Nanodelivery of natural isothiocyanates as a cancer therapeutic

Wang, Qi; Bao, Yongping

doi:10.1016/j.freeradbiomed.2021.02.044

Cited by 36 publications

(30 citation statements)

References 167 publications

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“…A diet rich in cruciferous vegetables seems to provide SFN, I3C, and DIM in sufficient amounts for the prevention of many types of cancer, including those that are hormone-related, such as breast, ovary, uterus, and prostate neoplasms [ 172 , 173 , 174 ]. In contrast, to achieve therapeutic concentrations of SFN, I3C, and DIM, the intake of these compounds in the form of dietary supplements seems to be required [ 40 , 175 ].…”

Section: Nutraceuticalsmentioning

confidence: 99%

“…The exploitation of SFN by the nutraceutical industry has faced some challenges because this ITC shows high lipophilicity, low aqueous solubility, and poor stability due to sensitivity to oxygen, heat, and alkaline conditions. However, the use of nanotechnology has allowed the increase in the aqueous solubility and bioavailability of SFN through the development of formulations such as polymeric nanoparticles, magnetic nanoparticles, micelles, liposomes, and carbon dots [ 175 ].…”

Section: Nutraceuticalsmentioning

confidence: 99%

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The Anticancer Potential of Plant-Derived Nutraceuticals via the Modulation of Gene Expression

Vranceanu

Galimberti

Banc

et al. 2022

Plants

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Current studies show that approximately one-third of all cancer-related deaths are linked to diet and several cancer forms are preventable with balanced nutrition, due to dietary compounds being able to reverse epigenetic abnormalities. An appropriate diet in cancer patients can lead to changes in gene expression and enhance the efficacy of therapy. It has been demonstrated that nutraceuticals can act as powerful antioxidants at the cellular level as well as anticarcinogenic agents. This review is focused on the best studies on worldwide-available plant-derived nutraceuticals: curcumin, resveratrol, sulforaphane, indole-3-carbinol, quercetin, astaxanthin, epigallocatechin-3-gallate, and lycopene. These compounds have an enhanced effect on epigenetic changes such as histone modification via HDAC (histone deacetylase), HAT (histone acetyltransferase) inhibition, DNMT (DNA methyltransferase) inhibition, and non-coding RNA expression. All of these nutraceuticals are reported to positively modulate the epigenome, reducing cancer incidence. Furthermore, the current review addresses the issue of the low bioavailability of nutraceuticals and how to overcome the drawbacks related to their oral administration. Understanding the mechanisms by which nutraceuticals influence gene expression will allow their incorporation into an “epigenetic diet” that could be further capitalized on in the therapy of cancer.

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Section: Nutraceuticalsmentioning

confidence: 99%

Section: Nutraceuticalsmentioning

confidence: 99%

The Anticancer Potential of Plant-Derived Nutraceuticals via the Modulation of Gene Expression

Vranceanu

Galimberti

Banc

et al. 2022

Plants

View full text Add to dashboard Cite

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“…It can be used to sensitize drug-resistant colon cancer to chemotherapy. Isothiocyanates (ITCs) that occur naturally are bioactive hydrolysis products of thioglucosides from cruciferous vegetables (CVs) with antioxidant, anti-inflammatory, and anticancer properties [95]. In an antiproliferation experiment, Psurski et al [96] detected significantly increased caspase-3 activity in dMBITC-pretreated LoVoDX cells but no significant change in caspase-3 activity in dMBITC-pretreated LoVo-sensitive cells.…”

Section: Doxorubicin (Adm)mentioning

confidence: 99%

The Synergism of Natural Compounds and Conventional Therapeutics against Colorectal Cancer Progression and Metastasis

Liang¹,

Xie²,

Shen³

et al. 2022

Front. Biosci. (Landmark Ed)

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Cancer progression and metastases are the leading causes of poor outcomes in patients with colon cancer. Colon cancer metastasis is a multigene, multistep, multistage complex process in which target genes, microRNAs, epithelial-stromal transformation, tumour stem cells, the tumour microenvironment, and various cell signalling pathways are implicated in the progression and metastasis of colon cancer. Although conventional therapies have made significant advances in treating the progression and metastasis of colorectal cancer, they have failed to improve survival outcomes. Natural compounds may have more significant potential in preventing and treating colon cancer. Active natural compounds exert their antitumor effects by inducing tumour cell differentiation, promoting tumour cell apoptosis, inhibiting tumour vascular growth, and regulating immunity. Natural compounds, combined with conventional therapies, can target mutant genes and various cellular signalling pathways, inhibit epithelial-stromal transformation, and improve the tumour microenvironment to inhibit tumour progression and metastasis. The synergism of natural compounds and conventional therapeutics has the potential to become a promising therapy for treating colorectal cancer progression and metastases.

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“…In addition, the effect of the skin barrier hinders the efficient delivery of drugs, thereby making it difficult to predict the transdermal process. In previous studies, the nanodelivery systems of isothiocyanates have been concerned (Wang & Bao, 2021 ). But researchers have focused more on the development of oral isothiocyanate as an anticancer nanodelivery system.…”

Section: Introductionmentioning

confidence: 99%

Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells

et al. 2022

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Skin photoaging is premature skin aging damage that occurs after repeated exposure to ultraviolet (UV) radiation. Although isothiocyanates extracted from the moringa tree ( Moringa oleifera Lam. ) (MITC) exhibit excellent effects against skin photoaging, its application is restricted because of its characteristics, such as extremely low water solubility, bioavailability, and easy degradation. Currently, flexible nanoliposomes have gained increasing interest as a biocompatible polymer for applications such as transdermal drug delivery. We prepare amphiphilic hyaluronic acid (HA) conjugated with ceramide (CE) to modify nanoliposomes for MITC (HACE/MITC NPs) delivery. The HACE/MITC nanoparticles (NPs) are prepared and characterized for entrapment efficiency, particle size, polydispersity index, zeta potential, in vitro release, in vivo skin permeation, and in vitro protective effect of photoaging. The zeta potential of MITC NPs and HACE/MITC NPs is −24.46 mV and −24.93 mV, respectively. After modification of HACE, the entrapment efficient of MITC liposome increased from 62.54% to 70.67%, and the particle size decreased from 266.1 nm to 192.8 nm. In vivo skin permeation, permeated drug increased from 49.42 to 71.40%. Moreover, the results showed that the entrapment of MITC in nanoliposomes improves its stability, efficacy, and skin permeation. Further, HACE/MITC NPs are favorable for uptake by HaCaT cells without requiring changes in cell morphology, which significantly improves the activities of antioxidant enzymes, scavenges UVB-induced reactive oxygen species, protects skin from damage, and reduces MMP-1, MMP-3, and MMP-9 expression caused by radiation-induced photoaging. Our results strongly suggest that flexible nanoliposomes successfully improved the cell membrane permeation of MITC, and that anti-photoaging and HACE/MITC NPs can potentially be used as candidates for photoaging therapy.

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Nanodelivery of natural isothiocyanates as a cancer therapeutic

Cited by 36 publications

References 167 publications

The Anticancer Potential of Plant-Derived Nutraceuticals via the Modulation of Gene Expression

The Anticancer Potential of Plant-Derived Nutraceuticals via the Modulation of Gene Expression

The Synergism of Natural Compounds and Conventional Therapeutics against Colorectal Cancer Progression and Metastasis

Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells

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