be bioactive until 216 h. Staphylococcus aureus adhesion was higher on granules containing collagen, guiding the bacteria to the material with antibiotic, improving their eradication. Moreover, cytotoxicity of the released vancomycin was assessed using osteoblast cultures, and after 14 days of culture in the presence of vancomycin, cells were able to remain viable, increasing their metabolic activity and colonizing the granules, as observed by scanning electron microscopy and confocal laser scanning microscopy. These findings suggest that heparinized nanoHA/collagen granules are a promising material to improve the treatment of osteomyelitis, as they are capable of releasing vancomycin, eliminating the bacteria, and presented morphological and chemical characteristics to induce bone regeneration.

show abstract

Nanocrystalline hydroxyapatite and calcium sulphate as biodegradable composite carrier material for local delivery of antibiotics in bone infections

Cited by 329 publications

References 18 publications

In vivodrug release and antibacterial properties of vancomycin loaded hydroxyapatite/chitosan composite

In vivodrug release and antibacterial properties of vancomycin loaded hydroxyapatite/chitosan composite

Elution Profiles of Cefazolin from PMMA and Calcium Sulfate Beads Prepared from Commercial Cefazolin Formulations

Heparinized nanohydroxyapatite/collagen granules for controlled release of vancomycin

Contact Info

Product

Resources

About