Nanogated Mesoporous Silica Materials

Slowing, Igor I.; Trewyn, Brian G.; Lin, Victor S.‐Y.

doi:10.1002/9780470552704.ch16

Cited by 3 publications

(1 citation statement)

References 89 publications

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“…While endosomal escape represents a daunting challenge in the field, many studies have suggested potential solutions for effective release of nanoparticles inside cells. 71,72 Much progress has been made in subcellular targeting of nanoparticles within the context of drug delivery, 73 as well as medical applications-especially for oncology (e.g., thermal ablation of tumor cells). 74 Efforts include surface modifications, bioconjugate reactions, 75 and hybridization of different nanocomponents including, but not limited to, liposomes, micelles, mesoporous silica, polymers, viruses, AuNPs, and carbon nanotubes.…”

Section: Outlook For Future Intracellular Modulationmentioning

confidence: 99%

Learning from Solar Energy Conversion: Biointerfaces for Artificial Photosynthesis and Biological Modulation

Lee

Tian

2019

Nano Lett.

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Three seemingly distinct directions of nanomaterials research, photovoltaics, biofuel production, and biological modulation, have been sequentially developed over the past several decades. In this Mini Review, we discuss how the insights gleaned from nanomaterials-based solar energy conversion can be adapted to biointerface designs. Because of their size-and shape-dependent optical properties and excellent synthetic control, nanomaterials have shown unique technological advantages as the light absorbers or energy transducers. Biocompatible nanomaterials have also been incorporated into biological systems including biomolecules, bacteria, and eukaryotic cells for a large collection of fundamental studies and applications. For the photocatalytic biofuel production, either isolated bacterial enzymes or the entire bacteria have been hybridized with the nanomaterials, where functions from both parts are synergistically integrated. Likewise, interfacing nanomaterials with eukaryotic systems, whether in individual cells or tissues, has enabled optical modulation of cellular behavior and the construction of active cellular materials.Here we survey different approaches in which nanomaterials are used to elicit electrical or mechanical changes in single cells or cellular assemblies via photoelectrochemical or photothermal processes. We end this Mini Review with the discussion of future nongenetic modulation at the intracellular level.

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Section: Outlook For Future Intracellular Modulationmentioning

confidence: 99%

Learning from Solar Energy Conversion: Biointerfaces for Artificial Photosynthesis and Biological Modulation

Lee

Tian

2019

Nano Lett.

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Thermosensitive Cation‐Selective Mesochannels: PNIPAM‐Capped Mesoporous Thin Films as Bioinspired Interfacial Architectures with Concerted Functions

Schmidt

Alberti

Vana

et al. 2017

Chemistry A European J

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Rational design and elaborate modular construction of interfacial architectures in which molecular transport is mediated by responsive/adaptive nanostructures has become a growing and fertile field of research in supramolecular materials chemistry. This work presents, for the first time, the use of PNIPAM-capped mesoporous silica thin films as thermosensitive cation-selective mesochannels. Thus far, this feature has only been observed in thermosensitive biological channels. The interfacial architecture created here accomplishes its specific functions through the concerted or simultaneous action of spatially addressed subunits with temperature response and ion exclusion capabilities. The thermo-perm-selectivity effect stems from the synergistic interplay between the pH-dependent electrostatic characteristics of the silica scaffold and the thermo-controlled steric effects introduced by the capping brush layer. It is hoped that the "nanoarchitectonic" approach presented here will provide new routes toward the generation of heterosupramolecular nanosystems displaying addressable transport properties similar to those encountered in biological ion channels.

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Luminescence Amplification Strategies Integrated with Microparticle and Nanoparticle Platforms

Zhu

Fischer

Wan

et al. 2010

Luminescence Applied in Sensor Science

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The amplification of luminescence signals is often the key to sensitive and powerful detection protocols. Besides optimized fluorescent probes and labels, functionalized nano- and microparticles have received strongly increasing attention in this context during the past decade. This contribution introduces the main signalling concepts for particle-based amplification strategies and stresses, especially the important role that metal and semiconductor nanoparticles play in this field. Besides resonance energy transfer, metal-enhanced emission and the catalytic generation of luminescence, the impact of multi-chromophoric objects such as dye nanocrystals, dendrimers, conjugated polymers or mesoporous hybrid materials is assessed. The representative examples discussed cover a broad range of analytes from metal ions and small organic molecules to oligonucleotides and enzyme activity.

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Nanogated Mesoporous Silica Materials

Cited by 3 publications

References 89 publications

Learning from Solar Energy Conversion: Biointerfaces for Artificial Photosynthesis and Biological Modulation

Learning from Solar Energy Conversion: Biointerfaces for Artificial Photosynthesis and Biological Modulation

Thermosensitive Cation‐Selective Mesochannels: PNIPAM‐Capped Mesoporous Thin Films as Bioinspired Interfacial Architectures with Concerted Functions

Luminescence Amplification Strategies Integrated with Microparticle and Nanoparticle Platforms

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