Nanoemulsion as Targeted Drug Delivery System for Cancer Therapeutics

Mahato, Rubi

doi:10.1166/jpsp.2017.1082

Cited by 56 publications

(36 citation statements)

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“…The low toxicity, controllable uptake, and efficient releasing of drugs, easy access and high solubility, high transparency, and physical sustainability (Acosta, 2009;McClements, 2012;Tadros et al, 2004) have been mentioned as their individual advantages than the other cancer therapy strategies (Yukuyama, Kato, Lobenberg, & Bou-Chacra, 2017). Studies on nanoemulsion delivery systems have focused on their various modifications for passive and active targeting approaches (Mahato, 2017). Therefore, nanoemulsion systems due to their capabilities in increasing the solubility of nonpolar therapeutics are considered as one of the most efficient tools in targeted drug delivery systems (Singh et al, 2017), which can be applied in delivering the nonsoluble essential oils as the natural antioxidants and anticancer therapeutics (Bilia et al, 2014).…”

Section: The Particle Size Of Nanoemulsion Is Between 20 and 200 Nmmentioning

confidence: 99%

Synthesis ofCarum Carviessential oil nanoemulsion, the cytotoxic effect, and expression of caspase 3 gene

et al. 2019

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Scientists are attempting to find novel methods to overcome cancers. Nanoemulsion systems as the novel drug delivery tools have been widely used in cancer therapy. In this study, the Carum Carvi oil nanoemulsions (CCONE) were prepared and its cytotoxic activity was studied on human colon cancer HT‐29 cells using MTT assay. Flow cytometry and Real‐time qPCR were triggered to evaluate the nanoemulsions' apoptotic properties. The results showed a significant negative association between the HT‐29 cancer cell viability and CCONE doses of treatments compared with Huvec normal cells (p value < 0.001). The IC50 values were estimated 12.5 µg/ml and 50 µg/ml for HT‐29 and Huvec, respectively. Moreover, we observed that increasing concentrations of nanoemulsions significantly upregulate Caspase‐3 gene expression. The results showed the CCONE is an efficient novel apoptosis inducer for human colon cancer cells without any undesirable side effects. However, further in vitro and in vivo researches are required. Practical applications Cancer is a complex and usually untreatable disorder. Several types of cancer therapy strategies have been applied widely to overcome cancers. Chemotherapy has been used in various types of cancers. In most cases, not only it had not been effective on cancer cells but also been distractive within normal tissues. According to results, Carum Carvi essential oil nanoemulsions have apoptotic and cytotoxic effects on colon cancer cells (HT‐29). When it comes to cancer of any kind, it's important to realize that no dietary supplement can fully treat, cure, or prevent cancer. However, there are some supplements that can potentially decrease the risk of cancer. Nanoemulsions present several advantages including the ability to incorporate hydrophilic, amphiphilic, and lipophilic excipient ingredients, high physical stability, and rapid gastrointestinal digestibility. The Carum Carvi essential oil nanoemulsion can also be applied as an effective food supplement due to its potent apoptotic activity.

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Section: The Particle Size Of Nanoemulsion Is Between 20 and 200 Nmmentioning

confidence: 99%

Synthesis ofCarum Carviessential oil nanoemulsion, the cytotoxic effect, and expression of caspase 3 gene

et al. 2019

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“…Primo et al denominated magnetic nanoemulsion which enhances the diffusion of the drug when associated with Foscanfor the application of photodynamic therapy [41]. Mahato et al reported that nanoemulsionsserve as the effective drug delivery as a carrier of nucleic acids, drugs as well as imaging agent which has been widely used for disease diagnostics, imaging and therapy [42]. Jasmina et al prepared nanoemulsions by both higher energy and lower energy emulsion methods and concluded that low energy methods are greatly recognized by the manufacturers as they do not require any expensive equipment [43].…”

Section: Nanoemulsionsmentioning

confidence: 99%

Novel Nanocarriers for Ethnopharmacological Formulations

Sivapriya¹,

Ponnarmadha²,

Nazeer³

et al. 2018

Int J App Pharm

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A numerous novel drug delivery system has been emerged by combining herbal medicine with nanotechnology to administer drugs encompassing the enhancement of compatibility and efficacy. The herbal phytoconstituents are compatible compared to the chemical active pharmaceutical ingredients (APIs). But the therapeutic consequence of the phytoconstituent is limited due to poor aqueous solubility. Therefore, the demand to develop a system which improves the solubility of the phytomedicine is mounting rapidly. Nanotechnology plays a vital role in increasing the solubility, enhancing the bioavailability and improving the drug specificity of bioactive constituents. Nanosystems such as liposomes, nanoparticles, phytosomes, ethosomes, nanoemulsions and solid lipid nanoparticles are used to deliver the bioactive constituent at an adequate dose to the site of action and during the entire treatment period. The current review discusses the various novel drug delivery systems which have been developed to attain better therapeutic response of the herbal drug.

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“…This poor selectivity of the chemotherapy drugs can lead to damage to surrounding normal growing cells, making them inadmissible for long term treatment. This poor selectivity of the chemotherapy drugs can lead to damage to surrounding normal growing cells (Mahato 2017). Therefore, it is required to discover safe as well as e cient therapeutic tools to aide undesirable side effects in human liver cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Anticancer activity of food grade nanoemulsions on hepatic cancer cells: a comparative study

Hassan¹,

Khan²

2020

Preprint

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The current study was aimed to prepare stable NEs from plant oils to evaluate their cytotoxic effect on HepG2 cells. Oils form three different samples (flax seeds, cloves and olives) were extracted. NEs from these oils were prepared separately by ultrasonication method. After characterization of stable NEs, they were evaluated for their antioxidant and anticancer activities. Extracted oils and their NEs were applied separately to HepG2 cell line to construct a comparison and MTT assay was used for this purpose. Prepared NEs were found more effective against cancer cell line as compared to their respective oils. MTT assay showed efficacy of NEs in reducing cell viability with IC50 value of 10 µl (flax seed oil), 25 µl (clove oil NE) and 1 µl (olive oil NE), and was safe to normal cells. The results of the current study revealed that NEs prepared from flax seed, clove and olive oil have the potential for further development as anticancer agents.

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Nanoemulsion as Targeted Drug Delivery System for Cancer Therapeutics

Cited by 56 publications

References 0 publications

Synthesis ofCarum Carviessential oil nanoemulsion, the cytotoxic effect, and expression of caspase 3 gene

Synthesis ofCarum Carviessential oil nanoemulsion, the cytotoxic effect, and expression of caspase 3 gene

Novel Nanocarriers for Ethnopharmacological Formulations

Anticancer activity of food grade nanoemulsions on hepatic cancer cells: a comparative study

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