Nanoemulsion: an advanced mode of drug delivery system

Jaiswal, Manjit; Dudhe, Rupesh; Sharma, Pramod Kumar

doi:10.1007/s13205-014-0214-0

Cited by 845 publications

(490 citation statements)

References 19 publications

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“…Briefly, BBH nanoemulsion was centrifugally stable with no phase separation during the storage period. The amount of BBH and mean droplet size as well as the polydispersity index (PDI) were generally conform to requirements (Guti errez et al, 2008;Jaiswal et al, 2015), suggesting that BBH-loaded nanoemulsion was stable.…”

Section: Stability Of Bbh Nanoemulsionmentioning

confidence: 76%

Nanoemulsion-based delivery system for enhanced oral bioavailability and Caco-2 cell monolayers permeability of berberine hydrochloride

Lü

et al. 2017

Drug Delivery

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Berberine hydrochloride (BBH) has a variety of pharmacological activities such as antitumor, antimicrobial, anti-inflammation, and reduce irritable bowel syndrome. However, poor stability and low oral bioavailability limited its usage. Herein, an oil-in-water nanoemulsion system of BBH was developed to improve its stability and oral bioavailability. The pseudoternary phase diagrams were constructed for the determination of composition of various nanoemulsions. The nanoemulsions of BBH composed of Labrafil M 1944 CS (oil phase), RH-40 (surfactant), glycerin (co-surfactant), and water (aqueous phase). The O/W nanoemulsion of BBH showed a relative bioavailability of 440.40% compared with unencapsulated BBH and was stable in our 6-month stability study. Further, there was a significant increase in intestinal permeability of BBH as assessed by Caco-2 cell monolayers and a significant reduction in efflux of BBH by the multidrug efflux pump P-glycoprotein. This study confirmed that the nanoemulsion formulation could be used as an alternative oral formulation of BBH to improve its stability, oral bioavailability and permeability.ARTICLE HISTORY

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Section: Stability Of Bbh Nanoemulsionmentioning

confidence: 76%

Nanoemulsion-based delivery system for enhanced oral bioavailability and Caco-2 cell monolayers permeability of berberine hydrochloride

Lü

et al. 2017

Drug Delivery

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“…In contrast, a w/o NE will migrate only slowly (Jaiswal et al 2015). On the other hand, a water soluble dye (methyl orange) was mixed with each CC NE formula.…”

Section: Zeta Potential Measurementmentioning

confidence: 99%

Oral nanoemulsions of candesartan cilexetil: formulation, characterization and in vitro drug release studies

Ali

Hussein

2017

AAPS Open

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Nanoemulsion is considered to be a new and exciting field of research that seeks to exploit the attractive properties of components to improve oral delivery of drugs like candesartan cilexetil used in the management of chronic diseases. Candesartan cilexetil is a lipophilic acidic drug with a half-life of about (5-10) hour and absolute bioavailability of (14-40%). For this reason, the study target was to formulate and characterize candesartan cilexetil nanoemulsions that could improve solubility, dissolution and stability of the lipophilic drug candesartan cilexetil. The solubility of candesartan cilexetil was checked in various vehicles in order to choose the best solubilizing components for building up an efficient nanoemulsion based on regulating hydrophilic/lipophilic balance (HLB) value above 10, and then pseudo-ternary phase diagram was used as a useful tool to evaluate the nanoemulsion domain. The nanoemulsion formulations were prepared using various concentrations of cinnamon oil, tween 80 with poloxamer mixture and transcutol HP as oil, surfactant mixture and co-surfactant respectively by aqueous titration method at surfactant/co-surfactant ratios of 3:1 and 4:1 and varying the type of poloxamer in each ratio. The prepared nanoemulsions were tested for nanodispersion stability studies, droplet size distribution, polydispersity index, zeta potential, viscosity, filter paper spreadability, dye miscibility, electroconductivity, pH, percent transmittance, surface tension, refractive index, morphology and drug dissolution. It was found that release rate and extent for all prepared nanoformulations were significantly higher (p < 0.05) than marketed tablet formulation as well as plain drug powder. The results demonstrated that, the potential use of this system is a perfect technique for improving solubility and dissolution of candesartan cilexetil.

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“…Due to improved physical stability, and their non-toxic and nonirritant nature, they can be employed in topical drug delivery systems, providing greater absorption of solubilized lipophilic drugs. Apart from that, they can be formulated into a variety of formulation types, such as foams, creams, liquids, sprays and gels (13). There are many topical formulations, like nail lacquers (14)(15)(16)(17), creams (18)(19)(20), ointments (21,22), bio-adhesive patch (23) and solutions (24,25), which are being used for the treatment of nail infections, but gel is being preferred because it fulfils the required dermatological properties, such as thixotropy, greaselessness, emollient and non-staining nature, ease in spreadability, etc.…”

Section: Introductionmentioning

confidence: 99%

Transungual Delivery of Ketoconazole Nanoemulgel for the Effective Management of Onychomycosis

et al. 2016

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Abstract. Ketoconazole (KCZ) nanoemulgel containing permeation enhancer was formulated as a vehicle for transungual drug delivery, and its efficacy to inhibit the growth of onychomycotic dermatophytes was investigated in vitro. Different components of oil-in-water nanoemulsions were moderately agitated by classical titration method and passed through a high-pressure homogenizer to formulate various nanoemulsions, which were further identified by constructing pseudo-ternary phase diagrams. Stressstability testing was carried out for the nanoemulsions, and those that passed these tests were characterized for mean droplet size, zeta potential, morphology, pH, refractive index, viscosity and transmittance. Mean droplet size and zeta potential of the optimized nanoemulsion (NE3) were found to be 77.52 ± 0.92 nm (polydispersity index (PDI) = 0.128 ± 0.035) and −5.44 ± 0.67 mV, respectively. Optimized nanoemulsion was converted into nanoemulgel (NEG 1 ) with 1% (w/w) of gelling agent (Carbopol® Ultrez 21) and 1%-2% (v/v) thioglycolic acid as permeation enhancer, and evaluated for pH, viscosity, spreadability, extrudability, tensile strength and bio-adhesion measurement. In vitro cumulative drug released at the end of 24 h from NE3, NEG 1 and drug suspension were found to be 98.87 ± 1.29, 84.42 ± 2.78% and 54.86 ± 2.19%, respectively. Ex vivo transungual permeation values for KCZ through goat hooves from NE3, NEG 1 and drug suspension were found to be 62.49 ± 2.98, 77.54 ± 2.88% and 38.54 ± 2.54%, respectively, in 24 h. The antifungal effect of NEG 1 on Trichophyton rubrum and Candida albicans showed a significant (p < 0.05) zone of inhibition as compared to drug solution. Skin irritation and histopathology studies on rat skin showed the safe topical use and enhanced permeation of formulated nanoemulgel.

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Nanoemulsion: an advanced mode of drug delivery system

Cited by 845 publications

References 19 publications

Nanoemulsion-based delivery system for enhanced oral bioavailability and Caco-2 cell monolayers permeability of berberine hydrochloride

Nanoemulsion-based delivery system for enhanced oral bioavailability and Caco-2 cell monolayers permeability of berberine hydrochloride

Oral nanoemulsions of candesartan cilexetil: formulation, characterization and in vitro drug release studies

Transungual Delivery of Ketoconazole Nanoemulgel for the Effective Management of Onychomycosis

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