Nanogels for Tissue Engineering

Thompson, Jefferson C; Dua, Rupak

doi:10.1039/9781788010481-00077

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Amine glycoproteins were commonly used for the synthesis of nanogels due to the higher reactivity of activated esters, carboxylic acids, isocyanates, etc., ( Thompson and Dua, 2017 ). The reaction between pentafluorophenyl (PFP) activated esters, which are hydrophobic, and diamine (cross-linker) produces hydrophilic nanogels.…”

Section: Nanogel Classificationmentioning

confidence: 99%

Nanogels as novel drug nanocarriers for CNS drug delivery

Manimaran

Nivetha

Tamilanban

et al. 2023

Front. Mol. Biosci.

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Nanogels are highly recognized as adaptable drug delivery systems that significantly contribute to improving various therapies and diagnostic examinations for different human diseases. These three-dimensional, hydrophilic cross-linked polymers have the ability to absorb large amounts of water or biological fluids. Due to the growing demand for enhancing current therapies, nanogels have emerged as the next-generation drug delivery system. They effectively address the limitations of conventional drug therapy, such as poor stability, large particle size, and low drug loading efficiency. Nanogels find extensive use in the controlled delivery of therapeutic agents, reducing adverse drug effects and enabling lower therapeutic doses while maintaining enhanced efficacy and patient compliance. They are considered an innovative drug delivery system that highlights the shortcomings of traditional methods. This article covers several topics, including the involvement of nanogels in the nanomedicine sector, their advantages and limitations, ideal properties like biocompatibility, biodegradability, drug loading capacity, particle size, permeability, non-immunological response, and colloidal stability. Additionally, it provides information on nanogel classification, synthesis, drug release mechanisms, and various biological applications. The article also discusses barriers associated with brain targeting and the progress of nanogels as nanocarriers for delivering therapeutic agents to the central nervous system.

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Section: Nanogel Classificationmentioning

confidence: 99%

Nanogels as novel drug nanocarriers for CNS drug delivery

Manimaran

Nivetha

Tamilanban

et al. 2023

Front. Mol. Biosci.

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“…Li et al demonstrated biodegradable nanogels as an intracellular therapeutic delivery platform [44]. These materials are of great interest in nanomedicine because of their applicability for tissue engineering [45], cancer therapies [46], scaffold applications [47], imaging [48], theranostics [49], gene delivery [50], and pH-responsive behaviors [51].…”

Section: Nanogels As Potential Drug Nanocarriersmentioning

confidence: 99%

Nanogels as potential drug nanocarriers for CNS drug delivery

Vashist

Kaushik

Vashist

et al. 2018

Drug Discovery Today

116

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Hydrogel-based drug delivery systems (DDSs) have versatile applications such, as tissue engineering, scaffolds, drug delivery, and regenerative medicines. The drawback of higher size and poor stability in such DDSs are being addressed by developing nano-sized hydrogel particles, known as nanogels, to achieve the desired biocompatibility and encapsulation efficiency for better efficacy than conventional bulk hydrogels. In this review, we describe advances in the development of nanogels and their promotion as nanocarriers to deliver therapeutic agents to the central nervous system (CNS). We also discuss the challenges, possible solutions, and future prospects for the use of nanogel-based DDSs for CNS therapies.

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Smart Nanogels for Biomedical Applications

Vashist

Kaushik

Chinnapaiyan

et al. 2020

Fundamentals of Smart Materials

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Chapter 22 Smart nanogels are one of the most important innovations that have emerged in the field of nanomedicine and biomedical applications. In recent advances in the applications of biomaterials, nanogels have emerged as novel candidates for drug delivery, biosensing, imaging, tissue engineering, and targeted delivery of bioactive compounds. The present chapter gives a basic understanding of the hydrogels and introduces the nanoparticle form of hydrogels known as “Nanogels.” Nanogels have synergistic properties due to their interpenetrating networks as well as nanoscale properties such as small size and high surface-to-volume ratio. These hybrid materials exhibit high drug loading, are capable of crossing strong barriers and are also highly biocompatible. In brief, this chapter describes the basic synthetic methodology and characterization techniques of nanogels. It also discusses the natural and synthetic polymers deployed for the synthesis of nanogels. Moreover, it highlights the important literature reported for the biomedical applications of nanogels.

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Nanogels for Tissue Engineering

Cited by 3 publications

References 37 publications

Nanogels as novel drug nanocarriers for CNS drug delivery

Nanogels as novel drug nanocarriers for CNS drug delivery

Nanogels as potential drug nanocarriers for CNS drug delivery

Smart Nanogels for Biomedical Applications

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