2017
DOI: 10.1080/21691401.2017.1375937
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Nanomaterials as nanocarriers: a critical assessment why these are multi-chore vanquisher in breast cancer treatment

Abstract: Breast cancer is a group of diseases with various subtypes and leads to high mortality throughout the globe. Various conventional techniques are in practice to cure breast cancer but these techniques are linked with various shortcomings. Mostly these treatments are not site directed and cause toxicity towards normal cells. In order to overcome these issues, we need smart system that can deliver anticancer drugs to specific sites. Targeted drug delivery can be achieved via passive or active drug delivery using … Show more

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Cited by 21 publications
(13 citation statements)
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References 231 publications
(224 reference statements)
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“…Ideally, nanocarrier-based antitumor strategies should display stronger toxicity against cancer cells while preserving the integrity of healthy tissues (Naz et al, 2017;Xiao et al, 2017). Even when targeting is possible, healthy areas in the administration site should be safeguarded, especially in the case of small lesions that do not largely compromise the tissue architecture such as atypical and pre-tumor breast lesions and low grade DCIS (Benson et al, 2016;Akram et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Ideally, nanocarrier-based antitumor strategies should display stronger toxicity against cancer cells while preserving the integrity of healthy tissues (Naz et al, 2017;Xiao et al, 2017). Even when targeting is possible, healthy areas in the administration site should be safeguarded, especially in the case of small lesions that do not largely compromise the tissue architecture such as atypical and pre-tumor breast lesions and low grade DCIS (Benson et al, 2016;Akram et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Cancer is nowadays the foremost cause of mortality among threats to mankind, which calls for immediate action and planning. As one of the most widespread types of cancer in female is breast cancer, it is presently cured with various therapies including surgery, radiotherapy, chemotherapy and hormone treatment [1]. A major tumour therapy is radiotherapy that applies ionizing radiation to eradicate cancerous cells [2].…”
Section: Introductionmentioning
confidence: 99%
“…AgNPs show potential cytotoxicity in breast cancer cells MCF‐7 via preventing cell growth by activating production of reactive oxygen species and caspases‐3 which lead to cell death through concentration‐dependent activation of lactate dehydrogenase; by disturbing membrane structure, activating different genes involved in apoptosis leads to cell death [70]. In both antioxidant and cytotoxicity assay results, values are the mean of three replicates and they are statistically significant ( P ˂0.05).…”
Section: Morphological Studiesmentioning
confidence: 99%