Nanohydroxyapatite incorporated photocrosslinked gelatin methacryloyl/poly(ethylene glycol)diacrylate hydrogel for bone tissue engineering

Sreekumaran, Sreekanth; Radhakrishnan, Anitha; Rauf, Arun A.; Kurup, G. Muraleedhara

doi:10.1007/s40204-021-00150-x

Cited by 35 publications

(27 citation statements)

References 42 publications

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“…In addition, it belongs to the large flat peak O-H stress vibrations observed at 3260 cm À1 in the FTIR spectra of gelatin and GelMA. 39 All the results showed that the methacrylation reaction took place and the GelMA polymer was successfully synthesized.…”

Section: Characterization Of Gelatin and Gelmamentioning

confidence: 96%

Photocurable silk fibroin-based tissue sealants with enhanced adhesive properties for the treatment of corneal perforations

et al. 2022

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Section: Characterization Of Gelatin and Gelmamentioning

confidence: 96%

Photocurable silk fibroin-based tissue sealants with enhanced adhesive properties for the treatment of corneal perforations

et al. 2022

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“…Moreover, smaller pore size and penetrated channel facilitate signal transduction between cells (Murphy et al, 2010;Perez and Mestres, 2016). In this study, the ideal multi-network pore structure, morphology, size, and varied orientation of the hydrogel scaffold were acquired and superior to the results of previous studies (Xu et al, 2020;Sreekumaran et al, 2021). Meanwhile, the cell-scaffold and cell-cell interaction are affected by the microstructure, surface roughness, and structural stability of the hydrogel (Schaap-Oziemlak et al, 2014;Xia et al, 2020).…”

Section: Discussionmentioning

confidence: 74%

“…Hydrogels have been widely applied to facilitate functional and constructive tissue repair in many clinical applications. Invaluable qualities such as interconnected porous morphology and architecture similar to extracellular matrix (ECM), irreplaceable water retention capacity, drugs and growth factors delivery effect, and biodegradability enable hydrogel to adapt to specific physical and soft tissue regeneration environment ( Han et al, 2021 ; Sreekumaran et al, 2021 ; Sun et al, 2022 ). Furthermore, some attention has been fortunately drawn to the roles of the non-steroidal anti-inflammatory drug (NSAIDs) of aspirin, since it is used to alleviate the inflammation and activate osteoblasts in the surgical site within the concentration range of 50–300 μg/mL ( Fattahi et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Osteogenic and anti-inflammatory effect of the multifunctional bionic hydrogel scaffold loaded with aspirin and nano-hydroxyapatite

Xiaowen

Yang

et al. 2023

Front. Bioeng. Biotechnol.

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Although tissue engineering offered new approaches to repair bone defects, it remains a great challenge to create a bone-friendly microenvironment and rebuild bone tissue rapidly by a scaffold with a bionic structure. In this study, a multifunctional structurally optimized hydrogel scaffold was designed by integrating polyvinyl alcohol (PVA), gelatin (Gel), and sodium alginate (SA) with aspirin (ASA) and nano-hydroxyapatite (nHAP). The fabrication procedure is through a dual-crosslinking process. The chemical constitution, crystal structure, microstructure, porosity, mechanical strength, swelling and degradation property, and drug-release behavior of the hydrogel scaffold were analyzed. Multi-hydrogen bonds, electrostatic interactions, and strong “egg-shell” structure contributed to the multi-network microstructure, bone tissue-matched properties, and desirable drug-release function of the hydrogel scaffold. The excellent performance in improving cell viability, promoting cell osteogenic differentiation, and regulating the inflammatory microenvironment of the prepared hydrogel scaffold was verified using mouse pre-osteoblasts (MC3T3-E1) cells. And the synergistic osteogenic and anti-inflammatory functions of aspirin and nano-hydroxyapatite were also verified. This study provided valuable insights into the design, fabrication, and biological potential of multifunctional bone tissue engineering materials with the premise of constructing a bone-friendly microenvironment.

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“…Tissue engineering aims to obtain bone grafts with regeneration potential both in vitro and in vivo. These types of materials are usually bioactive and have the ability to repair bones through guided tissue regeneration [4][5][6][7]. Some of the most common biomaterials used for such applications are calcium phosphates, especially hydroxyapatite.…”

Section: Introductionmentioning

confidence: 99%

3D Printable Composite Biomaterials Based on GelMA and Hydroxyapatite Powders Doped with Cerium Ions for Bone Tissue Regeneration

Alexa

Cucuruz

Ghiţulică

et al. 2022

IJMS

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The main objective was to produce 3D printable hydrogels based on GelMA and hydroxyapatite doped with cerium ions with potential application in bone regeneration. The first part of the study regards the substitution of Ca2+ ions from hydroxyapatite structure with cerium ions (Ca10-xCex(PO4)6(OH)2, xCe = 0.1, 0.3, 0.5). The second part followed the selection of the optimal concentration of HAp doped, which will ensure GelMA-based scaffolds with good biocompatibility, viability and cell proliferation. The third part aimed to select the optimal concentrations of GelMA for the 3D printing process (20%, 30% and 35%). In vitro biological assessment presented the highest level of cell viability and proliferation potency of GelMA-HC5 composites, along with a low cytotoxic potential, highlighting the beneficial effects of cerium on cell growth, also supported by Live/Dead results. According to the 3D printing experiments, the 30% GelMA enriched with HC5 was able to generate 3D scaffolds with high structural integrity and homogeneity, showing the highest suitability for the 3D printing process. The osteogenic differentiation experiments confirmed the ability of 30% GelMA-3% HC5 scaffold to support and efficiently maintain the osteogenesis process. Based on the results, 30% GelMA-3% HC5 3D printed scaffolds could be considered as biomaterials with suitable characteristics for application in bone tissue engineering.

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Nanohydroxyapatite incorporated photocrosslinked gelatin methacryloyl/poly(ethylene glycol)diacrylate hydrogel for bone tissue engineering

Cited by 35 publications

References 42 publications

Photocurable silk fibroin-based tissue sealants with enhanced adhesive properties for the treatment of corneal perforations

Photocurable silk fibroin-based tissue sealants with enhanced adhesive properties for the treatment of corneal perforations

Osteogenic and anti-inflammatory effect of the multifunctional bionic hydrogel scaffold loaded with aspirin and nano-hydroxyapatite

3D Printable Composite Biomaterials Based on GelMA and Hydroxyapatite Powders Doped with Cerium Ions for Bone Tissue Regeneration

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