Nanocurcumin protects cardiomyoblasts H9c2 from hypoxia-induced hypertrophy and apoptosis by improving oxidative balance

Nehra, Sarita; Bhardwaj, Varun; Kalra, Namita; Ganju, Lilly; Bansal, Anju; Saxena, Shweta; Saraswat, Deepika

doi:10.1007/s13105-015-0405-0

Cited by 29 publications

(22 citation statements)

References 41 publications

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“…Moreover, Nanocurcumin ameliorated hypoxia-induced hypertrophy and apoptosis in H9c2 cells by stabilizing HIF-1α protein and accumulation (Nehra et al, 2015). This could be the mechanism through which curcumin induces EPO expression in the current study.…”

Section: Discussionsupporting

confidence: 53%

Cardioprotective Effects of Curcumin Against Diabetes and Nicotine-Combined Oxidative Stress

Ibrahim¹,

Soliman²,

Mahmoud³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Diabetic cardiomyopathy (DCM) develop through oxidative stress-induced myocardial cell apoptosis that cause cardiac tissue damage resulting in hemodynamics disturbance while Cigarette Smoking (CS) is associated with a significant increase in the risk of recurrent ventricular tachyarrhythmia in ischemic and non-ischemic cardiomyopathy patients caused by oxidative stress. Curcuma longa extract (curcumin) is known to protect against hyperglycemia-induced oxidative stress. This brought in mind to investigate the probability of the crcumin ability to ameliorate the combined diabetes and smoking induced oxidative stress caused DCM Materials and Methods: Diabetic rats were administered nicotine to investigate the effect of the combined oxidative stress of diabetes and nicotine. Moreover, curcumin was administered to examine its protective effect on possible oxidative stress induced diabetes and nicotine. Results: Nicotine administration in a dose of 1.5 mg/kg to diabetic rats increased the oxidative stress. This occurs through elevation of plasma nitric oxide (NO) and upregulation of cardiac tissue inducible nitric oxide synthase (iNOS) and Endothelin-1 mRNA expressions, in addition to elevation of plasma triglycerides (TG), and LDL and reduction of HDL levels. Nicotine administration also reduced the cardiac tissue protective mechanism through reduction of plasma superoxide dismutase (SOD), cardiac tissue Erythropoietin (EPO), vascular endothelial growth factor (VEGF) isoforms and VEGF receptor mRNA expressions. These combined oxidative stresses were manifested by elevation of the plasma cardiac markers troponin I and creatine kinase (CK-MB). Supplementation of curcumin prevented the diabetic and nicotineinduced oxidative stress through reduction of plasma NO and iNOS and Endothelin-1 mRNA expressions to their control levels and elevation of plasma SOD and upregulation of cardiac tissue Erythropoietin (EPO), vascular endothelial growth factor (VEGF) isoforms and VEGF receptor mRNA expressions. This curcumin protective effect of the cardiac tissue was manifested by normalization of the plasma cardiac marker troponin I and CK-MB. Conclusion: These results strongly confirmed that curcumin protected cardiac tissues from the combined oxidative stress induced by diabetes and nicotine.

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Section: Discussionsupporting

confidence: 53%

Cardioprotective Effects of Curcumin Against Diabetes and Nicotine-Combined Oxidative Stress

Ibrahim¹,

Soliman²,

Mahmoud³

et al. 2017

Afr J Tradit Complement Altern Med

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“…A significant increase in its bioaccessibility was also obtained by excipient food emulsions technique (Zou et al, 2015) and nanotized curcumin (Nehra et al, 2015).…”

Section: A N U S C R I P Tmentioning

confidence: 94%

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

Ghosh

Banerjee

Sil

2015

Food and Chemical Toxicology

445

250

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“…Nehra et al evaluated the effect of nanocurcumin after hypoxia. H9c2 cardiomyocytes treated with nanocurcumin (50 µM), compared to cells treated with curcumin, showed reduced hypertrophy and apoptosis [135]. In addition, nanocurcumin (50 ng/mL) inhibited the hypertrophy, reduced necrosis and ROS generation, restored the mitochondrial membrane potential and glucose transporters and increased ATP levels in primary human ventricular cardiomyocytes (HVCM) [136].…”

Section: In Vitro Effects Of Polyphenols Against Oxidative Stress-mentioning

confidence: 99%

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

et al. 2017

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Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes nuclear and mitochondrial DNA damage, denaturation of intracellular proteins, lipid peroxidation and inflammation. Oxidative or nitrosative stress-mediated injury lead to cardiomyocytes apoptosis or necrosis. The reactive oxygen (ROS) and nitrogen species (RNS) concentration is dependent on their production and on the expression and activity of anti-oxidant enzymes. Polyphenols are a large group of natural compounds ubiquitously expressed in plants, and epidemiological studies have shown associations between a diet rich in polyphenols and the prevention of various ROS-mediated human diseases. Polyphenols reduce cardiomyocytes damage, necrosis, apoptosis, infarct size and improve cardiac function by decreasing oxidative stress-induced production of ROS or RNS. These effects are achieved by the ability of polyphenols to modulate the expression and activity of anti-oxidant enzymes and several signaling pathways involved in cells survival. This report reviews current knowledge on the potential anti-oxidative effects of polyphenols to control the cardiotoxicity induced by ROS and RNS stress.

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Nanocurcumin protects cardiomyoblasts H9c2 from hypoxia-induced hypertrophy and apoptosis by improving oxidative balance

Cited by 29 publications

References 41 publications

Cardioprotective Effects of Curcumin Against Diabetes and Nicotine-Combined Oxidative Stress

Cardioprotective Effects of Curcumin Against Diabetes and Nicotine-Combined Oxidative Stress

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

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