Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances

Пуртов, К. В.; Petunin, A. I.; Burov, A.; Puzyr, A. P.; Bondar, V. S.

doi:10.1007/s11671-010-9526-0

Cited by 107 publications

(66 citation statements)

References 22 publications

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“…4 F-NDP as a platform are capable of diverse functionalization and have been coupled to antibodies for protein detection, adsorbed with small molecules for therapeutic purposes, and even inorganically doped for use as catalysts. [5][6][7] Our previous set of in vitro studies, in which we demonstrated the specific association of the F-NDP NVN -Bit with platelets embedded within plasma clot generated by thrombin-activated rat platelet-rich plasma, provided a first-line "proof of feasibility" for our concept. 4 Since transmission of light across biological tissues is subject to interferences (scatter, absorption, diffraction) by organic and inorganic materials of the tissues, 8 we have primarily focused on the near-infrared (NIR) optical window, which significantly facilitates penetration of light through biological tissues.…”

mentioning

confidence: 82%

Vascular thrombus imaging in vivo via near-infrared fluorescent nanodiamond particles bioengineered with the disintegrin bitistatin (Part II)

Gerstenhaber¹,

Barone²,

Marcinkiewicz³

et al. 2017

IJN

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The aim of this feasibility study was to test the ability of fluorescent nanodiamond particles (F-NDP) covalently conjugated with bitistatin (F-NDP-Bit) to detect vascular blood clots in vivo using extracorporeal near-infrared (NIR) imaging. Specifically, we compared NIR fluorescence properties of F-NDP with N-V (F-NDP NV ) and N-V-N color centers and sizes (100–10,000 nm). Optimal NIR fluorescence and tissue penetration across biological tissues (rat skin, porcine axillary veins, and skin) was obtained for F-NDP NV with a mean diameter of 700 nm. Intravital imaging (using in vivo imaging system [IVIS]) in vitro revealed that F-NDP NV -loaded glass capillaries could be detected across 6 mm of rat red-muscle barrier and 12 mm of porcine skin, which equals the average vertical distance of a human carotid artery bifurcation from the surface of the adjacent skin (14 mm). In vivo, feasibility was demonstrated in a rat model of occlusive blood clots generated using FeCl 3 in the carotid artery bifurcation. Following systemic infusions of F-NDP NV -Bit (3 or 15 mg/kg) via the external carotid artery or femoral vein (N=3), presence of the particles in the thrombi was confirmed both in situ via IVIS, and ex vivo via confocal imaging. The presence of F-NDP NV in the vascular clots was further confirmed by direct counting of fluorescent particles extracted from clots following tissue solubilization. Our data suggest that F-NDP NV -Bit associate with vascular blood clots, presumably by binding of F-NDP NV -Bit to activated platelets within the blood clot. We posit that F-NDP NV -Bit could serve as a noninvasive platform for identification of vascular thrombi using NIR energy monitored by an extracorporeal device.

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mentioning

confidence: 82%

Vascular thrombus imaging in vivo via near-infrared fluorescent nanodiamond particles bioengineered with the disintegrin bitistatin (Part II)

Gerstenhaber¹,

Barone²,

Marcinkiewicz³

et al. 2017

IJN

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“…Their feasibility of applications due to their biocompatibility and high temperature resistant, make them an interesting matrix for the development of new low-dimensional carbon nanomaterials [25,26,66].…”

Section: Intermatrix Synthesis Cds-qds In Nanodiamonds (Cds-qds@nds)mentioning

confidence: 99%

“…Nanodimonds (NDs) [23] , [24,25], which is other carbon nanoallotrope, exhibit interesting mechanical and optical properties, high surface areas and tuneable surface structures [25]. Moreover, they are non-toxic, which makes them suitable to biomedical applications, a feasible alternative as nanocarriers for addressed delivery of drugs and biolabeling [26], [27].…”

Section: Introductionmentioning

confidence: 99%

Intermatrix Synthesis as a rapid, inexpensive and reproducible methodology for the in situ functionalization of nanostructured surfaces with quantum dots

Bastos-Arrieta

Muñoz

Stenbock-Fermor

et al. 2016

Applied Surface Science

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Multiwall Carbon Nanotubes (MWCNTs) and Nanodiamonds (NDs). The synthetic route takes advantage of the ion exchange functionality of the reactive surfaces for the loading of the QDs precursor and consequent QDs appearance by precipitation. The benefits of such modified nanomaterials were studied using CdS-QDs@MWCNTs hybrid-nanomaterials.CdS-QDs@MWCNTs has been used as conducting filler for the preparation of electrochemical nanocomposite sensors, which present electrocatalytic properties. Finally,

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“…Only in few cases the nuclear localization of NDs has been reported, the most showed only perinuclear localization. The nuclear delivery is fundamental when DNA Derivatized NDs bind to the target antigen immobilized on Sepharose 6B matrix through antibody-antigen interaction [34] is the loaded material. 20 In an interesting study Perevedentseva et al 31 compare NDs internalization in human cancer and non-cancer cells.…”

Section: Cell Interaction Studies and Cellmentioning

confidence: 99%

Biomedical Applications of Nanodiamonds: An Overview

Passeri¹,

Rinaldi²,

Ingallina³

et al. 2015

j nanosci nanotechnol

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Nanodiamonds are a novel class of nanomaterials which have raised much attention for application in biomedical field, as they combine the possibility of being produced on large scale using relatively inexpensive synthetic processes, of being fluorescent as a consequence of the presence of nitrogen vacancies, of having their surfaces functionalized, and of having good biocompatibility. Among other applications, we mainly focus on drug delivery, including cell interaction, targeting, cancer therapy, gene and protein delivery. In addition, nanodiamonds for bone and dental implants and for antibacterial use is discussed. Techniques for detection and imaging of nanodiamonds in biological tissues are also reviewed, including electron microscopy, fluorescence microscopy, Raman mapping, atomic force microscopy, thermal imaging, magnetic resonance imaging, and positron emission tomography, either in vitro, in vivo, or ex vivo. Toxicological aspects related to the use of nanodiamonds are also discussed. Finally, patents, preclinical and clinical trials based on the use of nanodiamonds for biomedical applications are reviewed.

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Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances

Cited by 107 publications

References 22 publications

Vascular thrombus imaging in vivo via near-infrared fluorescent nanodiamond particles bioengineered with the disintegrin bitistatin (Part II)

Vascular thrombus imaging in vivo via near-infrared fluorescent nanodiamond particles bioengineered with the disintegrin bitistatin (Part II)

Intermatrix Synthesis as a rapid, inexpensive and reproducible methodology for the in situ functionalization of nanostructured surfaces with quantum dots

Biomedical Applications of Nanodiamonds: An Overview

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