Transungual Delivery of Ketoconazole Nanoemulgel for the Effective Management of Onychomycosis

Mahtab, Asiya; Anwar, Mohammed; Mallick, Neha; Naz, Zrien; Jain, Gaurav K.; Ahmad, Feroz

doi:10.1208/s12249-016-0488-0

Cited by 100 publications

(70 citation statements)

References 44 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistently, the PDI value of 0.045±0.0098 indicated the homogeneity of droplet size. [60][61][62] Next, we evaluated the stability of BD-SNEDDS in simulated harsh GI environment. In general, nano-sized spheres of SNEDDS indicate a huge surface area and surface energy, which may lead to physical and chemical instability under different conditions of pH, temperature change, or gravitational force.…”

Section: Figurementioning

confidence: 99%

Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis

Dou¹,

Zhou²,

Wang³

et al. 2018

IJN

View full text Add to dashboard Cite

BackgroundBruceine D (BD) is a major bioactive component isolated from the traditional Chinese medicinal plant Brucea javanica which has been widely utilized to treat dysentery (also known as ulcerative colitis [UC]).MethodsTo improve the water solubility and absolute bioavailability of BD, we developed a self-nanoemulsifying drug delivery system (SNEDDS) composing of MCT (oil), Solutol HS-15 (surfactant), propylene glycol (co-surfactant) and BD. The physicochemical properties and pharmacokinetics of BD-SNEDDS were characterized, and its anti-UC activity and potential mechanism were evaluated in TNBS-induced UC rat model.ResultsThe prepared nanoemulsion has multiple beneficial aspects including small mean droplet size, low polydispersity index (PDI), high zeta potential (ZP) and excellent stability. Transmission electron microscopy showed that nanoemulsion droplets contained uniform shape and size of globules. Pharmacokinetic studies demonstrated that BD-SNEDDS exhibited enhanced pharmacokinetic parameters as compared with BD-suspension. Moreover, BD-SNEDDS significantly restored the colon length and body weight, reduced disease activity index (DAI) and colon pathology, decreased histological scores, diminished oxidative stress, and suppressed TLR4, MyD88, TRAF6, NF-κB p65 protein expressions in TNBS-induced UC rat model.ConclusionThese results demonstrated that BD-SNEDDS exhibited highly improved oral bioavailability and advanced anti-UC efficacy. In conclusion, our current results provided a foundation for further research of BD-SNEDDS as a potential complementary therapeutic agent for UC treatment.

show abstract

Section: Figurementioning

confidence: 99%

Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis

Dou¹,

Zhou²,

Wang³

et al. 2018

IJN

View full text Add to dashboard Cite

show abstract

“…Before measurement, the sample was diluted with distilled water (1:100 v/v) to avoid multiple scattering effect. 17,18 The micromorphology was then observed using a transmission electron microscope (TEM, HITACHI, HT7700, Japan). 19…”

Section: Droplet Size Zeta Potential and Micromorphologymentioning

confidence: 99%

<p>Ultrasound-Assisted Preparation of Exopolysaccharide/Nystatin Nanoemulsion for Treatment of Vulvovaginal Candidiasis</p>

Song¹,

Fang²,

Cheng³

et al. 2020

IJN

View full text Add to dashboard Cite

Purpose: As one of the classic anti-Canidia albicans (CA) and vulvovaginal candidiasis (VVC) drugs, nystatin (NYS) is limited by poor water solubility and easy aggregation. Traditional NYS vaginal delivery formulations do not fully adapt to the specific environment of the vaginal cavity. The use of exopolysaccharides (EPS) has great application potential in emulsifiers, but its use has not been reported in nanoemulsions. In this work, an EPS/NYS nanoemulsion (ENNE) was developed to improve the activities of NYS against CA and VVC Methods: The ENNE was prepared by ultrasonic method using EPS as an emulsifier, liquid paraffin oil as an oil phase, PEG400 as a co-emulsifier, and NYS as the loaded drug. ENNE preparation was optimized by response surface method. After optimization, in vitro and in vivo analysis of the anti-CA activity; animal experiments; staining with propidium iodide (PI), periodic acid-schiff (PAS), and hematoxylin-eosin (H&E); and cytokine experiments were performed to investigate the therapeutic ability against VVC. Results: The optimal formulation and preparation parameters of ENNE were determined as follows: EPS content of 1.5%, PEG400 content of 3.2%, NYS content of 700 μg/mL, paraffin oil content of 5.0%, ultrasonic time of 15 min, and ultrasonic amplitude of 35%. The ENNE showed an encapsulated structure with an average particle size of 131.1 ± 4.32 nm. ENNE exhibited high storage and pH stability, as well as slow release. The minimum inhibitory concentration (MIC) of ENNE against CA was only 0.125 μg/mL and the inhibition zone was 19.0 ± 0.5 mm, for greatly improved anti-CA effect. The prepared ENNE destroyed the membrane of CA cells, and exhibited good anti-CA effect in vivo and therapeutic ability against VVC. Conclusion: The results of this study will promote the application of EPS in nanotechnology, which should lead to new and effective local drug formulations for treating VVC.

show abstract

“…Nanoemulsions are kinetically stable systems and are formed by using a particular concentration of various components, with no sign of phase separation, creaming or cracking under various stress conditions. The most important feature of nanoemulsions is the mean droplet size, which must be in the nanometric range (Mahtab et al, 2016). The low pressure influence of magnetic stirrer can reduce droplet size of nanoemulsion to achieve the mean droplet size of less than 200 nm, was studied.…”

Section: Optimization Of Nanoemulsion Basismentioning

confidence: 99%

Formulation, optimization, and characterization of snakehead fish (Ophiocephalus Striatus) powder nanoemulgel

Tungadi

Wicita

2020

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

The aim of the present study was to characterize and evaluate nanoemulgel of snakehead fish powder (SFP) for the poorly water-soluble drug. SFP was formulated into nanoemulsion utilizing the best comparison of surfactant, co-surfactant, and oil. Diverse nanoemulsion components (oil, surfactant, and co-surfactant) were chosen based on solvency and emulsification capacity. SFP 0.1% loaded nanoemulsion which tested by stress-stability testing which carried out for all formulations and those that passed these tests were characterized for droplet size, polydispersity index (PDI), zeta potential, pH, viscosity, and transmittance. After that, nanoemulsion was added with 1.5%, 2.0%, and 2.5% of HPMC in different concentrations and mixed until nanoemulgel form and evaluated for pH, viscosity, spreadability, and extrudability measurement. The results of this research showed that SF nanoemulsion produced clear, stable, and transparent formula having the transmittance value 99.87%. Mean droplet size and zeta potential of the optimized nanoemulsion (NE4) were found to be 98.6±0.93 nm (PDI 0.1±0.20) and -57.5±0.3 MV respectively. Meanwhile, the evaluation results of nanoemulgel (NEG) showed NEG 1.5 gave pH 6.0, viscosity 210 cP, spreadability 5.8 g cm/s and extrudability 1.4 g/cm 2 . Otherwise, NEG 2.0 and NEG 2.5 had high viscosity and pH generating low spreading on the skin i.e. 3.9 g cm/s and 2.8 g cm/s respectively. The results of the evaluation and preparation stability test showed a good level of stability of NEG 1.5 with the viscosity and pH by one way ANOVA which did not change significantly.

show abstract

Transungual Delivery of Ketoconazole Nanoemulgel for the Effective Management of Onychomycosis

Cited by 100 publications

References 44 publications

Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis

Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis

<p>Ultrasound-Assisted Preparation of Exopolysaccharide/Nystatin Nanoemulsion for Treatment of Vulvovaginal Candidiasis</p>

Formulation, optimization, and characterization of snakehead fish (Ophiocephalus Striatus) powder nanoemulgel

Contact Info

Product

Resources

About