Nanoliquid Dressing with Enhancing Anti-Infection Performance under the Moderate Photothermal Effect for Wound Treatment

Abstract

Nonhealing wounds have become a major healthcare burden worldwide. Chronic wound healing is universally hampered by the presence of bacterial infections that form biofilms. Therefore, in this study, a novel nanoliquid dressing based on a mild photothermal heating strategy was designed to provide safe healing of biofilm-infected wounds. Dilute nitric acid (HNO 3 ) solution was employed to induce a redox process triggered by copper sulfide (CuS) nanoplates in the nanoliquid dressing. This redox process was further promoted by the mild photothermal effect (≤47.5 °C) that generated a sufficient amount of reactive oxygen species, resulting in less thermal injury to normal tissues. Correspondingly, with the safe concentration of CuS nanoplates (0.4 mg/mL), excellent bactericidal efficiencies up to 98.3 and 99.3% against ampicillin-resistant Escherichia coli (Amp r E. coli) and Staphylococcus aureus (S. aureus) were achieved, respectively. Moreover, the nanoliquid dressing exhibited a near-infrared enhanced destructive effect on mature biofilms. According to in vivo wound healing experiments in mice, the nanoliquid dressing increased the healing rate and reduced the inflammatory response. This study provides a novel insight into treating the biofilm-infected chronic wounds in the "post-antibiotic era".

ZnL2-BPs Integrated Bone Scaffold under Sequential Photothermal Mediation: A Win–Win Strategy Delivering Antibacterial Therapy and Fostering Osteogenesis Thereafter

“…In contrast, although the biofilms with green fluorescence are dominant in the BPs@HAP and ZnL 2 -BPs@HAP groups, some dead bacteria with red fluorescence can be detected from the BPs@HAP+Light group and nearly all the bacteria in the ZnL 2 -BPs@HAP+Light group are sterilized and stained red. According to the results obtained by plate counting (Figure S18), the ZnL 2 -BPs@HAP+Light group eliminates 91.34 ± 1.25% of S. aureus and 94.25 ± 1.41% of E. coli in the biofilms, which are significantly higher than those of the other groups and comparable to the other recent studies. , Evidently, the ZnL 2 -BPs@HAP scaffold has outstanding antibacterial and antibiofilm properties upon moderate photothermal radiation.…”

“…34 ± 1.41% of E. coli in the biofilms, which are significantly higher than those of the other groups and comparable to the other recent studies. 28,58 Evidently, the ZnL 2 -BPs@HAP scaffold has outstanding antibacterial and antibiofilm properties upon moderate photothermal radiation. Antibacterial Mechanism.…”

Photo-Sono Interfacial Engineering Exciting the Intrinsic Property of Herbal Nanomedicine for Rapid Broad-Spectrum Bacteria Killing

“…The CuS demonstrated excellent plasmonic absorption due to the localized surface plasmon resonance (LSPR) . Under irradiation with 808 nm light, CuS not only had a good photothermal conversion effect but also could promote ROS production through photocatalytic reaction . When combined with Cur, the CuS/Cur would likely have satisfactory photothermal performance.…”

“…22 Under irradiation with 808 nm light, CuS not only had a good photothermal conversion effect but also could promote ROS production through photocatalytic reaction. 23 When combined with Cur, the CuS/Cur would likely have satisfactory photothermal performance. Thus, photothermal performance of CuS/Cur was measured.…”

Optimization of Nanostructured Copper Sulfide to Achieve Enhanced Enzyme-Mimic Activities for Improving Anti-Infection Performance

“…19 Besides, we found that nano copper sulfides could accelerate the healing of infected mice wounds through the redox reaction with dilute nitric acid. 20 Based on such research, it is highly anticipated that antibacterial performance could be improved through regulating the enzyme-mimic activities of Cu 2-x S nanostructures to promote redox processes. However, currently, indistinct catalytic mechanisms make it extremely difficult to further evaluate the antibacterial performance of Cu 2-x S nanozymes at the atomic level.…”