Nanomaterials based electrochemical nucleic acid biosensors for environmental monitoring: A review

Hashem, Abu; Hossain, M. A. Motalib; Marlinda, Ab Rahman; Mamun, Mohammad Al; Simarani, Khanom; Johan, Mohd Rafie

doi:10.1016/j.apsadv.2021.100064

Cited by 80 publications

(31 citation statements)

References 135 publications

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“…An efficient, reproducible, and well-controlled self-assembled monolayer of the peptide was formed at the SPAuE surface, followed by treatment with MCH characterized by CV and EIS. Incubation with MCH allowed to block nonspecific binding sites on the SPAuE surface and better orient the synthetic peptide perpendicular to the surface to point to the RBD region of the Spike protein [ [52] , [53] , [54] ].…”

Section: Resultsmentioning

confidence: 99%

Peptide-based simple detection of SARS-CoV-2 with electrochemical readout

Soto

Orozco

2022

Analytica Chimica Acta

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Section: Resultsmentioning

confidence: 99%

Peptide-based simple detection of SARS-CoV-2 with electrochemical readout

Soto

Orozco

2022

Analytica Chimica Acta

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“…6 Even more, nanobiotechnology has continued to improve and the RNA nanoring or globule nanoparticle structures could be used as biosensors and functionalized nanodevices. 30 …”

Section: Discussionmentioning

confidence: 99%

Spontaneous Condensation of RNA into Nanoring and Globular Structures

et al. 2022

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The effect of polyvalent cations, like spermine, on the condensation of DNA into very well-defined toroidal shapes has been well studied and understood. A great effort has been made to obtain similar condensed structures from RNA molecules, but so far, it has been elusive. In this work, we show that single-stranded RNA (ssRNA) molecules can easily be condensed into nanoring and globular structures on a mica surface, where each nanoring structure is formed mostly by a single RNA molecule. The condensation occurs in a concentration range of different cations, from monovalent to trivalent, but at a higher concentration, globular structures appear. RNA nanoring structures were observed on mica surfaces by atomic force microscopy (AFM). The samples were observed in tapping mode and were prepared by drop evaporation of a solution of RNA in the presence of one type of the different cations used. As far as we know, this is the first time that nanorings or any other well-defined condensed RNA structures have been reported in the presence of simple salts. The RNA nanoring formation can be understood by an energy competition between the hydrogen bonding forming hairpin stems—weakened by the salts—and the hairpin loops. This result may have an important biological relevance since it has been proposed that RNA is the oldest genome-coding molecule, and the formation of these structures could have given it stability against degradation in primeval times. Even more, the nanoring structures could have the potential to be used as biosensors and functionalized nanodevices.

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“…Several papers have reported on the uses of NanoTech vis-à-vis BioSS/NanoBioSS for biomedical/clinical/healthcare applications (such as identifying of viruses and pathogen microbes, detecting of cancerous cells, and breath analysis mechanism) [ 27 , 58 ], environmental applications (detection of air, soil, and water pollution) [ 59 – 61 ], and agricultural applications (climate-smart organic agriculture and identification of animals and plants pests and diseases) [ 25 , 48 , 62 – 64 ]. There have also been suggestions on modern materials science vis-à-vis NanoTech been employed in COVID-19-related researches, as this has evidently played a dynamic role in mitigating and combating the present deadly COVID-19 complications via environmental remediation [ 37 ].…”

Section: Nanotech In Bioss/nanobioss Mechanismsmentioning

confidence: 99%

A Methodical Review on the Applications and Potentialities of Using Nanobiosensors for Disease Diagnosis

Ukhurebor

Onyancha

Aigbe

et al. 2022

BioMed Research International

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Presently, with the introduction of nanotechnology, the evolutions and applications of biosensors and/or nanobiosensors are becoming prevalent in various scientific domains such as environmental and agricultural sciences as well as biomedical, clinical, and healthcare sciences. Trends in these aspects have led to the discovery of various biosensors/nanobiosensors with their tremendous benefits to mankind. The characteristics of the various biosensors/nanobiosensors are primarily based on the nature of nanomaterials/nanoparticles employed in the sensing mechanisms. In the last few years, the identification, as well as the detection of biological markers linked with any form of diseases (communicable or noncommunicable), has been accomplished by several sensing procedures using nanotechnology vis-à-vis biosensors/nanobiosensors. Hence, this study employs a systematic approach in reviewing some contemporary developed exceedingly sensitive nanobiosensors alongside their biomedical, clinical, or/and healthcare applications as well as their potentialities, specifically for the detection of some deadly diseases drawn from some of the recent publications. Ways forward in the form of future trends that will advance creative innovations of the potentialities of nanobiosensors for biomedical, clinical, or/and healthcare applications particularly for disease diagnosis are also highlighted.

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Nanomaterials based electrochemical nucleic acid biosensors for environmental monitoring: A review

Cited by 80 publications

References 135 publications

Peptide-based simple detection of SARS-CoV-2 with electrochemical readout

Peptide-based simple detection of SARS-CoV-2 with electrochemical readout

Spontaneous Condensation of RNA into Nanoring and Globular Structures

A Methodical Review on the Applications and Potentialities of Using Nanobiosensors for Disease Diagnosis

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