Nanoflowers: the future trend of nanotechnology for multi-applications

Shende, Pravin; Kasture, Pooja; Gaud, Ram

doi:10.1080/21691401.2018.1428812

Cited by 158 publications

(87 citation statements)

References 80 publications

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“…Its appearance signals the formation of the chain-like Ag nanostructures [46] seen in figures 6(a)-(c). The black color is attributed to the formation of flower-like structures on NP aggregation and coalescence, which enhance light absorption, reduce light scattering [53]. Clearly, the decrease of SPR peak intensity with heating time indicates that the amount of monodisperse NPs has decreased because of aggregation, the aggregate forming the second peak.…”

Section: Resultsmentioning

confidence: 99%

Destabilization of PVA-stabilized Ag NPs: color changes at low aqueous concentrations, induced by aggregation and coalescence

Yang²,

Zhu

et al. 2020

Mater. Res. Express

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Aqueous concentrations of poly(vinyl alcohol) (PVA)-stabilized ∼10 nm silver nanoparticles (Ag NPs), in the 1000 ppm concentration range, have been shown to be highly stable at elevated temperatures. However, lower concentrations of these NPs undergo color changes, without precipitation, when heated or when held for extended periods of time at room temperature. We have studied their optical and morphological changes at 80°C, using UV-vis spectra and TEM, and found that their color, at a concentration of 10 ppm, changes from yellow to claret-red to black without precipitation. Further, the plasmon resonance peak at ∼400 nm diminishes as a new peak develops at ∼550 nm. These changes occur as the previously well-dispersed NPs (yellow color) agglomerate to chains (claret-red color) and, finally, coalesce (black color). We discuss the cause of the instability.

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Section: Resultsmentioning

confidence: 99%

Destabilization of PVA-stabilized Ag NPs: color changes at low aqueous concentrations, induced by aggregation and coalescence

Yang²,

Zhu

et al. 2020

Mater. Res. Express

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“…In this respect, a wide variety of ZnO nanostructures can be prepared by monitoring the growth rates along those orientations [45][46][47][48]. The resulting nZnO show distinct biomedical activity, cytotoxicity, and application [49][50][51][52][53][54][55][56]. For instance, ZnO quantum dots can be employed as imaging nanoprobes for targeting cancer cells in vitro [51].…”

Section: Lattice Structurementioning

confidence: 99%

“…For instance, ZnO quantum dots can be employed as imaging nanoprobes for targeting cancer cells in vitro [51]. ZnO nanoflowers serve as effective drug delivery vehicles for biomedical applications [55]. nanoprobes for targeting cancer cells in vitro [51].…”

Section: Lattice Structurementioning

confidence: 99%

Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity

Liao

Jin

et al. 2020

IJMS

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This article presents a state-of-the-art review and analysis of literature studies on the morphological structure, fabrication, cytotoxicity, and photocatalytic toxicity of zinc oxide nanostructures (nZnO) of mammalian cells. nZnO with different morphologies, e.g., quantum dots, nanoparticles, nanorods, and nanotetrapods are toxic to a wide variety of mammalian cell lines due to in vitro cell–material interactions. Several mechanisms responsible for in vitro cytotoxicity have been proposed. These include the penetration of nZnO into the cytoplasm, generating reactive oxygen species (ROS) that degrade mitochondrial function, induce endoplasmic reticulum stress, and damage deoxyribonucleic acid (DNA), lipid, and protein molecules. Otherwise, nZnO dissolve extracellularly into zinc ions and the subsequent diffusion of ions into the cytoplasm can create ROS. Furthermore, internalization of nZnO and localization in acidic lysosomes result in their dissolution into zinc ions, producing ROS too in cytoplasm. These ROS-mediated responses induce caspase-dependent apoptosis via the activation of B-cell lymphoma 2 (Bcl2), Bcl2-associated X protein (Bax), CCAAT/enhancer-binding protein homologous protein (chop), and phosphoprotein p53 gene expressions. In vivo studies on a mouse model reveal the adverse impacts of nZnO on internal organs through different administration routes. The administration of ZnO nanoparticles into mice via intraperitoneal instillation and intravenous injection facilitates their accumulation in target organs, such as the liver, spleen, and lung. ZnO is a semiconductor with a large bandgap showing photocatalytic behavior under ultraviolet (UV) light irradiation. As such, photogenerated electron–hole pairs react with adsorbed oxygen and water molecules to produce ROS. So, the ROS-mediated selective killing for human tumor cells is beneficial for cancer treatment in photodynamic therapy. The photoinduced effects of noble metal doped nZnO for creating ROS under UV and visible light for killing cancer cells are also addressed.

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“…To the best of our knowledge, there has been no research on the synthesis of platinum nanoflowers (Pt NFs) with small and uniform size by the radiolytic method. NFs are a special category of nanoscale materials containing a special combination of elements which, when viewed microscopically, look like flowers [32,33]. Nowadays, NFs have attracted intensive attention due to their high resistance, simple preparation processes, increased efficiency, and high stability [34].…”

Section: Introductionmentioning

confidence: 99%

A Facile One-Pot Synthesis of Versatile PEGylated Platinum Nanoflowers and Their Application in Radiation Therapy

Yang

Salado-Leza

Porcel

et al. 2020

IJMS

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Nanomedicine has stepped into the spotlight of radiation therapy over the last two decades. Nanoparticles (NPs), especially metallic NPs, can potentiate radiotherapy by specific accumulation into tumors, thus enhancing the efficacy while alleviating the toxicity of radiotherapy. Water radiolysis is a simple, fast and environmentally-friendly method to prepare highly controllable metallic nanoparticles in large scale. In this study, we used this method to prepare biocompatible PEGylated (with Poly(Ethylene Glycol) diamine) platinum nanoflowers (Pt NFs). These nanoagents provide unique surface chemistry, which allows functionalization with various molecules such as fluorescent markers, drugs or radionuclides. The Pt NFs were produced with a controlled aggregation of small Pt subunits through a combination of grafted polymers and radiation-induced polymer cross-linking. Confocal microscopy and fluorescence lifetime imaging microscopy revealed that Pt NFs were localized in the cytoplasm of cervical cancer cells (HeLa) but not in the nucleus. Clonogenic assays revealed that Pt NFs amplify the gamma rays induced killing of HeLa cells with a sensitizing enhancement ratio (SER) of 23%, thus making them promising candidates for future cancer radiation therapy. Furthermore, the efficiency of Pt NFs to induce nanoscopic biomolecular damage by interacting with gamma rays, was evaluated using plasmids as molecular probe. These findings show that the Pt NFs are efficient nano-radio-enhancers. Finally, these NFs could be used to improve not only the performances of radiation therapy treatments but also drug delivery and/or diagnosis when functionalized with various molecules.

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Nanoflowers: the future trend of nanotechnology for multi-applications

Cited by 158 publications

References 80 publications

Destabilization of PVA-stabilized Ag NPs: color changes at low aqueous concentrations, induced by aggregation and coalescence

Destabilization of PVA-stabilized Ag NPs: color changes at low aqueous concentrations, induced by aggregation and coalescence

Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity

A Facile One-Pot Synthesis of Versatile PEGylated Platinum Nanoflowers and Their Application in Radiation Therapy

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