Nanogels co-loading paclitaxel and curcumin prepared <i>in situ</i> through photopolymerization at 532 nm for synergistically suppressing breast tumors

Song, Xiaoyan; Feng, Zujian; Peng, Yuanyuan; Yu, Siyuan; Du, Xinjing; Huang, Pingsheng; Xing, Jinfeng

doi:10.1039/d2tb02254k

Cited by 5 publications

References 43 publications

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Microwave‐Assisted Synthesis of Porous Biomolecule‐Incorporated Metal‐Organic Frameworks as Efficient Nanocarriers for Anti‐Cancer Drugs

Nguyen

et al. 2023

ChemistrySelect

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Biomolecule‐incorporated metal‐organic frameworks (b‐MOFs) exhibit enhanced bioavailability and biocompatibility, making them an ideal option for use as drug delivery vehicles. While b‐MOFs possess outstanding drug loading and release capabilities, their microscale crystal sizes restrict their applicability as nanocarriers and drug delivery systems. To overcome this limitation, this paper presents a microwave‐irradiation‐based technique for the synthesis of porous adenine‐incorporated Zn‐based MOFs with particle sizes of approximately 200 nm as paclitaxel nanocarriers. The nanomaterial demonstrated a substantial paclitaxel loading capacity of 637 mg g−1. Moreover, it effectively increased the solubility of paclitaxel by 2.5‐fold compared to that of the free form. Thus, the nano MOF is a promising delivery vehicle for paclitaxel. Notably, the paclitaxel‐loaded nano MOF exhibited higher toxicity toward cancer cells than the free drug, further highlighting its potential as an effective anticancer agent.

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Microwave‐Assisted Synthesis of Porous Biomolecule‐Incorporated Metal‐Organic Frameworks as Efficient Nanocarriers for Anti‐Cancer Drugs

Nguyen

et al. 2023

ChemistrySelect

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Curcumin and nanodelivery systems: New directions for targeted therapy and diagnosis of breast cancer

Zhou,

Gong,

Deng

et al. 2024

Biomedicine & Pharmacotherapy

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Adjustment in physicochemical properties of PMMA particles through different photopolymerization methods to achieve their functional applications in various scenarios

Yu,

Peng,

Wang

et al. 2025

Reactive and Functional Polymers

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Nanogels co-loading paclitaxel and curcumin prepared in situ through photopolymerization at 532 nm for synergistically suppressing breast tumors

Abstract: Combined chemotherapy plays an increasingly important and practical role in the clinical treatment of malignant tumor. In this study, paclitaxel (PTX) and curcumin (Cur) are simultaneously encapsulated into nanogels (termed...

Cited by 5 publications

References 43 publications

Microwave‐Assisted Synthesis of Porous Biomolecule‐Incorporated Metal‐Organic Frameworks as Efficient Nanocarriers for Anti‐Cancer Drugs

Microwave‐Assisted Synthesis of Porous Biomolecule‐Incorporated Metal‐Organic Frameworks as Efficient Nanocarriers for Anti‐Cancer Drugs

Curcumin and nanodelivery systems: New directions for targeted therapy and diagnosis of breast cancer

Adjustment in physicochemical properties of PMMA particles through different photopolymerization methods to achieve their functional applications in various scenarios

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