Nanomaterial-based activatable imaging probes: from design to biological applications

Li, Jingjing; Cheng, Fang; Huang, Haiping; Li, Lingling; Zhu, Jun‐Jie

doi:10.1039/c4cs00476k

Cited by 147 publications

(78 citation statements)

References 194 publications

(327 reference statements)

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“…[138][139][140] PAI can provide multiscale imaging ranging from organelles and individual cells to tissue, organs, and small animals; it has considerable potential for IGS and intraoperative LN mapping. [107,[144][145][146] Gold NPs, with a highest extinction coefficient, [146] have been used extensively for PAI. [143] PAI probes include conventional inorganic and organic NMs, as well as ratiometric and activatable nanoprobes.…”

Section: Paimentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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Surgical resection is the primary and most effective treatment for most patients with solid tumors. However, patients suffer from postoperative recurrence and metastasis. In the past years, emerging nanotechnology has led the way to minimally invasive, precision and intelligent oncological surgery after the rapid development of minimally invasive surgical technology. Advanced nanotechnology in the construction of nanomaterials (NMs) for precision imaging-guided surgery (IGS) as well as surgery-assisted synergistic therapy is summarized, thereby unlocking the advantages of nanotechnology in multimodal IGS-assisted precision synergistic cancer therapy. First, mechanisms and principles of NMs to surgical targets are briefly introduced. Multimodal imaging based on molecular imaging technologies provides a practical method to achieve intraoperative visualization with high resolution and deep tissue penetration. Moreover, multifunctional NMs synergize surgery with adjuvant therapy (e.g., chemotherapy, immunotherapy, phototherapy) to eliminate residual lesions. Finally, key issues in the development of ideal theranostic NMs associated with surgical applications and challenges of clinical transformation are discussed to push forward further development of NMs for multimodal IGS-assisted precision synergistic cancer therapy.

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Section: Paimentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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“…Owing to their highly electron-delocalized structures and efficient coupling between optoelectronic segments, CPs have a particular capability to absorb and emit light energy, which can be effectively converted to fluorescence, heat, and other energies 1,2,3,4 . Conjugated polymer nanomaterials 5,6,7,8,9,10,11 (CPNs), as both optically and electronically active materials, have been shown to be promising theranostic agents 12,13,14,15,16,17,18 . Owing to their excellent light-harvesting and light-amplifying properties, CPNs have been applied to both in vitro and in vivo fluorescence imaging to achieve real-time diagnostics 19,20,21,22,23,24 .…”

Section: Introductionmentioning

confidence: 99%

Conjugated polymer nanomaterials for theranostics

et al. 2017

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Conjugated polymer nanomaterials (CPNs), as optically and electronically active materials, hold promise for biomedical imaging and drug delivery applications. This review highlights the recent advances in the utilization of CPNs in theranostics. Specifically, CPN-based in vivo imaging techniques, including near-infrared (NIR) imaging, two-photon (TP) imaging, photoacoustic (PA) imaging, and multimodal (MM) imaging, are introduced. Then, CPN-based photodynamic therapy (PDT) and photothermal therapy (PTT) are surveyed. A variety of stimuli-responsive CPN systems for drug delivery are also summarized, and the promising trends and translational challenges are discussed.

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“…There is now a strong demand for efficient 2PA dyes for a wide range of applications, including microscopy [4,5,6,7,8,9,10,11,12,13], micro-fabrication [14,15,16], three-dimensional data-storage [17,18], up-converted lasing [19,20], and photodynamic therapy [21,22,23]. Recently, this demand has been matched by rapid advances in the design and synthesis of 2PA dyes [24,25,26,27,28,29,30,31,32,33,34].…”

Section: Introductionmentioning

confidence: 99%

Lighting the Way to See Inside Two-Photon Absorption Materials: Structure–Property Relationship and Biological Imaging

et al. 2017

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The application of two-photon absorption (2PA) materials is a classical research field and has recently attracted increasing interest. It has generated a demand for new dyes with high 2PA cross-sections. In this short review, we briefly cover the structure-2PA property relationships of organic fluorophores, organic-inorganic nanohybrids and metal complexes explored by our group. (1) The two-photon absorption cross-section (δ) of organic fluorophores increases with the extent of charge transfer, which is important to optimize the core, donor-acceptor pair, and conjugation-bridge to obtain a large δ value. Among the various cores, triphenylamine appears to be an efficient core. Lengthening of the conjugation with styryl groups in the D-π-D quadrupoles and D-π-A dipoles increased δ over a long wavelength range than when vinylene groups were used. Large values of δ were observed for extended conjugation length and moderate donor-acceptors in the near-IR wavelengths. The δ value of the three-arm octupole is larger than that of the individual arm, if the core has electron accepting groups that allow significant electronic coupling between the arms; (2) Optical functional organic/inorganic hybrid materials usually show high thermal stability and excellent optical activity; therefore the design of functional organic molecules to build functional organic-inorganic hybrids and optimize the 2PA properties are significant. Advances have been made in the design of organic-inorganic nanohybrid materials of different sizes and shapes for 2PA property, which provide useful examples to illustrate the new features of the 2PA response in comparison to the more thoroughly investigated donor-acceptor based organic compounds and inorganic components; (3) Metal complexes are of particular interest for the design of new materials with large 2PA ability. They offer a wide range of metals with different ligands, which can give rise to tunable electronic and 2PA properties. The metal ions, including transition metals and lanthanides, can serve as an important part of the structure to control the intramolecular charge-transfer process that drives the 2PA process. As templates, transition metal ions can assemble simple to more sophisticated ligands in a variety of multipolar arrangements resulting in interesting and tailorable electronic and optical properties, depending on the nature of the metal center and the energetics of the metal-ligand interactions, such as intraligand charge-transfer (ILCT) and metal-ligand charge-transfer (MLCT) processes. Lanthanide complexes are attractive for a number of reasons: (i) their visible emissions are quite long-lived; (ii) their absorption and emission can be tuned with the aid of appropriate photoactive ligands; (iii) the accessible energy-transfer path between the photo-active ligands and the lanthanide ion can facilitate efficient lanthanide-based 2PA properties. Thus, the above materials with excellent 2PA properties should be applied in two-photon applications, especially two-photon fluorescence m...

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Nanomaterial-based activatable imaging probes: from design to biological applications

Cited by 147 publications

References 194 publications

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Conjugated polymer nanomaterials for theranostics

Lighting the Way to See Inside Two-Photon Absorption Materials: Structure–Property Relationship and Biological Imaging

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