Nanodiagnosis and Nanotreatment of Cardiovascular Diseases: An Overview

Sabir, Fakhara; Barani, Mahmood; Mukhtar, Mahwash; Rahdar, Abbas; Cucchiarini, Magali; Zafar, Muhammad Nadeem; Behl, Tapan; Bungău, Simona

doi:10.3390/chemosensors9040067

Cited by 38 publications

(23 citation statements)

References 175 publications

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“…In the last decades, the use of nanotechnology has revolutionized many biotechnological sectors [ 1 ]. Engineered nanomaterials (ENMs) possess unique physical, electrical, and chemical properties [ 2 ], which have been exploited for widespread applications in electronics, aerospace, medicinal drug delivery, medical devices, biosensors, engineering, bioengineering, food, and cosmetics [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. The increasing use of ENMs and their consequent release into the environment [ 9 , 10 , 11 ] has raised concerns about their safety and their potential risks to human health [ 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

A Complete In Vitro Toxicological Assessment of the Biological Effects of Cerium Oxide Nanoparticles: From Acute Toxicity to Multi-Dose Subchronic Cytotoxicity Study

et al. 2021

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Engineered nanomaterials (ENMs) are of significant relevance due to their unique properties, which have been exploited for widespread applications. Cerium oxide nanoparticles (CeO2-NPs) are one of most exploited ENM in the industry due to their excellent catalytic and multi-enzyme mimetic properties. Thus, the toxicological effects of these ENMs should be further studied. In this study, the acute and subchronic toxicity of CeO2-NPs were assessed. First, an in vitro multi-dose short-term (24 h) toxicological assessment was performed in three different cell lines: A549 and Calu3 were used to represented lung tissue and 3T3 was used as an interstitial tissue model. After that, a sub-chronic toxicity assessment (90 days) of these NPs was carried out on a realistic and well-established reconstituted primary human airway epithelial model (MucilAir™), cultured at the Air–Liquid Interface (ALI), to study the long-term effects of these particles. Results showed minor toxicity of CeO2-NPs in acute exposures. However, in subchronic exposures, cytotoxic and inflammatory responses were observed in the human airway epithelial model after 60 days of exposure to CeO2-NPs. These results suggest that acute toxicity approaches may underestimate the toxicological effect of some ENMs, highlighting the need for subchronic toxicological studies in order to accurately assess the toxicity of ENM and their cumulative effects in organisms.

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Section: Introductionmentioning

confidence: 99%

A Complete In Vitro Toxicological Assessment of the Biological Effects of Cerium Oxide Nanoparticles: From Acute Toxicity to Multi-Dose Subchronic Cytotoxicity Study

et al. 2021

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“…The uses of Nanomaterials are directly linked to medicinal research. They can be used to provide strong alternatives to CVDs [50]. Many novel tactics may be able to improve the effectiveness of these medicines.…”

Section: Applications Of Nanozymes In the Treatment Of Cvdsmentioning

confidence: 99%

Applications of Nanoparticles-based Enzymes in the Diagnosis of Diseases

Haider

2022

Materials Research Foundations

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Nanozymes (NSEs), which are efficient nanomaterials with enzyme-like appearances, have proved themselves highly-stable compared to the natural enzymes. They are also organized with the exclusive fundamental properties of nanomaterials such as luminescence and magnetism. Thus, in the biomedical field, their expansions demonstrate that their catalytic movements have opened up new applications as well as opportunities. Nanozymes are excellent in the informal mass production as well as long term storage. They are also helpful in the field of biomedical technology for the treatment of many diseases. They may incorporate various therapeutically effects in the anti-inflammatory, cytoprotecting, brain diseases and dental biofilms as well as in cardiovascular diseases. They have also performed as impartial therapeutics with other therapeutic approaches to increase antitumor effects. This chapter describes their fascinating applications in therapeutics the associated mechanism.

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“…ROS–based nanotechnology focuses on the ROS–related nano chemistry interface (ROS generation, ROS transition, and ROS scavenging) for improved reaction efficiencies, as well as the ROS-related nanobiology interactions (bioavailability, biodegradability, and biocompatibility) for improved therapeutic outcomes. In recent years, various advanced ROS-based nanotechnologies have been developed and applied to the diagnosis and treatment of cardiovascular illnesses in response to the growing interest of scholars ( 8 ). Inspired by the vast advances in the field of ROS-based nanotechnology for CVD, we present this article regarding ROS-based nanotechnology for CVD via the aid of bibliometric analysis, with the aim of identifying current research advances and further promoting the development of this important field.…”

Section: Introductionmentioning

confidence: 99%

A Bibliometric Analysis of Reactive Oxygen Species Based Nanotechnology for Cardiovascular Diseases

Liang

Liao²,

Zhang³

2022

Front. Cardiovasc. Med.

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Cardiovascular diseases (CVDs) continue to be the leading cause of health problems around the world. Because of its unique properties, reactive oxygen species (ROS)-based nanotechnology offers novel solutions to the diagnosis and treatment of CVDs. In order to identify and further promote the development of ROS-based nanotechnology in CVDs, we here provide a bibliometric analysis. 701 eligible articles about the ROS–based nanotechnology for CVD up to May 26th, 2022, were taken from the Web of Science Core Collection database. The VOSviewer was used to analyze annual publications, countries/institutions, funding agencies, journals and research category, and the research hotspots. From the publication of the first article in 2005 to 2021, the output and the number of citations of articles are on the rise. Based on the bibliometric analysis, we found that the current research focuses on the correlation between diagnosis (sensors and), treatment (oxidative stress, inflammation, and drug delivery) and safety (toxicity). Since 2019, research on nanomedicine and drug delivery has become a hotspot. So, more research in chemistry, materials, biology, and medicine is required to further develop and construct ROS-based nanomaterials.

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Nanodiagnosis and Nanotreatment of Cardiovascular Diseases: An Overview

Cited by 38 publications

References 175 publications

A Complete In Vitro Toxicological Assessment of the Biological Effects of Cerium Oxide Nanoparticles: From Acute Toxicity to Multi-Dose Subchronic Cytotoxicity Study

A Complete In Vitro Toxicological Assessment of the Biological Effects of Cerium Oxide Nanoparticles: From Acute Toxicity to Multi-Dose Subchronic Cytotoxicity Study

Applications of Nanoparticles-based Enzymes in the Diagnosis of Diseases

A Bibliometric Analysis of Reactive Oxygen Species Based Nanotechnology for Cardiovascular Diseases

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