Nanofibrous matrixes with biologically active hydroxybenzophenazine pyrazolone compound for cancer theranostics

Kandhasamy, Subramani; Ramanathan, Giriprasath; Thangavelu, Muthukumar; Thyagarajan, Sitalakshmi; Maheswari, Narayanan Uma; Santhanakrishnan, V. P.; Uma, T.; Perumal, Paramasivan T.

doi:10.1016/j.msec.2017.01.001

Cited by 14 publications

(5 citation statements)

References 49 publications

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“…Numerous reports are devoted to the preparation of materials by solvent casting or compression molding of PHB blends with poly(ε-caprolactone) (PCL) [16][17][18][19]. The electrospinning of mixed PHB/PCL solutions has been reported [20,21]. However, there are still no reports on the simultaneous electrospinning of separate PHB and PCL spinning solutions.…”

Section: Introductionmentioning

confidence: 99%

Modulating the Mechanical Properties of Electrospun PHB/PCL Materials by Using Different Types of Collectors and Heat Sealing

et al. 2020

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Two-component fibrous materials based on poly(3-hydroxybutyrate) (PHB, Tm = 160 °C) and poly(ε-caprolactone) (PCL, Tm = 60 °C) were successfully fabricated by dual-jet electrospinning of their separate spinning solutions. The desired alignment of the fibers that compose PHB/PCL mats was achieved by using three types of rotating collectors—drum (smooth), blade and grid. Additional fiber alignment in the direction of collector rotation was achieved by rotating at 2200 rpm. Moreover, the selected concentration of PCL spinning solution resulted in fibers with spindle-like defects along their length. Thus, “segment” sealing of the PHB (high-melting) fibers by the molten PCL (low-melting) fibers/defects sites was achieved after heating the PHB/PCL mats above the melting temperature (Tm) of PCL. The surface morphology, thermal behavior and mechanical properties of the PHB/PCL mats before and after thermal treatment were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC) and mechanical tests. The results indicated that regardless of the cutting direction of the specimens (0° or 90°), thermal treated PHB/PCL mats reveal enhanced mechanical properties. Therefore, this work provides an easily feasible route for the fabrication of electrospun PHB/PCL mats with tunable mechanical properties and improved performance.

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Section: Introductionmentioning

confidence: 99%

Modulating the Mechanical Properties of Electrospun PHB/PCL Materials by Using Different Types of Collectors and Heat Sealing

et al. 2020

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“…Initially there occurs condensation between 3 with 2 to give the intermediate benzo[ a ]phenazin-5-ol 245, the second step is an aldol-type condensation that takes place between aromatic aldehyde with 245, resulting in situ C C bond formation of intermediate 246, which on further reaction undergoes Michael-type addition with another molecule of 3-methyl-1-phenyl-1 H -pyrazol-5(4 H )-one 247 keto–enol tautomerism under the influence of the Fe( iii )Y-zeolite solid state catalyst to furnish the desired product 244( Scheme 74 ). 105 …”

Section: Synthesis Of Benzo[ a ]Phenazin-5-olsmentioning

confidence: 99%

“…Initially there occurs condensation between 3 with 2 to give the intermediate benzo[a]phenazin-5-ol 245, the second step is an aldoltype condensation that takes place between aromatic aldehyde with 245, resulting in situ C]C bond formation of intermediate 246, which on further reaction undergoes Michael-type addition with another molecule of 3-methyl-1-phenyl-1H-pyrazol-5(4H)one 247 keto-enol tautomerism under the inuence of the Fe(III) Y-zeolite solid state catalyst to furnish the desired product 244(Scheme 74). 105 In 2018, for the synthesis of pyrazolo-fused benzophenazines 248 in 78-87% yields, Mohebat and co-workers developed a multi-component condensation reaction involving 3, 2a, aromatic aldehydes, and 4-methylbenzenesulfonohydrazide in the presence of phosphotungstic acid (H 3 PW 12 O 40 ) under microwave irradiation (180 W, max. 70 C) in EtOH within 15-20 min.…”

Section: Synthesis Of Benzooxazinophenazinesmentioning

confidence: 99%

A review on lawsone-based benzo[a]phenazin-5-ol: synthetic approaches and reactions

Olyaei

Sadeghpour

2022

RSC Adv.

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“…It results in the fabrication of nanofibers as nanostructured scaffolds mimicking microporosity, intricate morphology of extracellular matrix (ECM), and the possession of beneficial characteristics for tissue healing, tissue growth, disease theranostics, etc. [ 32 , 33 , 34 , 35 , 36 , 37 ]. Numerous scaffolds made of synthetic/natural polymers and their hybrids have been developed for these applications.…”

Section: Introductionmentioning

confidence: 99%

Advances in Electrospun Hybrid Nanofibers for Biomedical Applications

et al. 2022

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Electrospun hybrid nanofibers, based on functional agents immobilized in polymeric matrix, possess a unique combination of collective properties. These are beneficial for a wide range of applications, which include theranostics, filtration, catalysis, and tissue engineering, among others. The combination of functional agents in a nanofiber matrix offer accessibility to multifunctional nanocompartments with significantly improved mechanical, electrical, and chemical properties, along with better biocompatibility and biodegradability. This review summarizes recent work performed for the fabrication, characterization, and optimization of different hybrid nanofibers containing varieties of functional agents, such as laser ablated inorganic nanoparticles (NPs), which include, for instance, gold nanoparticles (Au NPs) and titanium nitride nanoparticles (TiNPs), perovskites, drugs, growth factors, and smart, inorganic polymers. Biocompatible and biodegradable polymers such as chitosan, cellulose, and polycaprolactone are very promising macromolecules as a nanofiber matrix for immobilizing such functional agents. The assimilation of such polymeric matrices with functional agents that possess wide varieties of characteristics require a modified approach towards electrospinning techniques such as coelectrospinning and template spinning. Additional focus within this review is devoted to the state of the art for the implementations of these approaches as viable options for the achievement of multifunctional hybrid nanofibers. Finally, recent advances and challenges, in particular, mass fabrication and prospects of hybrid nanofibers for tissue engineering and biomedical applications have been summarized.

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Nanofibrous matrixes with biologically active hydroxybenzophenazine pyrazolone compound for cancer theranostics

Cited by 14 publications

References 49 publications

Modulating the Mechanical Properties of Electrospun PHB/PCL Materials by Using Different Types of Collectors and Heat Sealing

Modulating the Mechanical Properties of Electrospun PHB/PCL Materials by Using Different Types of Collectors and Heat Sealing

A review on lawsone-based benzo[a]phenazin-5-ol: synthetic approaches and reactions

Advances in Electrospun Hybrid Nanofibers for Biomedical Applications

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