Nanoformulating Cinnamomum zeylanicum essential oil with an extreme effect on Leishmania tropica and Leishmania major

Ghanbariasad, Ali; Valizadeh, Alireza; Ghadimi, Shamsi Noorpisheh; Fereidouni, Zhila; Osanloo, Mahmoud

doi:10.1016/j.jddst.2021.102436

Cited by 22 publications

(15 citation statements)

References 42 publications

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“…Ingredients of the used EOs in the current study (i.e., Cinnamon and Clove) were identified using Gas Chromatography-Mass Spectrometry and reported in our previous reports. Cinnamaldehyde, with 62.04%, is the major component of Cinnamon EO, and linalool (6.96%), trans -caryophyllene (6.60%), trans -cinnamyl acetate (4.29%), and benzyl benzoate (3.32%) are other major constituents [ 44 ]. Besides, eugenol, with 65.41%, is the major component in Clove EO.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study

Esmaeili

Zahmatkeshan

Yousefpoor

et al. 2022

BMC Complement Med Ther

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Background Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels have been widely used to increase topical drug delivery and effectiveness. Methods This study aimed to explore the anti-inflammatory effect (paw edema test) and the anti-nociceptive effect (hot plate and formalin test) of nanoemulsion-based gels containing the essential oils in the animal model. Cinnamon and Clove essential oils nanoemulsions with droplet sizes of 28 ± 6 nm and 12 ± 3 nm were first prepared. By adding carboxymethylcellulose (3.5% w/v), the nanoemulsions were then gelified. Finally, the nanogels were characterized by ATR-FTIR analysis and were used as topical pre-treatment before induction of inflammation or pain in acute and chronic analgesic experimental studies. Results The paw edema and formalin findings showed that the nanogels formulations possess significant anti-nociceptive and anti-inflammatory effects. Conclusion The prepared nanogels could be considered as analgesic drugs for inhibiting the inflammation and pain of diseases.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study

Esmaeili

Zahmatkeshan

Yousefpoor

et al. 2022

BMC Complement Med Ther

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“…In the study conducted by Ghanbariasad et al. (2021), C. zeylanicum displayed potent antileishmanial activity against L. major and L. tropica with 50% inhibitory concentrations of 16.53 and 7.56 μg/ml, respectively ( Ghanbariasad et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Potential and Safety of the Cinnamomum zeylanicum Methanolic Extract Against Chronic Toxoplasma gondii Infection in Mice

Alanazi

Al-Mohammed

2022

Front. Cell. Infect. Microbiol.

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BackgroundThis experimental study determined the in vitro, in vivo, and toxicity effects of Cinnamomum zeylanicum methanolic extract (CZME) against Toxoplasma gondii infection.MethodsThe in vitro activity of CZME T. gondii tachyzoites was studied by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Infected mice were treated with CZME for two weeks at doses of 20, 40, and 60 mg/kg/day. Then, the therapeutic effects of CZME were evaluated by assessing the mean number and mean size of T. gondii tissue cysts, oxidant-antioxidant enzymes, pro-inflammatory cytokines, and mRNA expression levels of bradyzoite surface antigen 1 (BAG1) by real-time PCR.ResultsCZME significantly (p <0.001) increased the mortality rate of parasites in a dose- and time-dependent response. The mean number of intracellular tachyzoites was significantly reduced after CZME therapy. The treatment of infected mice with CZME resulted in a significant (p <0.001) downregulation of BAG1 and the level of lipid peroxidation (LPO) and nitric oxide (NO) as oxidative stress markers. However, a considerable rise (p <0.05) was found in the levels of antioxidant markers such as glutathione peroxidase (GPx), catalase enzyme (CAT), and superoxide dismutase enzyme activity (SOD). In a dose-dependent response, after treatment of infected mice with CZME, the level of pro-inflammatory cytokines of IFN-γ, IL-1β, and IL-12 was considerably elevated. CZME had no significant cytotoxicity on Vero cells, with a 50% cytotoxic concentration of 169.5 ± 5.66 μg/ml.ConclusionThe findings confirmed the promising therapeutic effects of CZME on chronic toxoplasmosis in mice. Nevertheless, further investigations must confirm these results, elucidate its precise mechanisms, and examine its effectiveness in human volunteers.

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“…The chemical composition of the used C. zeylanicum EO was investigated using gas chromatography-mass Spectrometry and reported in our previous study [ 24 ]. As a result, cinnamaldehyde (62%), linalool (7%), transcaryophyllene (7%), transcinnamyl acetate (4%), and benzyl benzoate (3%) were identified as five major compounds [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

A Nanoliposomal Gel Containing Cinnamomum zeylanicum Essential Oil with Effective Repellent against the Main Malaria Vector Anopheles stephensi

Osanloo

Firoozian

Zarenezhad

et al. 2022

Interdisciplinary Perspectives on Infectious Diseases

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Malaria is the most important vector-borne disease; however, mosquito repellents are still a practical approach for controlling malaria, especially in endemic regions. Due to the side effects of synthetic repellents such as N, N-diethyl-meta-toluamide (DEET), the development of natural repellents has received much attention. In this study, nanoliposomes containing 0.5 and 2.5% w/v Cinnamomum zeylanicum essential oil were firstly prepared with particle sizes of 119 ± 6 and 195 ± 9 nm. Their morphologies and loading of the essential oil in the particles were then investigated using transmission electron microscopy (TEM) and attenuated total reflection-Fourier transform infrared (ATR-FTIR) analyses. The nanoliposomes were finally jellified to increase their viscosity and facilitate topical usage. The complete protection time of the nanoliposomal gel containing 2.5% C. zeylanicum essential oil was significantly longer than that of 2.5% DEET against Anopheles stephensi: 303 ± 10 > 242 ± 12 min, p < 0.001 . Moreover, the prepared nanoformulation was stable for at least six months at 4 and 26°C. Therefore, the prepared prototype could be considered a natural repellent against the main malaria mosquito vector in field conditions. In addition, it is suggested to be investigated against other important factors mosquitoes.

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Nanoformulating Cinnamomum zeylanicum essential oil with an extreme effect on Leishmania tropica and Leishmania major

Cited by 22 publications

References 42 publications

Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study

Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study

Therapeutic Potential and Safety of the Cinnamomum zeylanicum Methanolic Extract Against Chronic Toxoplasma gondii Infection in Mice

A Nanoliposomal Gel Containing Cinnamomum zeylanicum Essential Oil with Effective Repellent against the Main Malaria Vector Anopheles stephensi

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